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Structure of 1112193-37-9

Chemical Structure| 1112193-37-9

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Product Details of [ 1112193-37-9 ]

CAS No. :1112193-37-9
Formula : C7H8N2O
M.W : 136.15
SMILES Code : C12=NC=CC=C1NCCO2
MDL No. :MFCD08692103
InChI Key :LTWFBZQFHPDLNU-UHFFFAOYSA-N
Pubchem ID :15127902

Safety of [ 1112193-37-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H319
Precautionary Statements:P305+P351+P338

Application In Synthesis of [ 1112193-37-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1112193-37-9 ]

[ 1112193-37-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1112193-37-9 ]
  • [ 3337-62-0 ]
  • [ 1198153-12-6 ]
YieldReaction ConditionsOperation in experiment
31% d) Synthesis of (3,5-dibromo-4-hydroxy-phenyl)-(2,3-dihydro-pyrido[2,3-b][1,4]oxazin-1-yl)-methanone <strong>[3337-62-0]3,5-dibromo-4-hydroxy-benzoic acid</strong> (65 mg, 0.22 mmol) was dissolved in N,N-dimethyl acetamide (1.5 ml) and then cooled to -5.box.. Thionyl chloride (0.024 ml, 0.33 mmol) was added thereto and stirred at -5.box. for 30 minutes. 2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine dissolved in N,N-dimethyl acetamide (0.7 ml) was added thereto and then stirred at -5.box. for 20 minutes, and subsequently stirred at room temperature for 15 hours. Water was added and the mixture was extracted with dichloromethane, and then the (extracted) combined organic layer was dried over anhydrous sodium sulfate (Na2SO4), filtered and evaporated under reduced pressure. The residue was purified by column chromatography on silica eluding with a solvent of n-hexane:ethyl acetate=1:1. The fractions containing the product were collected and evaporated to obtain pale-yellow solid (28 mg, 31percent). 1H-NMR (CDCl3, 300 MHz); delta=10.58 (s, 1H), 7.93 (dd, J=4.6 Hz, 1.5 Hz, 1H), 7.81-7.55 (m, 3H), 6.92 (dd, J=8.0 Hz, 4.6 Hz, 1H), 4.41 (m, 2H), 3.87 (m, 2H). MS (ESI); 412.9 (M++1).
 

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[ 1112193-37-9 ]

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