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Chemical Structure| 1076-74-0 Chemical Structure| 1076-74-0

Structure of 5-Methoxy-2-methylindole
CAS No.: 1076-74-0

Chemical Structure| 1076-74-0

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Product Details of [ 1076-74-0 ]

CAS No. :1076-74-0
Formula : C10H11NO
M.W : 161.20
SMILES Code : CC(N1)=CC2=C1C=CC(OC)=C2
MDL No. :MFCD00005620
InChI Key :VSWGLJOQFUMFOQ-UHFFFAOYSA-N
Pubchem ID :70642

Safety of [ 1076-74-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of [ 1076-74-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1076-74-0 ]

[ 1076-74-0 ] Synthesis Path-Downstream   1~3

  • 3
  • [ 23784-96-5 ]
  • [ 1076-74-0 ]
  • [ 1383843-44-4 ]
YieldReaction ConditionsOperation in experiment
8% To a solution of 5-methoxy-2-methyl- 1 H-indole ( 1.50 g, 9.31 mmol) in N,N- dimethylformamide (10 mL) at 0 C was added sodium hydride (0.558 g, 14.0 mmol). The reaction was stirred at room temperature for 20 minutes, after which 2-chloro-5- (chloromethyl)thiophene (1.87 g, 11.2 mmol) was added. The reaction mixture was stirred at 80 C for 24 hours, after which it was diluted with water, extracted with ethyl acetate (3 x 50 mL), washed with water, then washed with saturated sodium bicarbonate solution, dried (magnesium sulfate), filtered and concentrated. Purification was achieved by silica gel chromatography (ISCO 40g) using 0 to 80% ethyl acetate in hexanes to afford 5-methoxy-2- methyl-l-(pyridin-2-ylmethyl)-l H-indole as a yellow-brown solid in 8% yield.
 

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[ 1076-74-0 ]

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