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[ CAS No. 114744-50-2 ]

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Chemical Structure| 114744-50-2
Chemical Structure| 114744-50-2
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Product Details of [ 114744-50-2 ]

CAS No. :114744-50-2 MDL No. :MFCD08544260
Formula : C9H10BrN Boiling Point : 299.676°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :212.09 g/mol Pubchem ID :13865046
Synonyms :

Safety of [ 114744-50-2 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H332-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 114744-50-2 ]

  • Upstream synthesis route of [ 114744-50-2 ]
  • Downstream synthetic route of [ 114744-50-2 ]

[ 114744-50-2 ] Synthesis Path-Upstream   1~3

  • 1
  • [ 15115-60-3 ]
  • [ 114744-50-2 ]
YieldReaction ConditionsOperation in experiment
56.6%
Stage #1: With hydroxylamine hydrochloride In methanol for 1 h; Reflux
Stage #2: With diisobutylaluminium hydride In dichloromethane; toluene at 0 - 20℃;
Compound e (1.05 g, 5 mmol) was dissolved in methanol (14 ml) and hydroxylamine hydrochloride (1.4 g, 20 mmol) was added and refluxed for 1 h.Concentrate in vacuo, add dichloromethane and 50percent NaHCO3 for 20 minutes, dry the organic layer and concentrate to a white solid. Yield: 99percent.The resulting white solid (5 mmol) was dissolved in methylene chloride (30 ml), cooled to 0 °C, AlH (Bu-i) 2 (20 ml, 30 mmol, 1.5 M in toluene) was slowly added, and the mixture was stirred for 30 min.Move to room temperature and stir overnight. Quenching with water under ice bath conditions, dichloromethane extraction, saturated brine,After drying over anhydrous sodium sulfate, it was concentrated and purified by silica gel column (PE:EA=3:1) to give 600 mg of pale yellow solid f, yield: 56.6percent.
Reference: [1] Patent: CN107814785, 2018, A, . Location in patent: Paragraph 0062; 0081; 0082; 0083
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  • [ 4964-71-0 ]
  • [ 114744-50-2 ]
Reference: [1] Organic Letters, 2018, vol. 20, # 4, p. 1171 - 1174
[2] Angewandte Chemie - International Edition, 2018, vol. 57, # 31, p. 9950 - 9954[3] Angew. Chem., 2018, vol. 130, p. 10098 - 10102,5
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  • [ 903557-27-7 ]
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Reference: [1] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 17, p. 7956 - 7967
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