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Chemical Structure| 114744-83-1 Chemical Structure| 114744-83-1

Structure of 114744-83-1

Chemical Structure| 114744-83-1

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Product Details of [ 114744-83-1 ]

CAS No. :114744-83-1
Formula : C13H18N2O4
M.W : 266.29
SMILES Code : C(OC(N[C@H](C(N(OC)C)=O)C)=O)C1=CC=CC=C1
MDL No. :MFCD10698127

Safety of [ 114744-83-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H319
Precautionary Statements:P264-P270-P280-P301+P312+P330-P305+P351+P338-P337+P313-P501

Application In Synthesis of [ 114744-83-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 114744-83-1 ]

[ 114744-83-1 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 50638-47-6 ]
  • [ 114744-83-1 ]
  • [ 1432055-41-8 ]
YieldReaction ConditionsOperation in experiment
0.82 g With TurboGrignard; In tetrahydrofuran; at -20 - 20℃;Inert atmosphere; Step 1. A solution of <strong>[50638-47-6]4-bromo-2-chloroanisole</strong> (3 g, 13.55 mmol) and (S)-benzyl (1-(methoxy(methyl)amino)-1-oxopropan-2-yl)carbamate (3.79 g, 14.22 mmol) in THF (33.9 mL) was cooled to -20 C. with dry ice/acetone. To this solution was added isopropylmagnesium chloride lithium chloride complex (22.9 mL, 29.8 mmol) at -20 C. dropwise under N2. After addition, the reaction mixture was warmed up to rt and stirred overnight. The reaction mixture was cooled to -40 C. and slowly poured into a stirred mixture of crushed ice and 30 mL of 1N HCl. The resulting mixture was diluted with 30 mL of brine, extracted with EtOAc (3*50 mL). The organic layer was dried with Na2SO4 and concentrated. The residue was purified by silica gel chromatography, eluted with 0-100% EtOAc in hexane to give (S)-benzyl (1-(3-chloro-4-methoxyphenyl)-1-oxopropan-2-yl)carbamate (0.82 g) as a white solid. 1H NMR (500 MHz, CDCl3): delta 8.05 (s, 1H), 7.92 (d, 1H), 6.98 (d, 1H), 5.93 (d, 1H), 5.29 (m, 1H), 5.16 (s, 2H), 3.99 (s, 3H), 1.43 (d, 3H).
  • 2
  • [ 50638-47-6 ]
  • [ 114744-83-1 ]
  • [ 1432055-42-9 ]
  • 3
  • [ 114744-83-1 ]
  • [ 175205-81-9 ]
  • C17H15F3N2O3 [ No CAS ]
  • 4
  • [ 130723-13-6 ]
  • [ 114744-83-1 ]
  • C18H15F4NO3 [ No CAS ]
 

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