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Chemical Structure| 110005-81-7 Chemical Structure| 110005-81-7

Structure of 110005-81-7

Chemical Structure| 110005-81-7

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Product Details of [ 110005-81-7 ]

CAS No. :110005-81-7
Formula : C9H10O3
M.W : 166.17
SMILES Code : O=CC1=CC(CCO)=CC=C1O

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Application In Synthesis of [ 110005-81-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 110005-81-7 ]

[ 110005-81-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 110005-81-7 ]
  • [ 83883-26-5 ]
  • C41H46O11 [ No CAS ]
YieldReaction ConditionsOperation in experiment
29% With dmap; diisopropyl-carbodiimide; In dichloromethane; at 5 - 25℃; (Synthesis of Compound 1-c-la) To a 50-mi three-necked flask, 1.03 g of 5-(2-hydroxy)ethyl-2-hydroxybenzaldehyde, 3.55 g of 4-(6-acryloyloxy)hexyloxybenzoic acid, 0.07 g of N,N-dimethylaminopyridine (DMAP), and 15 ml of dichloromethane were added. The resulting mixture was stirred at 5° C. to 10° C. for 10 minutes. While the mixture was stirred, 1.9 g of N,N-diisopropylcarbodiimide (DIC) was added dropwise to the mixture such that the temperature was maintained to be 5° C. to 10° C. Subsequently, the tempera- tare was increased to 25° C., and stirring was performed for 7 hours. To the resulting reaction mixture, 15 ml of water was added and an organic layer was separated. Then, an aqueous layer was extracted with 15 ml of dichloromethane. To the combined organic layer were added 90 ml of hexane and 2 g of silica gel, and the resulting solid-liquid mixture was stirred. The solid-liquid mixture was charged into a column filled with 5 g of silica gel and 5 g of alumina and passed through the column. After the solvent of the resulting solution had been substantially distilled away, reprecipitation was performed with acetone/methanol. The resulting crystals were filtered and dried to form 1.23 g of the compound (1-c-la) (yield: 29percent).(Synthesis of Compound l-c-l) To a 30-mi three-necked flask, 1.4 g of the compound (1-c-la), 0.35 g of 2-hy- drazinobenzothiazole, and 5 ml of tetrahydrofuran were added. The resulting mixture was stirred at 25° C. for 9 hours. Subsequently, 50 ml of water was added to the mixture, and extraction with 30 ml of ethyl acetate was performed twice. The resulting organic phase was dried using sodium sulfate. After sodium sulfate had been removed by filtration, vacuum concentration was performed. The resulting residue was purified by silica-gel colunm chromatography (hexane/ethyl acetate: 2/1). The resulting crude product was reprecipitated with acetone/methanol. The resulting crystals were filtered and dried to form 0.98 g of the compound (l-c-l).The upper-limit temperature of the phase sequence of the polymerizable compound (1 -c-l) which was determined by differential scanning calorimetry and observing the liquid crystal phase with a polarized light microscope equipped with a temperature-controllable apparatus was ?Sm 60 Iso?.?H NMR (CDC13) delta1.40-1.60 (p, 8H), 1.6 (br,1H), 1.65-1.80 (p, 4H), 1.80-1.97 (p, 4H), 3.15 (t, 2H), 4.01(t, 2H), 4.17 (t, 2H), 4.31 (t, 2H), 4.40 (t, 2H), 4.57 (t, 2H),5.81-5.85 (d+d, 2H), 6.08-6.18 (m, 2H), 6.37-6.46 (d+d,2H), 6.87 (d, 2H), 6.96 (d, 2H), 7.12-7.18 (m, 2H), 7.34 (d,1H), 7.48 (d, 1H), 7.58 (d, 1H), 7.99-8.02 (s+d, 5H), 8.12 (d,2H).LC-MS: mlz 862.60[M+]
  • 2
  • [ 110005-81-7 ]
  • [ 83883-26-5 ]
  • C48H51N3O10S [ No CAS ]
 

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Technical Information

• Appel Reaction • Barbier Coupling Reaction • Baylis-Hillman Reaction • Bucherer-Bergs Reaction • Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Chugaev Reaction • Clemmensen Reduction • Complex Metal Hydride Reductions • Corey-Chaykovsky Reaction • Corey-Fuchs Reaction • Corey-Kim Oxidation • Dess-Martin Oxidation • Fischer Indole Synthesis • Grignard Reaction • Hantzsch Dihydropyridine Synthesis • Henry Nitroaldol Reaction • Horner-Wadsworth-Emmons Reaction • Hydride Reductions • Jones Oxidation • Julia-Kocienski Olefination • Knoevenagel Condensation • Leuckart-Wallach Reaction • Martin's Sulfurane Dehydrating Reagent • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Mitsunobu Reaction • Moffatt Oxidation • Mukaiyama Aldol Reaction • Nozaki-Hiyama-Kishi Reaction • Oxidation of Alcohols by DMSO • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Alcohols • Preparation of Aldehydes and Ketones • Preparation of Amines • Prins Reaction • Reactions of Alcohols • Reactions of Aldehydes and Ketones • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions with Organometallic Reagents • Reformatsky Reaction • Ritter Reaction • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Sharpless Olefin Synthesis • Stetter Reaction • Stobbe Condensation • Swern Oxidation • Tebbe Olefination • Ugi Reaction • Wittig Reaction • Wolff-Kishner Reduction

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