1160066-14-7| 2,4-Dichloro-N,N-dimethylpyrimidine-5-carboxamide| Ambeed

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CAS No. :	1160066-14-7
Formula :	C₇H₇Cl₂N₃O
M.W :	220.06
SMILES Code :	O=C(N(C)C)C1C(Cl)=NC(Cl)=NC=1

Yield	Reaction Conditions	Operation in experiment
100%	With triethylamine; In dichloromethane; at 0 - 20℃;	Example 59: Synthesis of 2,4-dichloro-pyrimidine-5-carboxylic acid dimethylamide; To a solution of 2,4-dichloro-pyrimidine-5-carbonyl chloride (197.7 mg, 0.94 mmol) in CH2CI2 (9.4 mL) at RT is added Me2NH (2.0 /W THF solution, 390 μl_, 0.78 mmol) and Et3N (108.6 μl_, 0.78 mmol) at 0 0C. The reaction mixture is stirred overnight at RT. After adding water, the mixture is extracted with CH2CI2. The organic layer is dried and concentration under reduce pressure give 2,4-dichloro-pyrimidine-5-carboxylic acid dimethylamide (272.5 mg, quant). ESI-MS m/z: 221 [M+1]+, Retantion time 1.94 min (condition B).
77%	With triethylamine; In dichloromethane; at 0 - 25℃; for 3h;	<strong>[2972-52-3]2,4-dichloropyrimidine-5-carbonyl chloride</strong> (1.0 eq.) Was added to CH2Cl2 (0.1 M) to dissolve, dimethylamine (0.8 eq.) And TEA (0.8 eq.) Were added at 0 oC, and then at room temperature. Was reacted for 3 hours. Water was poured into the reaction mixture, followed by extraction with CH2Cl2. (X3) The collected organic layer was removed with MgSO4. After filtration, it was concentrated and the compound was purified by MPLC (EtOAc: Hex). After concentration, the desired compound was obtained as a light yellow liquid. (Yield: 77%)

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Physical hazards
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H200	Unstable explosive
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H202	Explosive; severe projection hazard
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H250	Catches fire spontaneously if exposed to air
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H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
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Health hazards
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H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 1160066-14-7

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CAS No.: 1160066-14-7

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