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Chemical Structure| 109882-26-0 Chemical Structure| 109882-26-0

Structure of 109882-26-0

Chemical Structure| 109882-26-0

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Product Details of [ 109882-26-0 ]

CAS No. :109882-26-0
Formula : C16H23Cl2N3O3
M.W : 376.28
SMILES Code : O=C(O)CCCC1=NC2=CC(N(CCCl)CCO)=CC=C2N1C.[H]Cl

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Application In Synthesis of [ 109882-26-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 109882-26-0 ]

[ 109882-26-0 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 3543-75-7 ]
  • [ 109882-29-3 ]
  • [ 109882-26-0 ]
  • 2
  • [ 109882-26-0 ]
  • [ 3543-75-7 ]
  • C33H43Cl3N6O4*2ClH [ No CAS ]
YieldReaction ConditionsOperation in experiment
236mg With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 20℃; for 4h; Bendamustine hydrochloride (a compound of Formula I, 506mg), single-hydroxyphenyl <strong>[3543-75-7]<strong>[3543-75-7]bendamustine</strong> hydrochloride</strong> (Formula II compound, 508mg), DMSO (5ml), EDCI (503mg) and DMAP (254mg) added to the reaction flask reaction at room temperature for 3 hours, and purified by column chromatography.Specific chromatography conditions: silica gel, octadecyl silane bonded silica gel (ODS-C18), Dilute hydrochloric acid mobile phase (pH 2): acetonitrile = 10: 1 (volume ratio), flow rate 5ml / min, collect the appropriate components below 5 concentrated and lyophilized to give 236mg compound III, HPLC purity 98.6%.
  • 3
  • [ 3543-75-7 ]
  • [ 109882-26-0 ]
YieldReaction ConditionsOperation in experiment
0.35 g Bendamustine hydrochloride (compound of formula I, 1 g) and 5% K2CO 35 ml were mixed and heated to 25 C. Reaction 1Hour, with 3mol / L hydrochloric acid solution to adjust the pH to 5, adding acetonitrile, filtration, mother liquor by column chromatography purification. With(ODS-C18). The mobile phase was dilute hydrochloric acid (pH 5): BNitrile = 3: 1 (volume ratio) at a flow rate of 2 ml / min. The respective fractions were collected, concentrated under reduced pressure at 10 C or lower, lyophilized,0.35 g of compound II was obtained and the HPLC purity was 99.5%.
 

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