Alternatived Products of [ 1100207-81-5 ]
Product Details of [ 1100207-81-5 ]
CAS No. : | 1100207-81-5 |
MDL No. : | MFCD16987765 |
Formula : |
C9H6BrClN2
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
257.51
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 1100207-81-5 ]
Signal Word: | |
Class: | |
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Application In Synthesis of [ 1100207-81-5 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1100207-81-5 ]
- 1
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[ 215115-09-6 ]
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[ 1100207-81-5 ]
Yield | Reaction Conditions | Operation in experiment |
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8-bromo-4-chloro-6-methylquinazoline. A mixture of neat 2-amino-3-bromo-5-methylbenzoic acid (2 g, 8.69 mmol) and formamidine acetate (1.005 g, 9.65 mmol) was heated with a heat gun and shaking in a 100 ml round bottom flask under a N2 balloon until the material was melted together (4 minutes). To the crude <strong>[215115-09-6]8-bromo-6-methylquinazolin-4(3H)-one</strong> (1.68 g) was added POCl3 (13 mL, 139 mmol) and the mixture was heated at reflux overnight. Excess POCl3 was removed by rotovap and ice was added to the residue. The pH of the mixture was neutralized to pH 7 using NaOH and saturated aqueous Na2CO3. The aqueous layer was then extracted with EtOAc, washed with brine, dried over MgSO4 and concentrated. Purification of the crude residue by column chromatography (SiO2) eluding with 0-20% EtOAc in hexanes gave the product (1.24 g, 4.82 mmol, 55%). 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 9.09 (1H, s), 8.12 (1H, d, J=1.76 Hz), 8.01 (1H, d, J=1.01 Hz), 2.59 (3H, s). Mass 258.97 [M+H]+. |