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Chemical Structure| 1160270-01-8 Chemical Structure| 1160270-01-8

Structure of 1160270-01-8

Chemical Structure| 1160270-01-8

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Product Details of [ 1160270-01-8 ]

CAS No. :1160270-01-8
Formula : C21H14F6O5S
M.W : 492.39
SMILES Code : O=C(OCC)C1=CC(OS(=O)(C(F)(F)F)=O)=C2C=CC(C3=CC=C(C(F)(F)F)C=C3)=CC2=C1

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Application In Synthesis of [ 1160270-01-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1160270-01-8 ]

[ 1160270-01-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1016641-70-5 ]
  • [ 1160270-01-8 ]
  • [ 1160270-24-5 ]
YieldReaction ConditionsOperation in experiment
With sodium carbonate;dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; In water; N,N-dimethyl-formamide; at 85℃; for 4.0h; A suspension of ethyl 7-[4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfonyl]oxy}-2-naphthoate (320 mg, 0.65 mmol) from Example 1, Step 2, the boronate from Step 1 (190 mg, 0.715 mmol), DMF (8 mL) and Na2CO3 (0.975 niL, 1.950 mmol) was degassed. PdCl2(dppf)-CH2Cl2 adduct (53.1 mg, 0.065 mmol) was added and the mixture was heated at 85 0C for 4 h. It was cooled and poured into dilute aqueous NH4Cl. The mixture was extracted twice with EA and the combined organic layers were dried in the ususal manner. The residue from evaporation was passed through a short pad Of SiO2 eluting with 2:1 EA:Hexanes to give ethyl 4-[4-(methylsulfmyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-2- naphthoate. lH NMR (500 MHz, acetone-d6): δ 8.85 (IH, s), 8.65 (IH, s), 8.15 (2H, d), 8.0-8.1 (3H, m), 7.9-8.0 (4H, m), 7.8 (2H, d), 4.45-4.5 (2H, q), 2.85 (3H, s), 1.45 (3H, t) ppm.
 

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