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[ CAS No. 116041-19-1 ]

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Chemical Structure| 116041-19-1
Chemical Structure| 116041-19-1
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Product Details of [ 116041-19-1 ]

CAS No. :116041-19-1 MDL No. :MFCD00173111
Formula : C12H14N2O2 Boiling Point : -
Linear Structure Formula :- InChI Key :N/A
M.W :218.25 g/mol Pubchem ID :-
Synonyms :

Safety of [ 116041-19-1 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 116041-19-1 ]

  • Downstream synthetic route of [ 116041-19-1 ]

[ 116041-19-1 ] Synthesis Path-Downstream   1~5

YieldReaction ConditionsOperation in experiment
Dimethylitaconat, entspr. Amin, NH3;
  • 2
  • [ 51535-00-3 ]
  • [ 116041-19-1 ]
YieldReaction ConditionsOperation in experiment
With ammonia; In methanol; Step 1 Methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate (50 g, 0.21 mol) was stirred in a solution of ammonia in methanol (7 M, 400 mL, 2.8 mol). After 2 days, the solution was concentrated with heating (50 C.) to about 300 mL at which point all solids remained dissolved. The reaction was then allowed to cool down and the resulting solid was filtered, washed with ether and dried to give 1-benzyl-5-oxo-pyrrolidine-3-carboxylic acid amide as colorless crystals (40 g).
  • 3
  • [ 116041-19-1 ]
  • [ 368429-69-0 ]
YieldReaction ConditionsOperation in experiment
75% With [bis(acetoxy)iodo]benzene In water; acetonitrile at 20℃; for 1h;
  • 4
  • [ 116041-19-1 ]
  • [ 18471-40-4 ]
  • 5
  • [ 116041-19-1 ]
  • [ 7757-82-6 ]
  • [ 93138-61-5 ]
YieldReaction ConditionsOperation in experiment
In tetrahydrofuran 4.2 Step 2 Step 2 1-Benzyl-5-oxo-pyrrolidine-3-carboxylic acid amide (22 g, 0.1 mol) was added portionwise to a stirred solution of lithium aluminum hydride (9.5 g, 0.25 mol, 2.5 equiv.) in dry tetrahydrofuran (600 mL). After the initial effervescence had subsided, the reaction mixture was heated at reflux at room temperature for 24 h, at which time analysis of the reaction mixture by LCMS showed there was no starting material. The reaction mixture was quenched by dropwise addition of saturated sodium sulphate solution with stirring until no further effervescence was observed. The suspension was filtered through a celite plug, eluding with diethyl ether (200 mL). The solvent was remove to afford 3-(RS)-aminomethyl-1-benzylpyrrolidine as an oil (14.7 g) which was used directly without further purification.
Historical Records

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