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[ CAS No. 107806-82-6 ] {[proInfo.proName]}

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Chemical Structure| 107806-82-6
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Product Details of [ 107806-82-6 ]

CAS No. :107806-82-6 MDL No. :MFCD20639625
Formula : C9H8O4 Boiling Point : -
Linear Structure Formula :- InChI Key :MBBAIOHGDCOFGT-UHFFFAOYSA-N
M.W : 180.16 Pubchem ID :15764027
Synonyms :

Safety of [ 107806-82-6 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501 UN#:
Hazard Statements:H302-H312-H332 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 107806-82-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 107806-82-6 ]

[ 107806-82-6 ] Synthesis Path-Downstream   1~17

  • 1
  • [ 860588-20-1 ]
  • [ 107806-82-6 ]
  • 2
  • [ 107806-82-6 ]
  • 2-acetoxy-4-acetyl-benzoic acid [ No CAS ]
  • 3
  • [ 107806-82-6 ]
  • [ 151-50-8 ]
  • (R,S)-α-methyl-4-carboxy-3-hydroxyphenylglycine [ No CAS ]
YieldReaction ConditionsOperation in experiment
Stage #1: 4-carboxy-3-hydroxyacetophenone; potassium cyanide With acetamide; ammonium carbonate Stage #2: With hydrogenchloride
  • 4
  • [ 1432-42-4 ]
  • [ 107806-82-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: aqueous sulfuric acid; copper (II)-sulfate; aqueous ammonia 2: iron; aqueous acetic acid 3: aqueous KOH-solution
  • 5
  • [ 860554-21-8 ]
  • [ 107806-82-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: aqueous KOH-solution
  • 6
  • [ 860575-80-0 ]
  • [ 107806-82-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: iron; aqueous acetic acid 2: aqueous KOH-solution
  • 7
  • [ 586-89-0 ]
  • [ 107806-82-6 ]
YieldReaction ConditionsOperation in experiment
63% With oxygen; potassium acetate; palladium diacetate; p-benzoquinone In N,N-dimethyl acetamide at 115℃; for 15h;
63% With oxygen; potassium acetate; p-benzoquinone In ISOPROPYLAMIDE at 115℃; for 15h; III III. General procedure for Pd (II) -catalyzedorfcho-hydroxylation with 5 atm 02 :A 50 mL high pressure reactor equipped with a magnetic stir bar was charged with Pd(OAc)2 (11.2 mg, 0.05 mmol), followed by the benzoic acidsubstrate (0.5 mmol), benzoquinone (54.0 mg, 0.5 mmol), KOAc (98.0 mg, 1 mmol) andN, N-dimethylacetamide (1.5 mL) . The reactor was filled with 02 (20 atm) , and then evacuated and backed-filled with 02 (5 atm, 2 times) . After the reaction mixture was stirred at 115 °C for 15 hours, it was permitted to cool to ambient temperature. The reaction was worked up and the crude product was purified following the procedure described above for hydroxylation with 1 atm O2.
51% With oxygen; potassium acetate; palladium diacetate; p-benzoquinone In N,N-dimethyl acetamide at 115℃; for 24h; Schlenk technique;
  • 8
  • [ 487-70-7 ]
  • [ 107806-82-6 ]
  • C16H12O7 [ No CAS ]
YieldReaction ConditionsOperation in experiment
84.9% With sodium hydroxide In water Inert atmosphere; Reflux; 11 2-hydroxy-4-acetylbenzoic acid (1.15)and 2,4,6-trihydroxybenzoic acidAldehyde (0.98 g, 6.36 mmol) was added to a one-necked flask, and 10 ml of a 20% aqueous solution of sodium hydroxide was added thereto, followed by magnetic stirring. oil bathThe reaction was warmed to reflux and the reaction was complete by TLC. After cooling, the reaction solution was poured into 100 ml of ice water and adjusted to pH with dilute hydrochloric acid. The organic phase was washed with water (3 X 30 mL), dried over anhydrous sodium sulphate, filtered, and concentrated under reduced pressureTo give the compound 11 in a yield of 84.9%.
  • 9
  • [ 487-70-7 ]
  • [ 107806-82-6 ]
  • C28H32O17 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sodium hydroxide / water / Inert atmosphere; Reflux 2: scandium tris(trifluoromethanesulfonate) / water / Inert atmosphere; Reflux
  • 10
  • [ 107806-82-6 ]
  • 6-acetyl-2-(2-hydroxypropan-2-yl)benzofuran-3(2H)-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: sulfuric acid / 12 h / Reflux 2: potassium carbonate / acetone / 3 h / Reflux 3: sodium; methanol / 2 h / Reflux 4: lithium hydroxide monohydrate / dimethyl sulfoxide; water / 3 h / 75 °C 5: aluminum oxide / 0.5 h / 20 °C
  • 11
  • [ 107806-82-6 ]
  • methyl 4-acetyl-2-(2-methoxy-2-oxoethoxy)benzoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sulfuric acid / 12 h / Reflux 2: potassium carbonate / acetone / 3 h / Reflux
  • 12
  • [ 107806-82-6 ]
  • (2R,3S)-6-((R)-1-hydroxyethyl)-2-(2-hydroxypropan-2-yl)-2,3-dihydrobenzofuran-3-ol [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1: sulfuric acid / 12 h / Reflux 2: potassium carbonate / acetone / 3 h / Reflux 3: sodium; methanol / 2 h / Reflux 4: lithium hydroxide monohydrate / dimethyl sulfoxide; water / 3 h / 75 °C 5: aluminum oxide / 0.5 h / 20 °C 6: Noyori's catalyst; sodium formate; cetyltrimethylammonim bromide / methanol / 12 h / 65 °C / Inert atmosphere
  • 13
  • [ 107806-82-6 ]
  • (±)-6-(1-hydroxyethyl)-2-(2-hydroxypropan-2-yl)-2,3-dihydrobenzofuran-3-ol [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1: sulfuric acid / 12 h / Reflux 2: potassium carbonate / acetone / 3 h / Reflux 3: sodium; methanol / 2 h / Reflux 4: lithium hydroxide monohydrate / dimethyl sulfoxide; water / 3 h / 75 °C 5: aluminum oxide / 0.5 h / 20 °C 6: sodium tetrahydroborate / methanol / 2 h / 0 °C
  • 14
  • [ 107806-82-6 ]
  • methyl 6-acetyl-3-hydroxybenzofuran-2-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: sulfuric acid / 12 h / Reflux 2: potassium carbonate / acetone / 3 h / Reflux 3: sodium; methanol / 2 h / Reflux
  • 15
  • [ 107806-82-6 ]
  • 6-acetylbenzofuran-3(2H)-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: sulfuric acid / 12 h / Reflux 2: potassium carbonate / acetone / 3 h / Reflux 3: sodium; methanol / 2 h / Reflux 4: lithium hydroxide monohydrate / dimethyl sulfoxide; water / 3 h / 75 °C
  • 16
  • [ 67-56-1 ]
  • [ 107806-82-6 ]
  • [ 27475-11-2 ]
  • 17
  • [ 27475-11-2 ]
  • [ 107806-82-6 ]
YieldReaction ConditionsOperation in experiment
78% With lithium hydroxide monohydrate; lithium hydroxide monohydrate In tetrahydrofuran; methanol at 20℃; 181 Intermediate 4: 2-(1-((5-(1-methyl-1H-indazole-5-carboxamido)-1H-benzo[d]imidazol-2- yl)methyl)pyrrolidin-3-yl)acetic acid General procedure: To a solution of intermediate 3 (300 mg, 0.67mmol) in 5 mL MeOH, 5 mL H2O, and 5 mL THF, LiOH (30 mg, 1 mmol) was added. The mixture was stirred at RT overnight. Then the mixture was purified by reverse phase C18 column (10% - 100% methanol / 0.1% TFA in water) to afford intermediate 4 as white solid in TFA salt form (486 mg, 89%).
78% With lithium hydroxide monohydrate; lithium hydroxide monohydrate In tetrahydrofuran; methanol at 20℃; 181 Intermediate 4: 2-(1-((5-(1-methyl-1H-indazole-5-carboxamido)-1H-benzo[d]imidazol-2- yl)methyl)pyrrolidin-3-yl)acetic acid General procedure: To a solution of intermediate 3 (300 mg, 0.67mmol) in 5 mL MeOH, 5 mL H2O, and 5 mL THF, LiOH (30 mg, 1 mmol) was added. The mixture was stirred at RT overnight. Then the mixture was purified by reverse phase C18 column (10% - 100% methanol / 0.1% TFA in water) to afford intermediate 4 as white solid in TFA salt form (486 mg, 89%).
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