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Chemical Structure| 115551-40-1 Chemical Structure| 115551-40-1

Structure of 115551-40-1

Chemical Structure| 115551-40-1

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Product Details of [ 115551-40-1 ]

CAS No. :115551-40-1
Formula : C11H8F2N2O4
M.W : 270.19
SMILES Code : O=C(C1=CN(NC)C2=C(C=C(F)C(F)=C2O)C1=O)O
MDL No. :MFCD31691171

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Application In Synthesis of [ 115551-40-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 115551-40-1 ]

[ 115551-40-1 ] Synthesis Path-Downstream   1~1

  • 1
  • pyridinium p-toluenesufonate [ No CAS ]
  • [ 115551-40-1 ]
  • [ 621-63-6 ]
  • 9,10-difluoro-2-(hydroxymethyl)-3-methyl-7-oxo-2,3-dihydro7H-pyrido[3,2,1-ij]-1,3,4-benzoxadiazine-6-carboxylic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
In 1,4-dioxane; EXAMPLE 3 Preparation of 9,10-difluoro-2-(hydroxymethyl)-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[3,2,1-ij]-1,3,4-benzoxadiazine-6-carboxylic acid A suspension of 6,7-difluoro-8-hydroxy-1-(methylamino)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid (50 mg) obtained in Reference example (i). glycolaldehyde diethylacetal (45 mul) and pyridinium p-toluenesufonate (7 mg) in dry dioxane (2 ml) was heated at 110° C. for 5 hours under nitrogen atmosphere. After the solvent was removed under reduced pressure, the crystalline residue was washed with water and methanol to give 52 mg of 9,10-difluoro-2-(hydroxymethyl)- 3-methyl-7-oxo-2,3-dihydro-7H-pyrido[3,2,1-ij]-1,3,4- benzoxadiazine-6-carboxylic acid, mp 254°-258° C. (dec.); MS m/z 312 (M+).
 

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