Home Cart Sign in  
Chemical Structure| 108494-56-0 Chemical Structure| 108494-56-0

Structure of 108494-56-0

Chemical Structure| 108494-56-0

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 108494-56-0 ]

CAS No. :108494-56-0
Formula : C10H8FNO
M.W : 177.18
SMILES Code : O=C1C=CN(C)C2=C1C=C(F)C=C2

Safety of [ 108494-56-0 ]

Application In Synthesis of [ 108494-56-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 108494-56-0 ]

[ 108494-56-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 391-78-6 ]
  • [ 74-88-4 ]
  • [ 108494-56-0 ]
YieldReaction ConditionsOperation in experiment
With ammonia; potassium carbonate; In tetrahydrofuran; water; (a) Iodomethane (6.9 ml) was added to a stirred suspension of <strong>[391-78-6]6-fluoro-4-hydroxyquinoline</strong> (16.3 g) and anhydrous potassium carbonate (15.2 g) in dry tetrahydrofuran (100 ml) at ambient temperature and stirring was continued for 18 hours. More iodomethane (1.8 ml) and anhydrous potassium carbonate (3.8 g) were added and stirring was continued for 4 hours at ambient temperature. Concentrated aqueous ammonia (specific gravity 0.88; 100 ml) was added and the mixture was evaporated to dryness. The residue was treated with water (200 ml) and extracted with dichloromethane (2*400 ml). The extract was dried and evaporated to dryness. The residue was crystallized from ethyl acetate to give the novel compound 6-fluoro-1-methyl-4-quinolone, m.p. 88-89.
 

Historical Records

Technical Information

Categories