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Chemical Structure| 1105510-11-9 Chemical Structure| 1105510-11-9

Structure of 1105510-11-9

Chemical Structure| 1105510-11-9

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Product Details of [ 1105510-11-9 ]

CAS No. :1105510-11-9
Formula : C6H5F2NO
M.W : 145.11
SMILES Code : OCC1=CC=C(F)N=C1F
MDL No. :MFCD12911481

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  • Downstream synthetic route of [ 1105510-11-9 ]

[ 1105510-11-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 171178-50-0 ]
  • [ 1105510-11-9 ]
YieldReaction ConditionsOperation in experiment
96% With dimethylsulfide; diborane; In tetrahydrofuran; at 0 - 10℃; for 3h;Inert atmosphere; To a solution of <strong>[171178-50-0]2,6-difluoropyridine-3-carboxylic acid</strong> (8 g, 50 mmol) in tetrahydrofuran (100 ml) at 0 C under nitrogen atmosphere was slowly added 10 M borane in (0355) dimethylsulfide (20 ml, 201 mmol). After addition, the reaction mixture was stirred at 10C for 3 h, cooled to 0 C, and treated with drop- wise addition of methanol (15 ml). The mixture was heated to 40 C for 30 min, concentrated and purified by silica gel column (eluting gradient: 8%-10% methanol: dichloromethane) to afford (2,6-difluoro-3-pyridyl)methanol (7.0 g, 96%) as a colorless oil. 1H NMR (400 MHz, DMSO-J6) δ 8.18 - 8.11 (m, 1H), 7.16 (dd, / = 8.0 Hz, 2.0 Hz, 1H), 5.47 (t, / = 5.2 Ηζ, ΙΗ), 4.52 (d, / = 5.2 Hz, 2H).
 

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