[ CAS No. 1142211-17-3 ] {[proInfo.proName]}

Name: 1142211-17-3|tert-Butyl (1-(hydroxymethyl)cyclobutyl)carbamate|95%
Brand: Ambeed
SKU: A251550
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Product Details of [ 1142211-17-3 ]

CAS No. :	1142211-17-3	MDL No. :	MFCD12028429
Formula :	C₁₀H₁₉NO₃	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	CLRGYDRXIYIAHC-UHFFFAOYSA-N
M.W :	201.26	Pubchem ID :	25220830
Synonyms :

Safety of [ 1142211-17-3 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P280-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H332-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 1142211-17-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 1142211-17-3 ]
Downstream synthetic route of [ 1142211-17-3 ]

[ 1142211-17-3 ] Synthesis Path-Upstream 1~8

1
[ 163554-54-9 ]
[ 1142211-17-3 ]

Yield	Reaction Conditions	Operation in experiment
95%	With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at -15 - -10℃; for 2.16667 h; Inert atmosphere	To a solution of ethyl l-((ieri-butoxycarbonyl)amino)cyclobutanecarboxylate (2.97 g, 12.2 mmol) in diethyl ether (50 mL) at -15 °C under nitrogen was added dropwise lithium aluminium hydride (12.8 mL, 25.6 mmol, 2.0 M in THF) over 40 min. The reaction was maintained at -10 °C for 1.5 h then quenched with water (4 mL), 2 N NaOH (5.4 mL) then more water (11 mL). The reaction was warmed to r.t. and stirred for 30 min then MgS0₄ was added and the reaction was filtered through Celite, washing well with ethyl acetate. The filtrate was concentrated to yield the title compound as an off white solid (2.34 g, 95percent).

Reference： [1] Patent: WO2016/179550, 2016, A1, . Location in patent: Paragraph 0191

2
[ 120728-10-1 ]
[ 1142211-17-3 ]

Reference： [1] Patent: WO2010/42850, 2010, A1, . Location in patent: Page/Page column 52-53; 67
[2] Patent: WO2011/44501, 2011, A2, . Location in patent: Page/Page column 60; 76
[3] Patent: WO2011/44498, 2011, A1, . Location in patent: Page/Page column 66, 80-81
[4] Patent: WO2011/44538, 2011, A1, . Location in patent: Page/Page column 105-106
[5] Patent: WO2009/67692, 2009, A1, . Location in patent: Page/Page column 187
[6] Patent: WO2010/42851, 2010, A1, . Location in patent: Page/Page column 52-53; 67
[7] Patent: WO2010/132777, 2010, A2, . Location in patent: Page/Page column 195; 48-49

3
[ 24424-99-5 ]
[ 1142211-17-3 ]

Yield	Reaction Conditions	Operation in experiment
59%	Stage #1: With hydrogenchloride In ethanol; water at 20℃; for 8 h; Reflux; Inert atmosphere Stage #2: With sodium hydrogencarbonate In water; ethyl acetate at 20℃; for 12 h; Inert atmosphere	General procedure: 6 M aqueous HCl (2 ml) was added to asolution of oxazoline 2c (0.158 g, 0.58 mmol) in EtOH(2 ml), and the mixture was stirred for 1 h at roomtemperature, then it was refluxed for 7 h. The solvents wereremoved in vacuo, and saturated aq NaHCO3 solution(10 ml) was added to the residue followed by di-tert-butyldicarbonate (0.275 g, 2.00 mmol) solution in EtOAc(10 ml). The reaction mixture was stirred for 12 h at roomtemprature. The organic phase was separated, and theaquoeus phase was extracted with EtOAc (3 × 10 ml). Thecombined, organic phases were washed with saturated aqNaCl (10 ml) and dried over Na2SO4. The extract wasevaporated and the residue was purified by flash chromatography on silica gel (eluent EtOAc – light petroleum ether,gradient from 1:4 to 1:1).

Reference： [1] Chemistry of Heterocyclic Compounds, 2017, vol. 53, # 9, p. 989 - 996[2] Khim. Geterotsikl. Soedin., 2017, vol. 53, # 9, p. 989 - 996,8

4
[ 880166-10-9 ]
[ 1142211-17-3 ]

Reference： [1] Patent: WO2017/17630, 2017, A1, . Location in patent: Page/Page column 81

5
[ 24424-99-5 ]
[ 1142211-17-3 ]

Reference： [1] Patent: WO2011/44498, 2011, A1,
[2] Patent: WO2010/42851, 2010, A1,

6
[ 39590-81-3 ]
[ 1142211-17-3 ]

Reference： [1] Chemistry of Heterocyclic Compounds, 2017, vol. 53, # 9, p. 989 - 996[2] Khim. Geterotsikl. Soedin., 2017, vol. 53, # 9, p. 989 - 996,8
[3] Chemistry of Heterocyclic Compounds, 2017, vol. 53, # 9, p. 989 - 996[4] Khim. Geterotsikl. Soedin., 2017, vol. 53, # 9, p. 989 - 996,8

7
[ 24424-99-5 ]
[ 1142211-17-3 ]

Reference： [1] Patent: WO2017/17630, 2017, A1,

8
[ 34619-03-9 ]
[ 1142211-17-3 ]

Reference： [1] Patent: WO2016/179550, 2016, A1,

[ 1142211-17-3 ] Synthesis Path-Downstream 1~14

1
[ 120728-10-1 ]
[ 1142211-17-3 ]

Yield	Reaction Conditions	Operation in experiment
		-Boc-1-amino-cyclobutane carboxylic acid (6.28 mmol) was submitted to Procedure 12 for reduction to the corresponding N-Boc-1-Amino-cyclobutyl- methanol.; Procedure 12: Synthesis of alcohols via Borane Reduction To a stirring solution of the acid (1.5 mmol) in THF (5 mL) at -100C was slowly added 1.0 M BH3-THF (2.98 mL, 2.98 mmol). The reaction mixture was stirred vigorously for an additional 3 min at -100C, and was then allowed to warm to room temperature overnight. The reaction was quenched by the dropwise addition of a solution of HOAcZH2O (1 :1 v/v, 2.0 mL). The THF was removed by rotary evaporation and sat. aq. NaHCO3 (15 mL) was added. The aqueous layer was extracted with DCM (3 x 5 mL) and the combined organic layers were washed with sat. aq. NaHCO3 (2 x 5 mL), brine (10 mL), dried over Na2SO4, filtered and concentrated to dryness.
		To a stirring solution of the acid (1.5 mmol) in THF (5 mL) at -10C was slowly added 1.0 M BH3-THF (2.98 mL, 2.98 mmol). The reaction mixture was stirred vigorously for an additional 3 min at -10C, and was then allowed to warm to room temperature overnight. The reaction was quenched by the dropwise addition of a solution of HOAc/H20 (1 :1 v/v, 2.0 mL). The THF was removed by rotary evaporation and sat. aq. NaHC03 (15 mL) was added. The aqueous layer was extracted with DCM (3 x 5 mL) and the combined organic layers were washed with sat. aq. NaHC03 (2 x 5 mL), brine (10 mL), dried over Na2S04, filtered and concentrated to dryness.; N-Boc-l-amino-cyclobutyl-methanolN-Boc-l-amino-cyclobutane carboxylic acid (6.28 mmol) was submitted to Procedure 12 for reduction to the corresponding N-Boc-l-Amino-cyclobutyl- methanol.
		Synthesis of alcohols via Borane Reduction: To a stirring solution of the acid (1.5 mmol) in THF (5 mL) at -10C was slowly added 1.0 M BH3-THF (2.98 mL, 2.98 mmol). The reaction mixture was stirred vigorously for an additional 3 min at -10C, and was then allowed to warm to room temperature overnight. The reaction was quenched by the dropwise addition of a solution of HOAc/H20 (1 :1 v/v, 2.0 mL). The THF was removed by rotary evaporation and sat. aq. NaHC03 (15 mL) was added. The aqueous layer was extracted with DCM (3 x 5 mL) and the combined organic layers were washed with sat. aq. NaHC03 (2 x 5 mL), brine (10 mL), dried over Na2S04, filtered and concentrated to dryness.

	With borane-THF; In tetrahydrofuran; at -10 - 20℃;	N-Boc-l-amino-cyclobutane carboxylic acid (6.28 mmol) was submitted to Procedure 12 for reduction to the corresponding N-Boc-l-Amino-cyclobutyl- methanol.
		Procedure 19: Synthesis of alcohols via Borane ReductionTo a stirring solution of the acid (1.5 mmol) in THF (5 mL) at -100C was slowly added 1.0 M BH3-THF (2.98 mL, 2.98 mmol). The reaction mixture was stirred vigorously for an additional 3 min at -10C, and was then allowed to warm to room temperature overnight. The reaction was quenched by the dropwise addition of a solution of HOAc/H2O (1 :1 v/v, 2.0 mL). The THF was removed by rotary evaporation and sat. aq. NaHCO3 (15 mL) was added. The aqueous layer was extracted with DCM (3 x 5 mL) and the combined organic layers were washed with sat. aq. NaHCO3 (2 x 5 mL), brine (10 mL), dried over Na2SO4, filtered and concentrated to dryness. N-Boc-1-amino-cyclobutyl-methanolN-Boc-1 -amino-cyclobutane carboxylic acid (6.28 mmol) was submitted to Procedure 19 for reduction to the corresponding N-Boc-1 -Amino-cycl obutyl- methanol.
		-Boc-1-amino-cyclobutane carboxylic acid (6.28 mmol) was submitted to Procedure 12 for reduction to the corresponding N-Boc-1-Amino-cyclobutyl- methanol.; Procedure 12: Synthesis of alcohols via Borane Reduction To a stirring solution of the acid (1.5 mmol) in THF (5 mL) at -100C was slowly added 1.0 M BH3-THF (2.98 mL, 2.98 mmol). The reaction mixture was stirred vigorously for an additional 3 min at -100C, and was then allowed to warm to room temperature overnight. The reaction was quenched by the dropwise addition of a solution of HOAcZH2O (1 :1 v/v, 2.0 mL). The THF was removed by rotary evaporation and sat. aq. NaHCO3 (15 mL) was added. The aqueous layer was extracted with DCM (3 x 5 mL) and the combined organic layers were washed with sat. aq. NaHCO3 (2 x 5 mL), brine (10 mL), dried over Na2SO4, filtered and concentrated to dryness.
	With borane-THF; In tetrahydrofuran; at -10 - 20℃;	N-Boc-l-amino-cyclobutyl-methanol N-Boc-l-amino-cyclobutane carboxylic acid (6.28 mmol) was submitted to Procedure 19 for reduction to the corresponding N-Boc-1-Amino-cyclobutyl- methanol. Procedure 19: Synthesis of alcohols via Borane Reduction To a stirring solution of the acid (1.5 mmol) in THF (5 mL) at -1O0C was slowly added 1.0 M BH3-THF (2.98 mL, 2.98 mmol). The reaction mixture was stirred vigorously for an additional 3 min at -10C, and was then allowed to warm to room temperature overnight. The reaction was quenched by the dropwise addition of a solution of HOAc/H2O (1 :1 v/v, 2.0 mL). The THF was removed by rotary evaporation and sat. aq. NaHCO3 (15 mL) was added. The aqueous layer was extracted with DCM (3 x 5 mL) and the combined organic layers were washed with sat. aq. NaHCO3 (2 x 5 mL), brine (10 mL), dried over Na2SO4, filtered and concentrated to dryness

Reference： [1]Patent: WO2010/42850,2010,A1 .Location in patent: Page/Page column 52-53; 67
[2]Patent: WO2011/44501,2011,A2 .Location in patent: Page/Page column 60; 76
[3]Patent: WO2011/44498,2011,A1 .Location in patent: Page/Page column 66, 80-81
[4]Patent: WO2011/44538,2011,A1 .Location in patent: Page/Page column 105-106
[5]Patent: WO2009/67692,2009,A1 .Location in patent: Page/Page column 187
[6]Patent: WO2010/42851,2010,A1 .Location in patent: Page/Page column 52-53; 67
[7]Patent: WO2010/132777,2010,A2 .Location in patent: Page/Page column 195; 48-49

2
[ 1142211-17-3 ]
[ 163554-55-0 ]

Yield	Reaction Conditions	Operation in experiment
96.8%		N-Boc-1-amino-cyclobutane carboxaldehydeN-Boc-l-amino-cyclobutyl-methanol (0.25 g, 1.24 mmol) was submitted to Procedure 18 to yield the corresponding N-Boc-1-amino-cyclobutane carboxaldehyde (0.24 g, 1.20 mmol, 96.8 % yield): 1H NMR (250 MHz, CDC13) delta 9.0 (s, 1 H), 4.91 (bs, 1 H), 3.74 (bs, 2 H), 1.71-2.20 (m, 4 H), 1.42 (s, 9 H).; Procedure 18: Synthesis of Aldehydes via TEMPO/Bleach OxidationTo a vigorously stirring solution of the alcohol (1.54 mmol) in DCM (4 mL) was added TEMPO (0.007 g, 0.045 mmol, 0.03 mol %) and a 2M aqueous KBr solution (75 mL, 0.15 mmol, 10 mol %) and the reaction mixture was cooled to -10C. In a separate flask NaHCO3 (0.5 g, 9.5 mmol) was dissolved in bleach (25 mL, Chlorox 6.0% NaOCl) to yield a 0.78 M buffered NaOCl solution. This freshly prepared 0.78 M NaOCl solution (2.3 mL, 1.8 mmol, 117 mol %) was added to the reaction mixture over 5 min and the reaction was stirred for an additional 30 min at 0C. The organic phase was separated and the aqueous layer was extracted with dichloromethane (2 x 4 mL). The combined organic layers were washed with 10% aq. Na2S2O3 (4 mL), sat. aq. NaHCO3 (2 x 4 mL), brine (5 mL), dried over Na2SO4 and concentrated to dryness.

Reference： [1]Patent: WO2010/132777,2010,A2 .Location in patent: Page/Page column 196; 48

3
[ 24424-99-5 ]
ethyl 1-aminocyclobutanecarboxylate [ No CAS ]
[ 1142211-17-3 ]

Reference： [1]Patent: WO2011/44498,2011,A1
[2]Patent: WO2010/42851,2010,A1

4
[ 1142211-17-3 ]
[ 124-63-0 ]
(1-((tert-butoxycarbonyl)amino)cyclobutyl)methyl methanesulfonate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
98%	With triethylamine; In dichloromethane; at 0 - 25℃; for 12h;Inert atmosphere;	Methanesulfonyl chloride (2.32 mL, 29.81 mmol) was added to <strong>[1142211-17-3]tert-butyl (1-(hydroxymethyl)cyclobutyl)carbamate</strong> (3 g, 14.91 mmol) and triethylamine (5.19 mL,37.26 mmol) in DCM (50 mL) cooled to 0 C under nitrogen. The resulting mixture wasstirred at 25 C for 12 hours then quenched with water (150 mL), extracted with DCM (2 x150 mL), the organic layer was dried over Na2SO4, filtered and evaporated to afford the desired product (1 -((tert-butoxycarbonyl)amino)cyclobutyl)methyl methanesulfonate (4.10 g, 98%) as a white solid. ?HNMR (400 MHz, CDC13, 24C) 1.46 (9H, s), 1.81 - 1.94 (1H, m), 2.01 (1H, dp), 2.20 (4H, t), 3.04 (3H, s), 4.45 (2H, s), 4.83 (1H, s).

Reference： [1]Patent: WO2016/162325,2016,A1 .Location in patent: Page/Page column 197; 198

5
[ 34619-03-9 ]
ethyl 1-aminocyclobutanecarboxylate [ No CAS ]
[ 1142211-17-3 ]

Reference： [1]Patent: WO2016/179550,2016,A1

6
[ 163554-54-9 ]
[ 1142211-17-3 ]

Yield	Reaction Conditions	Operation in experiment
95%	With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at -15 - -10℃; for 2.16667h;Inert atmosphere;	To a solution of ethyl l-((ieri-butoxycarbonyl)amino)cyclobutanecarboxylate (2.97 g, 12.2 mmol) in diethyl ether (50 mL) at -15 C under nitrogen was added dropwise lithium aluminium hydride (12.8 mL, 25.6 mmol, 2.0 M in THF) over 40 min. The reaction was maintained at -10 C for 1.5 h then quenched with water (4 mL), 2 N NaOH (5.4 mL) then more water (11 mL). The reaction was warmed to r.t. and stirred for 30 min then MgS04 was added and the reaction was filtered through Celite, washing well with ethyl acetate. The filtrate was concentrated to yield the title compound as an off white solid (2.34 g, 95%).

Reference： [1]Patent: WO2016/179550,2016,A1 .Location in patent: Paragraph 0191

7
[ 1142211-17-3 ]
(1-aminocyclobutyl)methanol hydrochloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
91%	With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 20℃; for 1h;Inert atmosphere;	To a solution of ie/ -butyl (l-(hydroxymethyl)cyclobutyl)carbamate (2.43 g, 12.07 mmol) in DCM (5 mL) at 0 C under nitrogen was added dropwise 4 N HCl in dioxane (0.8 mL, 3.0 mmol). The solution was warmed to r.t. and stirred for 1 h, then concentrated to give the title compound as an opaque sticky solid (1.92 g, 91%).

Reference： [1]Patent: WO2016/179550,2016,A1 .Location in patent: Paragraph 0192

8
[ 1142211-17-3 ]
[ 98-59-9 ]
(1-((tert-butoxycarbonyl)amino)cyclobutyl)methyl 4-methylbenzenesulfonate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
57%	With dmap; triethylamine; In dichloromethane; at 0 - 20℃; for 0.12h;Inert atmosphere;	To a stirred solution of tert-butyl (l-(hydroxymethyl)cyclobutyl)carbamate (step 2, 3.7 g, 18.4 mmol) in DCM (40 ml) under N2atmosphere, were added N(Et)3(7.8 ml, 55.2 mmol), followed by TsCl (6 g, 31.3 mmol) and catalytic amount of DMAP at 0 C. The reaction mixture was allowed to stir at room temperature for about 12 hours. After completion of the reaction (monitored by TLC), the reaction mixture was diluted with DCM. The organic layer was washed with saturated NH4C1 solution, brine, dried over anhydrous Na2S04and concentrated under reduced pressure to get the residue. The crude product was purified via silica gel column chromatography with EtOAc and n-Hexane (1 :39) as an eluent to afford the desired compound (3.9 g, yield: 57%) as a white solid. 1H NMR (300 MHz, DMSO-d6): delta 7.76 (d, J = 8.4 Hz, 2H), 7.48 (d, J = 8.4 Hz, 2H), 7.18 (s, 1H), 4.14 (s, 2H), 2.40 (s, 3H), 2.01-1.90 (m, 4H), 1.77-1.68 (m, 2H), 1.30 (s, 9H)

Reference： [1]Patent: WO2017/17630,2017,A1 .Location in patent: Page/Page column 81

9
[ 880166-10-9 ]
[ 1142211-17-3 ]

Yield	Reaction Conditions	Operation in experiment
	With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20℃; for 0.3h;	To a stirred suspension of LiAlH4(1.8 g, 46.4 mmol) in dry THF (15 ml), was slowly added a solution of methyl l-((tert-butoxycarbonyl)amino)cyclobutane-l-carboxylate (step 1, 5.32g, 23.2 mmol) in THF (15 ml) at 0 C. The reaction mixture was brought to room temperature and stirred for about 3 hours. After completion of the reaction (monitored by TLC), the reaction mixture was quenched by the sequential addition of 1.8 mL of H20, 5.4 mL of 15% aq. NaOH and 5.4 mL of H20. The mixture was then poured into EtOAc (100 ml) and stirred for about 30 minutes. The reaction mixture was filtered through celite, dried over Na2S04and concentrated under reduced pressure. The product was isolated by flash column chromatography on silica gel using (EtOAc: hexane-70:30) to give the desired product (3.7 g, yield: 80%) as an oil. 1H NMR (300 MHz, DMSO-d6): delta 6.62 (s, 1H), 4.67 (t, J = 5.4 Hz, 1H), 3.41 (d, J = 5.4 Hz, 2H), 2.22-2.09 (m, 2H), 2.01-1.90 (m, 2H), 1.65-1.57 (m, 2H), 1.36 (s, 9H).

Reference： [1]Patent: WO2017/17630,2017,A1 .Location in patent: Page/Page column 81

10
[ 1142211-17-3 ]
tert-butyl (1-(pyrrolidin-1-ylmethyl)cyclobutyl)carbamate [ No CAS ]

Reference： [1]Patent: WO2017/17630,2017,A1

11
[ 24424-99-5 ]
[ 1142211-17-3 ]

Reference： [1]Patent: WO2017/17630,2017,A1

12
[ 39590-81-3 ]
[ 1142211-17-3 ]

Reference： [1]Chemistry of Heterocyclic Compounds,2017,vol. 53,p. 989 - 996
Khim. Geterotsikl. Soedin.,2017,vol. 53,p. 989 - 996,8
[2]Chemistry of Heterocyclic Compounds,2017,vol. 53,p. 989 - 996
Khim. Geterotsikl. Soedin.,2017,vol. 53,p. 989 - 996,8

13
cyclopropane-1,1-diyldimethanediyl bis(2,2,2-trichloroethanimidoate) [ No CAS ]
[ 1142211-17-3 ]

14
[ 24424-99-5 ]
6-(trichloromethyl)-7-oxa-5-azaspiro[3.4]oct-5-ene [ No CAS ]
[ 1142211-17-3 ]

Yield	Reaction Conditions	Operation in experiment
59%		General procedure: 6 M aqueous HCl (2 ml) was added to asolution of oxazoline 2c (0.158 g, 0.58 mmol) in EtOH(2 ml), and the mixture was stirred for 1 h at roomtemperature, then it was refluxed for 7 h. The solvents wereremoved in vacuo, and saturated aq NaHCO3 solution(10 ml) was added to the residue followed by di-tert-butyldicarbonate (0.275 g, 2.00 mmol) solution in EtOAc(10 ml). The reaction mixture was stirred for 12 h at roomtemprature. The organic phase was separated, and theaquoeus phase was extracted with EtOAc (3 × 10 ml). Thecombined, organic phases were washed with saturated aqNaCl (10 ml) and dried over Na2SO4. The extract wasevaporated and the residue was purified by flash chromatography on silica gel (eluent EtOAc - light petroleum ether,gradient from 1:4 to 1:1).

Reference： [1]Chemistry of Heterocyclic Compounds,2017,vol. 53,p. 989 - 996
Khim. Geterotsikl. Soedin.,2017,vol. 53,p. 989 - 996,8

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P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 1142211-17-3 ] {[proInfo.proName]}

Quality Control of [ 1142211-17-3 ]

Related Doc. of [ 1142211-17-3 ]

Product Details of [ 1142211-17-3 ]

Safety of [ 1142211-17-3 ]

Application In Synthesis of [ 1142211-17-3 ]

[ 1142211-17-3 ] Synthesis Path-Upstream 1~8

[ 1142211-17-3 ] Synthesis Path-Downstream 1~14

Related Functional Groups of [ 1142211-17-3 ]

Aliphatic Cyclic Hydrocarbons

Alcohols

Amides

Amines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 1142211-17-3 ]