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Chemical Structure| 115078-43-8 Chemical Structure| 115078-43-8

Structure of 115078-43-8

Chemical Structure| 115078-43-8

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Product Details of [ 115078-43-8 ]

CAS No. :115078-43-8
Formula : C14H16N4
M.W : 240.30
SMILES Code : C1(CNCC2=CC=CC(CNC3)=N2)=NC3=CC=C1
MDL No. :N/A

Safety of [ 115078-43-8 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H314
Precautionary Statements:P273-P260-P270-P264-P280-P303+P361+P353-P301+P330+P331-P363-P301+P312+P330-P304+P340+P310-P305+P351+P338+P310-P405
Class:8
UN#:3263
Packing Group:

Application In Synthesis of [ 115078-43-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 115078-43-8 ]

[ 115078-43-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 40299-87-4 ]
  • [ 115078-43-8 ]
  • C26H34N6O4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
43% With potassium carbonate; In acetonitrile; for 24h;Inert atmosphere; Reflux; The commercially available 4-(bromoacetyl)morpholine (0.22 g, 1.06 mmol, 2.5 equivalent) was dissolved in dry acetonitrile (5 ml), then added dropwise to the acetonitrile suspension (30 ml) of 2,l l-diaza[3.3](2,6)-pyridinophane (0.10 g, 0.42 mmol, 1 equivalent) and K2C03 (0.17 g, 1.26 mmol, 3 equivalent) at room temperature within 30 minutes. Then the reaction mixture was refluxed in N2 atmosphere for 24 hours. After 24 hours, K2C03 was filtered from the hot solution, and the solvent was evaporated at reduced pressure. The obtained crude product was purified with HPLC (Luna lOu-Prep CI 8(2) 100A (250 21.20 mm; 10 mueta ) column), ACN:H20/TFA was applied as eluent [ACN: acetonitrile; TFA: trifluoroacetic acid]. TFA was contained only in water in 0.005 M concentration. Yield: 0.09 (43 %). (0038) FontWeight="Bold" FontSize="10" H NMR [360 MHz, D20] delta 3.35 (4H, s, (2pcs CH2)), 3.51 -3.71 (16H, m, (8pcs CH2)), 4.33 (8H, br, (4pcs CH2)), 7.18 (4H, d, (4pcs CH) aromatic), 7.74 (2H, t, (2 pes CH) aromatic); 13C NMR [100 MHz, D20] delta 45.5 (4pcs CH2); 56.1 (2pcs CH2); 59.9 (4pcs CH2); 69.1 (4pcs CH2); 123.7 (4pcs CH aromatic); 133.4 (2pcs CH aromatic); 150.2 (4pcs C aromatic); 166.1 (2pcs C(=0)
 

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