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Chemical Structure| 1087794-62-4 Chemical Structure| 1087794-62-4

Structure of 1087794-62-4

Chemical Structure| 1087794-62-4

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Product Details of [ 1087794-62-4 ]

CAS No. :1087794-62-4
Formula : C9H6Cl2F3N
M.W : 256.05
SMILES Code : FC(F)(F)C/C(Cl)=N/C1=CC=CC=C1Cl
MDL No. :MFCD11201008

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Application In Synthesis of [ 1087794-62-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1087794-62-4 ]

[ 1087794-62-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1087794-62-4 ]
  • [ 221044-05-9 ]
  • 11-(pyrimidin-2-yl)-6-(trifluoromethyl)-11H-indolo[3,2-c]quinolone [ No CAS ]
YieldReaction ConditionsOperation in experiment
82% With palladium diacetate; potassium carbonate; tris(para-trifluoromethyl)phenyl phosphine; In toluene; at 1120℃; for 16h;Schlenk technique; Inert atmosphere; In a 25mL Schlenk reaction tube, mix 39.0mg N-pyrimidine indole (0.2mmol, 1.0 equivalent), 192.8mg o-chlorofluoroacetyl chloroimide (0.8mmol, 4.0 equivalent), 4.5mg palladium acetate (0.02mmol, 10mol%), 18.7mg of tris(4-trifluorotolyl)phosphine (0.04mmol, 20mol%) and 55.3mg of potassium carbonate (0.4mmol, 2.0 equivalent) were dissolved in 2mL of toluene.Subsequently, the air in the system was replaced with nitrogen, and the reaction system was heated to 120C.After the reaction for 16 hours, the reaction was cooled to room temperature, added silica gel and spin-dried, followed by column chromatography (eluent: a mixture of petroleum ether and ethyl acetate) to obtain the product N-(2-pyrimidinyl)indolo [3, 2-c]-2-trifluoromethylquinoline.
 

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