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Chemical Structure| 115970-17-7 Chemical Structure| 115970-17-7

Structure of 115970-17-7

Chemical Structure| 115970-17-7

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Product Details of [ 115970-17-7 ]

CAS No. :115970-17-7
Formula : C9H11ClN4
M.W : 210.66
SMILES Code : NC1=NCCN1CC2=CC=C(Cl)N=C2

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Application In Synthesis of [ 115970-17-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 115970-17-7 ]

[ 115970-17-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 6914-79-0 ]
  • [ 115970-17-7 ]
  • C14H14ClN5O [ No CAS ]
YieldReaction ConditionsOperation in experiment
Example 1: Compound 1-2 (compound of formula I, wherein R1 and R2 are H; Het is 6-chloropyridyl; -W1-W2-W3-W4- is -NH-CH2-CH2-; X1 is 0; X2 is CN; and R3 and R5together with the carbon atom to which they are attached form a cyclopropyl ring and m is0) To the amine compound El (14.2 mmol) in dichloromethane (20 mL) was added triethylamine (57.3 mmol) and 1-cyanocyclopropanecarboxylic acid (18.9 mmol) at 000, and the mixture was stirred at room temperature for 5 mm, before a solution of propylphosphonicanhydride (22.7 mmol, 50percent by weight solution in ethyl acetate) was added. The mixture was allowed to reach room temperature over night. The reaction was then diluted with ethyl acetate (200 mL), washed with saturated aqueous NaHCO3 (200 mL) and water (200mL). The layers were separated, and the organic layer dried over Na2SO4 and concentrated in vacuoto afford a residue, which was purified using column chromatography over silica gel (0?*30percentMeOH/EtOAc), followed by preparative HPLC to give the title compound.1HNMR (ODd3, 400 MHz): 1.49 (m, 2H), 1.58 (m, 2H), 3.44 (m, 2H), 3.65 (m, 2H), 4.612H), 7.35 (d, 1 H), 7.83 (m, 1 H), 8.27 (s, 1 H), 8.38 (s, 1 H) ppm.
 

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