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[ CAS No. 1150164-80-9 ]

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Chemical Structure| 1150164-80-9
Chemical Structure| 1150164-80-9
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Product Details of [ 1150164-80-9 ]

CAS No. :1150164-80-9 MDL No. :MFCD12026027
Formula : C11H12F2O3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :230.21 g/mol Pubchem ID :46739353
Synonyms :

Safety of [ 1150164-80-9 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1150164-80-9 ]

  • Upstream synthesis route of [ 1150164-80-9 ]
  • Downstream synthetic route of [ 1150164-80-9 ]

[ 1150164-80-9 ] Synthesis Path-Upstream   1~4

  • 1
  • [ 529-28-2 ]
  • [ 667-27-6 ]
  • [ 1150164-80-9 ]
YieldReaction ConditionsOperation in experiment
96% With copper In dimethyl sulfoxide at 60℃; for 12 h; Inert atmosphere General procedure: To a suspension of activated Cu powder (2.6 eq.) in DMSO (0.38 M) was added the appropriate aryl iodide (1.0 eq.) and ethyl bromodifluoroacetate (1.0 eq.) or ethyl bromofluoroacetate (1.0 eq.) under nitrogen atmosphere. The reaction mixture was stirred at 60°C for 12 h. The reaction mixture was filtered through a pad of Celite® and washed with Et2O. The mixture was washed with aq. NH4Cl (sat., 2x) and brine (2x), then dried over MgSO4, filtered and concentrated in vacuo. The crude product was purified by silica gel column chromatography.
Reference: [1] Synlett, 2016, vol. 27, # 1, p. 25 - 28
[2] Organic Letters, 2013, vol. 15, # 11, p. 2648 - 2651
[3] European Journal of Organic Chemistry, 2016, vol. 2016, # 33, p. 5529 - 5538
[4] European Journal of Organic Chemistry, 2017, vol. 2017, # 40, p. 6052 - 6059
  • 2
  • [ 667-27-6 ]
  • [ 100-66-3 ]
  • [ 915133-57-2 ]
  • [ 1150164-80-9 ]
  • [ 112545-98-9 ]
Reference: [1] European Journal of Organic Chemistry, 2015, vol. 2015, # 8, p. 1719 - 1726
[2] Advanced Synthesis and Catalysis, 2014, vol. 356, # 13, p. 2741 - 2748
  • 3
  • [ 100-66-3 ]
  • [ 205865-67-4 ]
  • [ 915133-57-2 ]
  • [ 1150164-80-9 ]
  • [ 112545-98-9 ]
Reference: [1] European Journal of Organic Chemistry, 2016, vol. 2016, # 28, p. 4916 - 4921
  • 4
  • [ 90-04-0 ]
  • [ 1150164-80-9 ]
Reference: [1] European Journal of Organic Chemistry, 2016, vol. 2016, # 33, p. 5529 - 5538
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