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[ CAS No. 111600-89-6 ] {[proInfo.proName]}

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Chemical Structure| 111600-89-6
Chemical Structure| 111600-89-6
Structure of 111600-89-6 * Storage: {[proInfo.prStorage]}
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Product Details of [ 111600-89-6 ]

CAS No. :111600-89-6 MDL No. :MFCD18207415
Formula : C5H3NS Boiling Point : -
Linear Structure Formula :- InChI Key :SNNHMXYMKWHUBM-UHFFFAOYSA-N
M.W : 109.15 Pubchem ID :22238491
Synonyms :

Safety of [ 111600-89-6 ]

Signal Word:Warning Class:
Precautionary Statements:P501-P210-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313-P403+P235 UN#:
Hazard Statements:H315-H319-H227 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 111600-89-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 111600-89-6 ]

[ 111600-89-6 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 34259-99-9 ]
  • [ 1066-54-2 ]
  • [ 111600-89-6 ]
  • 2
  • [ 111600-89-6 ]
  • [ 73852-88-7 ]
  • [ 1071794-98-3 ]
YieldReaction ConditionsOperation in experiment
With potassium acetate; triethylamine;bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In dichloromethane; for 3h; Intermediate 7; 4-[4-(4,4,5,5-Tetramethyl-1 ,3,2-dioxaborolan-2-yl)phenyl]ethynyl}-1 ,3-thiazole; A mixture of Intermediate 5 (709 mg), Intermediate 6 (925 mg), potassium acetate (935 mg), copper(l) iodide (30 mg) and 1 ,1-bis(triphenylphosphino) dichloropalladium (II) (95 mg) in DCM (25 ml.) was stirred and treated with triethylamine (6 ml.) for 3 h. The reaction mixture was washed with water (50 ml_), the DCM layer was separated using a hydrophobic frit and concentrated. The residue was then purified by ISCO Companion chromatography silica chromatography, eluting with a gradient of EtOAc / cyclohexane (10% to 100%) to give the title compound. 1H NMR (CDCI3): delta 8.83 (1 H, d), 7.80 (2H, d), 7.60 (1 H, d), 7.58 (2h, d), 1.36 (12H, s).
  • 3
  • [ 3364-80-5 ]
  • [ 1034-49-7 ]
  • [ 111600-89-6 ]
YieldReaction ConditionsOperation in experiment
Example 36; 4-((Z)-2-Tritylthioethen-1-yl)thiazole; a) 4-Ethynylthiazole; Bromomethyltriphenylphosphonium bromide (9.83 g) was added to 100 ml of a suspension of 7.27 g of potassium-t-butoxide in THF under ice cooling, the suspension was stirred at the same temperature for 10 min, and 2.44 g of 4-formylthiazole was further added thereto. The mixture was stirred at room temperature for 2 hr. Thereafter, 100 ml of ethyl acetate and 100 ml of semi-saturated brine were added thereto, followed by separation. The organic layer was then washed with semi-saturated brine. The organic layer was dried over anhydrous magnesium sulfate, the solvent was removed by distillation under the reduced pressure, and the residue was purified by column chromatography on silica gel (dichloromethane:hexane=3:2) to give 614 mg of 4-ethynylthiazole. NMR (CDCl3) delta: 3.15 (1H, s), 7.58 (1H, d, J=2.0 Hz), 8.78 (1H, d, J=2.0 Hz)
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