Home Cart 0 Sign in  

[ CAS No. 1072103-29-7 ]

{[proInfo.proName]} ,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 1072103-29-7
Chemical Structure| 1072103-29-7
Structure of 1072103-29-7 *Storage: {[proInfo.prStorage]}

Quality Control of [ 1072103-29-7 ]

Related Doc. of [ 1072103-29-7 ]

SDS
Alternatived Products of [ 1072103-29-7 ]
Alternatived Products of [ 1072103-29-7 ]

Product Details of [ 1072103-29-7 ]

CAS No. :1072103-29-7MDL No. :MFCD18251373
Formula : C10H12N2O3 Boiling Point : 446.1±45.0°C at 760 mmHg
Linear Structure Formula :-InChI Key :-
M.W :208.21Pubchem ID :58252580
Synonyms :

Computed Properties of [ 1072103-29-7 ]

TPSA : 62.7 H-Bond Acceptor Count : 5
XLogP3 : 0.5 H-Bond Donor Count : 1
SP3 : 0.40 Rotatable Bond Count : 2

Safety of [ 1072103-29-7 ]

Signal Word:WarningClass:N/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1072103-29-7 ]

  • Upstream synthesis route of [ 1072103-29-7 ]
  • Downstream synthetic route of [ 1072103-29-7 ]

[ 1072103-29-7 ] Synthesis Path-Upstream   1~8

  • 1
  • [ 1301214-68-5 ]
  • [ 1072103-29-7 ]
YieldReaction ConditionsOperation in experiment
71%
Stage #1: Reflux
Stage #2: With hydrogenchloride In water
25percent KOH (100 mL) was added to 4-[6-(piperidin-1-ylcarbonyl)pyridin-3-yl]morpholine (18.3 g), and the mixture was refluxed and then neutralized with HCl.
The solution was evaporated in vacuum, and the product was extracted with hot isopropanol to give the title compound (yield 71percent, 11.5 g).
+ESI MS (M+H) 209.7; 1H NMR (400 MHz, DMSO-d6) δ ppm 8.34 (br. s., 1H), 8.03 (d, 1H), 7.65 (dd, 1H), 3.75 (br. s., 4H), 3.40 (br. s., 4H).
71%
Stage #1: Reflux
Stage #2: With hydrogenchloride In water
25percent KOH (100 ml_) was added to 4-[6-(piperidin-1-ylcarbonyl)pyridin-3- yl]morpholine (18.3 g), and the mixture was refluxed and then neutralized with HCI. The solution was evaporated in vacuum, and the product was extracted with hot isopropanol to give the title compound (yield 71 percent, 11.5 g). +ESI MS (M+H) 209.7; 1H NMR (400 MHz, DMSO-c/6) ppm 8.34 (br. s., 1 H), 8.03 (d, 1 H), 7.65 (dd, 1 H), 3.75 (br. s., 4 H), 3.40 (br. s., 4 H).
Reference: [1] Patent: US2011/111046, 2011, A1, . Location in patent: Page/Page column 15
[2] Patent: WO2011/58473, 2011, A1, . Location in patent: Page/Page column 30
  • 2
  • [ 60891-70-5 ]
  • [ 1072103-29-7 ]
Reference: [1] Patent: US2011/111046, 2011, A1,
[2] Patent: WO2011/58473, 2011, A1,
  • 3
  • [ 4548-45-2 ]
  • [ 1072103-29-7 ]
Reference: [1] Patent: US2011/111046, 2011, A1,
[2] Patent: WO2011/58473, 2011, A1,
  • 4
  • [ 29682-14-2 ]
  • [ 1072103-29-7 ]
Reference: [1] Patent: US2011/111046, 2011, A1,
[2] Patent: WO2011/58473, 2011, A1,
  • 5
  • [ 30651-24-2 ]
  • [ 1072103-29-7 ]
Reference: [1] Patent: US2011/111046, 2011, A1,
[2] Patent: WO2011/58473, 2011, A1,
  • 6
  • [ 1301214-66-3 ]
  • [ 1072103-29-7 ]
Reference: [1] Patent: US2011/111046, 2011, A1,
[2] Patent: WO2011/58473, 2011, A1,
  • 7
  • [ 1301214-67-4 ]
  • [ 1072103-29-7 ]
Reference: [1] Patent: US2011/111046, 2011, A1,
[2] Patent: WO2011/58473, 2011, A1,
  • 8
  • [ 1301214-65-2 ]
  • [ 1072103-29-7 ]
Reference: [1] Patent: US2011/111046, 2011, A1,
[2] Patent: WO2011/58473, 2011, A1,
Historical Records

Related Functional Groups of
[ 1072103-29-7 ]

Carboxylic Acids

Chemical Structure| 24242-20-4

[ 24242-20-4 ]

5-Aminopicolinic acid

Similarity: 0.78

Chemical Structure| 848308-47-4

[ 848308-47-4 ]

5-((tert-Butoxycarbonyl)amino)picolinic acid

Similarity: 0.72

Chemical Structure| 30651-24-2

[ 30651-24-2 ]

5-Nitro-2-pyridinecarboxylic acid

Similarity: 0.68

Chemical Structure| 98-98-6

[ 98-98-6 ]

Picolinic acid

Similarity: 0.68

Chemical Structure| 934-60-1

[ 934-60-1 ]

6-Methyl-2-pyridinecarboxylic acid

Similarity: 0.67

Related Parent Nucleus of
[ 1072103-29-7 ]

Morpholines

Chemical Structure| 722549-98-6

[ 722549-98-6 ]

4-Morpholinopyridin-2-amine

Similarity: 0.61

Chemical Structure| 1049023-41-7

[ 1049023-41-7 ]

4-(2-Bromopyridin-4-yl)morpholine

Similarity: 0.61

Chemical Structure| 1215107-26-8

[ 1215107-26-8 ]

(5-Morpholinopyridin-3-yl)boronic acid

Similarity: 0.59

Chemical Structure| 215309-00-5

[ 215309-00-5 ]

3-Morpholinobenzoic acid

Similarity: 0.59

Chemical Structure| 1204-86-0

[ 1204-86-0 ]

4-Morpholinobenzaldehyde

Similarity: 0.57

Pyridines

Chemical Structure| 24242-20-4

[ 24242-20-4 ]

5-Aminopicolinic acid

Similarity: 0.78

Chemical Structure| 67515-76-8

[ 67515-76-8 ]

Methyl 5-aminopicolinate

Similarity: 0.76

Chemical Structure| 850689-13-3

[ 850689-13-3 ]

Methyl 4,5-diaminopicolinate

Similarity: 0.73

Chemical Structure| 848308-47-4

[ 848308-47-4 ]

5-((tert-Butoxycarbonyl)amino)picolinic acid

Similarity: 0.72

Chemical Structure| 773140-43-5

[ 773140-43-5 ]

Ethyl 4-aminopicolinate

Similarity: 0.70