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Chemical Structure| 1112982-70-3 Chemical Structure| 1112982-70-3

Structure of 1112982-70-3

Chemical Structure| 1112982-70-3

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Product Details of [ 1112982-70-3 ]

CAS No. :1112982-70-3
Formula : C9H5BrFNO2S2
M.W : 322.17
SMILES Code : O=S(C1=NC(Br)=CS1)(C2=CC=C(F)C=C2)=O
MDL No. :MFCD32690723

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Application In Synthesis of [ 1112982-70-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1112982-70-3 ]

[ 1112982-70-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1112982-70-3 ]
  • [ 885069-14-7 ]
  • [ 1112980-18-3 ]
YieldReaction ConditionsOperation in experiment
With sodium carbonate;tetrakis(triphenylphosphine) palladium(0); In 1,4-dioxane; water; at 95℃; Step 3. N-(6-(2-(4-Fluorophenylsulfonyl')thiazol-4-yl)benzordlthiazol-2-yl)acetamide; A RBF was charged with N-(6-(4,4,5,5-tetramethyl-l ,3,2-dioxaborolan-2-yl)benzo[d]thiazol-2- yl)acetamide (0.5 g, 1 mmol), 4-bromo-2-(4-fluorophenylsulfonyl)thiazole (0.4 g, 1 mmol), 2 M Na2CO3 (1 mL, 2 mmol), tetrakis(triphenylphosphine)palladium(0) (0.2 g, 0.2 mmol), and dioxane (6 mL). The flask was placed into a pre-heated (95 C) bath and allowed to stir under an inert atmosphere overnight.The mixture was diluted with DMSO and filtered. The crude was purified by reverse-phase HPLC to give N-(6-(2-(4-fluorophenylsulfonyl)thiazol-4-yl)benzo[d]thiazol-2-yl)acetamide as an off-white solid. MS (ESI pos. ion) m/z: 434 (MH+). Calculated exact mass for C18H12FN3O3S3: 433. 1H NMR (400 MHz, DMSO-^6): 8.53 (s, 1H), 8.30 (s, 1H), 8.21 (s, 2H), 7.81 (s, 1H), 7.56 (s, 3H), 2.07 (s, 3H).
 

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