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[ CAS No. 1111638-41-5 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
Chemical Structure| 1111638-41-5
Chemical Structure| 1111638-41-5
Structure of 1111638-41-5 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1111638-41-5 ]

CAS No. :1111638-41-5 MDL No. :N/A
Formula : C7H7BrClNO Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 236.49 Pubchem ID :-
Synonyms :

Safety of [ 1111638-41-5 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1111638-41-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1111638-41-5 ]
  • Downstream synthetic route of [ 1111638-41-5 ]

[ 1111638-41-5 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 1111638-41-5 ]
  • [ 886365-47-5 ]
YieldReaction ConditionsOperation in experiment
77% With pyridine; chromium(VI) oxide In dichloromethane at 0 - 20℃; Silica gel Preparation of 1-(5-bromo-2-chloropyridin-3-yl)ethanone (D-2-5). <n="106"/>To a stirred solution of pyridine (13 g, 0.165 mol) in CH2CI2 (200 mL) was added CrO3 (8.25 g, 0.083 mol) and silica gel (20 mL) portionwise at 0 °C. After the addition, the reaction mixture was stirred for 10 minutes. Compound D-2-4 (6.5 g, 27.5 mmol) was then added and the resulting mixture was stirred at room temperature overnight. TLC (petroleum ether/EtOAc 8:1 ) indicated most of compound D-2-4 was consumed. The reaction mixture was filtered and the filtrate was concentrated in vacuo to give crude compound D-2-5, which was purified by column chromatography (silica gel petroleum ether/EtOAc 20:1) to give pure compound D-2-5 (5 g, yield: 77percent) as a yellow oil.
Reference: [1] Patent: WO2009/16460, 2009, A2, . Location in patent: Page/Page column 104-105
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