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Chemical Structure| 1154276-93-3 Chemical Structure| 1154276-93-3

Structure of 1154276-93-3

Chemical Structure| 1154276-93-3

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Product Details of [ 1154276-93-3 ]

CAS No. :1154276-93-3
Formula : C9H15N3O2S
M.W : 229.30
SMILES Code : O=S(=O)(NC)C1C=C(N)C(N(C)C)=CC=1
MDL No. :MFCD12173039

Safety of [ 1154276-93-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H332
Precautionary Statements:P280

Application In Synthesis of [ 1154276-93-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1154276-93-3 ]

[ 1154276-93-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1154276-93-3 ]
  • [ 13790-39-1 ]
  • 3-[6,7-bis(methyloxy)-4-quinazolinyl]amino}-4-(dimethylamino)-N-methylbenzenesulfonamide hydrochloride [ No CAS ]
YieldReaction ConditionsOperation in experiment
35% With hydrogenchloride; In isopropyl alcohol; at 150℃; under 4500.45 Torr; for 0.25h;Microwave irradiation; EXAMPLE 1 3-[6J-bis(methyloxy)-4-quinazolinyl]amino}-4-(dimethylmethylbenzenesulfonamide hydrochloride•2 HClTo a mixture of 3-amino-4-(dimethylamino)-//-methylbenzenesulfonamide (0.1 OOg, 0.434mmol) and 4-chloro-6,7-bis(methyloxy)quinazoline (0.075 g, 0.334 mmol) in isopropanol (2 ml.) was added HCl (0.334 ml_, 0.334 mmol). The resulting mixture was then subjected to microwave irradiation (150 C, 6 bar) for 15 minutes. The mixture was then concentrated and purified via column chromatography (5-10% MeOH/Ch^C ) to give an orange solid that was triturated with EtOAc and dried to afford 3-[6,7-bis(methyloxy)-4- quinazolinyl]amino}-4-(dimethylamino)-//-methylbenzenesulfonamide (54 mg, 35% yield) as orange crystals.
 

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