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Chemical Structure| 1093092-14-8 Chemical Structure| 1093092-14-8

Structure of 1093092-14-8

Chemical Structure| 1093092-14-8

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Product Details of [ 1093092-14-8 ]

CAS No. :1093092-14-8
Formula : C6H2BrCl2F
M.W : 243.89
SMILES Code : FC1=CC=C(Br)C(Cl)=C1Cl
MDL No. :MFCD11845895
InChI Key :CBJHQGPVASQJFW-UHFFFAOYSA-N
Pubchem ID :50997827

Safety of [ 1093092-14-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 1093092-14-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1093092-14-8 ]

[ 1093092-14-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1093092-14-8 ]
  • [ 57260-71-6 ]
  • [ 1093092-09-1 ]
YieldReaction ConditionsOperation in experiment
With sodium t-butanolate;tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 140.0℃; for 1.0h;Microwave irradiation; A mixture of <strong>[1093092-14-8]1-bromo-2,3-dichloro-4-fluorobenzene</strong> (1.23g) (Aldrich), N-BOC-piperazine (1.03g, 1.1 equivs), Pd2(dba)3 (92mg, 2mol%), BINAP (167mg, 5mol%) and NaOtBu (727mg, 1.5 equivs) in toluene (15ml_) was heated to 1400C for 1 hr using a microwave reactor. The reaction mixture was then diluted with EtOAc and washed with water and the organic phase further washed with bicarbonate solution and dried using Na2SO4. Concentration of the organic phase gave the crude product which was purified on silica to afford the title compound (3.77g); 1H NMR (CDCI3): 7.04 (1 H, m), 6.93 (1 H, m), 3.60 (4H, brs), 2.93 (4H, brs), 1.49 (9H, s).
  • 2
  • [ 1093092-14-8 ]
  • 1-(2,3-dichloro-4-fluorophenyl)piperazine hydrochloride [ No CAS ]
 

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