Home Cart Sign in  
Chemical Structure| 1089706-28-4 Chemical Structure| 1089706-28-4

Structure of 1089706-28-4

Chemical Structure| 1089706-28-4

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 1089706-28-4 ]

CAS No. :1089706-28-4
Formula : C8H6BrFO2
M.W : 233.04
SMILES Code : CC(C1=CC(Br)=CC(F)=C1O)=O
MDL No. :MFCD16742826

Safety of [ 1089706-28-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 1089706-28-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1089706-28-4 ]

[ 1089706-28-4 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 22929-52-8 ]
  • [ 1089706-28-4 ]
  • 6-bromo-8-fluoro-2,2-tetrahydrospirofuranylchroman-4-one [ No CAS ]
  • 6-bromo-8-fluoro-2,2-tetrahydrospirofuranylchroman-4-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
With pyrrolidine; In acetonitrile; at 60℃; for 0.333333h;Microwave irradiation; l-(5-Bromo-3-fluoro-2-hydroxyphenyl)ethanone (0.200 g, 0.858 mmol), dihydrofuran- 3(2H)-one (0.222 g, 2.57 mmol), and pyrrolidine (0.142 ml, 1.72 mmol) were dissolved in MeCN (0.5 mL) and heated in the microwave for 20 minutes fixed at 60 0C. After cooling, the reaction was diluted with EtOAc and washed with IN HCl. The aqueous layer was extracted with EtOAc. The organic layers were combined, washed with water, brine, dried over sodium sulfate, and concentrated. The crude product was purified by silica gel chromatography (1 :4 EtOAc/hexanes) to afford the titled products. MS m/z: 301.0 (100percent, M).
  • 2
  • [ 22929-52-8 ]
  • [ 1089706-28-4 ]
  • 6-bromo-8-fluoro-2,2-tetrahydrospirofuranylchroman-4-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
With pyrrolidine; In acetonitrile; at 60℃; for 0.333333h;microwave irradiation; l-(5-Bromo-3-fluoro-2-hydroxyphenyl)ethanone (0.200 g, 0.858 mmol), dihydrofuran- 3(2H)-one (0.222 g, 2.57 mmol), and pyrrolidine (0.142 ml, 1.72 mmol) were dissolved in MeCN (0.5 mL) and heated in the microwave for 20 minutes fixed at 60 0C. After cooling, the reaction was diluted with EtOAc and washed with IN HCl. The aqueous layer was extracted with EtOAc. The organic layers were combined, washed with water, brine, dried over sodium sulfate, and concentrated. The crude product was purified by silica gel chromatography (1 :4 EtOAc/hexanes) to afford the titled products. MS m/z: 301.0 (100percent, M).
  • 3
  • [ 22929-52-8 ]
  • [ 1089706-28-4 ]
  • [ 1089706-36-4 ]
YieldReaction ConditionsOperation in experiment
With pyrrolidine; In acetonitrile; at 60℃; for 0.333333h;Microwave irradiation; Step 1: 6-Bromo-8-fluoro-2,2-tetrahydrospirofuranylchroman-4-one 1-(5-Bromo-3-fluoro-2-hydroxyphenyl)ethanone (0.200 g, 0.858 mmol), <strong>[22929-52-8]dihydrofuran-3(2H)-one</strong> (0.222 g, 2.57 mmol), and pyrrolidine (0.142 ml, 1.72 mmol) were dissolved in MeCN (0.5 mL) and heated in the microwave for 20 minutes fixed at 60° C. After cooling, the reaction was diluted with EtOAc and washed with 1N HCl. The aqueous layer was extracted with EtOAc. The organic layers were combined, washed with water, brine, dried over sodium sulfate, and concentrated. The crude product was purified by silica gel chromatography (1:4 EtOAc/hexanes) to afford the titled products. MS m/z: 301.0 (100percent, M).
 

Historical Records