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Chemical Structure| 116008-78-7 Chemical Structure| 116008-78-7

Structure of 116008-78-7

Chemical Structure| 116008-78-7

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Product Details of [ 116008-78-7 ]

CAS No. :116008-78-7
Formula : C5H7ClN2OS
M.W : 178.64
SMILES Code : CC(=O)C1N=C(N)SC=1.[H]Cl
MDL No. :N/A

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Application In Synthesis of [ 116008-78-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 116008-78-7 ]

[ 116008-78-7 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 116008-78-7 ]
  • [ 101258-16-6 ]
YieldReaction ConditionsOperation in experiment
57% With ammonium hydroxide In water at 0℃; for 0.25 h; (1c)
1-(2-Amino-thiazol-4-yl)-ethanone hydrochloride (5.6 g 29.1 mmol) was dissolved in water (15 mL) and cooled in an ice bath.
To this was added dropwise 17 N ammonium hydroxide (15 mL, 105 mmol).
The resulting mixture was stirred for 15 minutes than filtered and washed with cold water (3*), cold methanol (3*50 mL), ethyl ether (3*10 mL).
The precipitate was dried first by passing air through the material and then in vacuo to give 1-(2-amino-thiazol-4-yl)-ethanone as a pale yellow solid (2.6 g, 57percent).
References: [1] Patent: US2006/41146, 2006, A1, . Location in patent: Page/Page column 10.
 

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