Alternatived Products of [ 1147894-98-1 ]
Product Details of [ 1147894-98-1 ]
CAS No. : | 1147894-98-1 |
MDL No. : | MFCD12405367 |
Formula : |
C14H20BFO2
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
250.12
|
Pubchem ID : | - |
Synonyms : |
|
Safety of [ 1147894-98-1 ]
Application In Synthesis of [ 1147894-98-1 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Upstream synthesis route of [ 1147894-98-1 ]
- Downstream synthetic route of [ 1147894-98-1 ]
- 1
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[ 557-21-1 ]
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[ 1147894-98-1 ]
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[ 867367-02-0 ]
- 2
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[ 443-88-9 ]
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[ 73183-34-3 ]
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[ 1147894-98-1 ]
- 3
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[ 2148-57-4 ]
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[ 1147894-98-1 ]
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[ 96042-30-7 ]
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7-chloro-4-(4-fluoro-3,5-dimethylphenyl)quinazoline
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
71% |
With sodium carbonate; In 1,2-dimethoxyethane; water; ethyl acetate; |
Synthesis of 7-chloro-4-(4-fluoro-3,5-dimethylphenyl)quinazoline <strong>[2148-57-4]4,7-dichloroquinazoline</strong> (4.0 g, 20.1 mmol), 2-(4-fluoro-3,5-dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (5.53 g, 22.1 mmol), sodium carbonate (5.33 g, 50.2 mmol), palladium tetrakis (0.70 g, 0.60 mmol), dimethoxyethane ("DME") (160 mt), and water (40 mL) were combined in a three neck round bottom flask. A condenser was attached then the system was evacuated and purged with nitrogen three times. The reaction was heated to a vigorous reflux overnight. The reaction was diluted with ethyl acetate, water and brine. The aqueous was partitioned off and the organic was washed once with brine, dried with sodium sulfate, filtered then concentrated down to a yellow solid. The yellow solid was purified with silica gel using DCM to 85/15 DCM/ethyl acetate solvent system to get 4.1 g of light yellow solid for a 71% yield. |
- 4
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[ 2148-57-4 ]
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[ 1147894-98-1 ]
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7-chloro-4-(4-fluoro-3,5-dimethylphenyl)quinazoline
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
71% |
With sodium carbonate; In 1,2-dimethoxyethane; water;Reflux; Inert atmosphere; |
The <strong>[2148-57-4]4,7-dichloro-quinazoline</strong> (4.0g, 20.1mmol), 2- (4- fluoro-3,5-dimethylphenyl) -4,4,5,5-tetramethyl-1,3 , 2-dioxaborolane (5.53g, 22.1mmol), sodium carbonate (5.33g, 50.2mmol), Pd tetrakis (0.70g, 0.60mmol), dimethoxyethane ( "DME") (160mL) combined with water (40 mL) in a three-necked round bottom flask. Then connected to the condenser, the system is evacuated and purged three times with nitrogen. The reaction was heated to vigorous reflux overnight. With ethyl acetate, water and brine, the reaction was diluted. Allocation aqueous organics were washed with brine once and dried over sodium sulfate, filtered, then concentrated to a yellow solid. The yellow solid with DCM to 85 / 15DCM / ethyl acetate solvent system of pure silica gelTechnology, to give a pale yellow solid 4.1g, 71% yield. |
- 5
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[ 1147894-98-1 ]
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[ 2915-16-4 ]
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C24H19FN2
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
92% |
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In ethanol; water; toluene; at 80℃; for 20h;Inert atmosphere; |
2-Chloro-4,6-phenylpyrimidine 666.83 mg (2.5 mmol) and a intermediate 750.36 mg (3 mmol) were added to a 250 mL three-necked flask under N2 atmosphere, and dissolved in 90 mL of toluene and 30 mL of ethanol. Then, 30 mL of a 2 mol/L potassium carbonate aqueous solution and 231.2 mg (0.2 mmol) of a catalyst tetrakistriphenylphosphine palladium were placed, and the mixture was heated to 80 C and refluxed for 20 hours. After the end of the reaction, the system was cooled to room temperature, and toluene and ethanol were removed by rotary evaporation, extracted with dichloromethane DCM and water, and the organic phase was taken and evaporated to remove excess DCM.Column chromatography on silica gel gave 815 mg of Intermediate C with a yield of 92%. |
- 6
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[ 3740-92-9 ]
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[ 1147894-98-1 ]
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C26H22F2N2
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
90% |
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In ethanol; water; toluene; at 80℃; for 20h;Inert atmosphere; |
<strong>[3740-92-9]4,6-dichloro-2-phenylpyrimidine</strong> 562.68 mg (2.5 mmol) and a intermediate 1.38 g (5.5 mmol) were added to a 250 mL three-necked flask under N2 atmosphere, using 90 mL of toluene and 30 mL of ethanol. After dissolving, 30 mL of a 2 mol/L potassium carbonate aqueous solution and 231.2 mg (0.2 mmol) of a catalyst tetrakistriphenylphosphine palladium were added, and the mixture was heated to reflux at 80 ° C for 20 hours. After the completion of the reaction, the system was cooled to room temperature, and toluene and ethanol were removed by rotary evaporation, and extracted with dichloromethane, DCM and water, and the organic phase was taken out, and the excess DCM was evaporated to afford 901 mg of Intermediate A. The yield is 90percent. |