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[ CAS No. 116460-89-0 ] {[proInfo.proName]}

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Chemical Structure| 116460-89-0
Chemical Structure| 116460-89-0
Structure of 116460-89-0 * Storage: {[proInfo.prStorage]}
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Product Details of [ 116460-89-0 ]

CAS No. :116460-89-0 MDL No. :MFCD08234822
Formula : C12H13NO2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 203.24 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 116460-89-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

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[ 116460-89-0 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 116460-89-0 ]
  • [ 42287-94-5 ]
Reference: [1] Patent: US6235731, 2001, B1,
  • 2
  • [ 116460-89-0 ]
  • [ 83101-12-6 ]
YieldReaction ConditionsOperation in experiment
42%
Stage #1: With methanol; lithium borohydride In diethyl ether for 3 h; Heating / reflux
Stage #2: With ammonium chloride In diethyl ether; water
To a solution of LiBH4 (14 g, 0.65 mol) in dry ether (400 mL) was added 3- (4-cyanophenyl) propionic acid ethyl ester (50 g, 0.249 mol; see step (ii) above), followed by methanol (27 mL) dropwise. The reaction mixture was refluxed for 3h. After completion (monitored by TLC), the reaction was quenched by adding cold, saturated ammonium chloride solution (100 mL), followed by water (300 mL). The layers were then separated. The aqueous layer was extracted with ether (2 x 100 mL) and the combined organic layers were washed with brine. After drying over anhydrous sodium sulfate, the organic layer was concentrated to give the crude product. This crude product was purified by column chromatography over silica gel, using ethyl acetate in petroleum ether as eluent. This yielded 16.5 g (42percent) of the sub- title compound as a pale yellow liquid.
Reference: [1] Patent: WO2005/123747, 2005, A1, . Location in patent: Page/Page column 53
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