Alternatived Products of [ 113853-92-2 ]
Product Details of [ 113853-92-2 ]
CAS No. : | 113853-92-2 |
MDL No. : | MFCD07369339 |
Formula : |
C10H14BrNO2
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
260.13
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 113853-92-2 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 113853-92-2 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 113853-92-2 ]
- 1
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[ 17608-10-5 ]
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[ 113853-92-2 ]
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[ 138977-28-3 ]
Yield | Reaction Conditions | Operation in experiment |
79% |
With triethylamine In tetrahydrofuran for 18h; |
|
70% |
With triethylamine In N,N-dimethyl-formamide at 20℃; for 4h; |
|
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With triethylamine In DMF (N,N-dimethyl-formamide) for 65h; |
10
The hydrobromic salt of the bicyclic amine (1 eq.) was dissolved in DMF and triethylamine (3 eq.) was added. This mixture was stirred for 15-30 minutes and then was the isothiocyanate (1.2 eq.) added. This mixture was stirred for 65 hours and then concentrated. The residue was dissolved in EtOAc and washed with water. The organic phase was dried (MgSO4) and concentrated to give the crude product, typically as a yellow oil. The thiourea was chromatographed on silicagel (heptane:EtOAc). The substituted thioureas thus prepared are listed in Table 5. |
Reference:
[1]Walpole, Christopher S. J.; Bevan, Stuart; Bovermann, Guenter; Boelsterli, Johann J.; Breckenridge, Robin; et al.
[Journal of Medicinal Chemistry, 1994, vol. 37, # 13, p. 1942 - 1954]
[2]Dalence-Guzman, Maria F.; Berglund, Magnus; Skogvall, Staffan; Sterner, Olov
[Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 5, p. 2499 - 2512]
[3]Current Patent Assignee: RESPIRATORIUS - US2005/165004, 2005, A1
Location in patent: Page/Page column 16