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[ CAS No. 1166756-72-4 ] {[proInfo.proName]}

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3d Animation Molecule Structure of 1166756-72-4
Chemical Structure| 1166756-72-4
Chemical Structure| 1166756-72-4
Structure of 1166756-72-4 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1166756-72-4 ]

CAS No. :1166756-72-4 MDL No. :MFCD12198860
Formula : C7H7BrClN Boiling Point : -
Linear Structure Formula :- InChI Key :BGECTFQDFFAMKV-UHFFFAOYSA-N
M.W : 220.49 Pubchem ID :53429593
Synonyms :

Safety of [ 1166756-72-4 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P301+P312+P330 UN#:N/A
Hazard Statements:H302 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1166756-72-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1166756-72-4 ]

[ 1166756-72-4 ] Synthesis Path-Downstream   1~9

  • 1
  • [ 885518-95-6 ]
  • [ 1166756-72-4 ]
YieldReaction ConditionsOperation in experiment
Step 1. Preparation of 3-bromo-5-chloro-2-methylaniline This material was prepared from <strong>[885518-95-6]1-bromo-5-chloro-2-methyl-3-nitrobenzene</strong> following the procedure used for SM-9, step 3 (96%): LCMS(m/z): 219.9 (MH+); tR=0.99 minute.
  • 2
  • [ 1166756-72-4 ]
  • [ 98769-85-8 ]
  • 10-bromo-8-chloro-11-methyl-6-phenyl-6H-chromeno[4,3-b]quinoline [ No CAS ]
YieldReaction ConditionsOperation in experiment
82% With silica gel supported sodium hydrogen sulfate In ethanol at 20℃; for 0.5h; Irradiation; 2.2.4. General Procedure for the Synthesis of 6-phenyl-6Hchromeno[4, 3-b] Quinolines (7a-o) General procedure: To a mixture of aldehyde (5) (1.0 mmol) and aniline (6) (1.0 mmol) in ethanol (5 mL) solvent, the catalysts sodium bisulfate embedded silica [37] (5.0 mmol) was added. The whole reaction mixture was stirred at room temperature for 30 min under halo photochemical light of wavelength 15000-18000 cm-1. The reaction completion monitored by the Thin Layer Chromatography (TLC). The solvent removed under reduced pressure from the crude product. Later, sodium bicarbonate solution (10 mL) added to the crude mixture and extracted with ethyl acetate (3x10 mL). From the collected organic layer, the solvent removed under reduced pressure. The resulting crude mixture was purified by the silica gel column using ethyl acetate/n-hexane (2:1) mixture to get 6-phenyl-6H-chromeno [4, 3-b] quinolines (7a) in good yield.
  • 3
  • [ 219312-44-4 ]
  • [ 1166756-72-4 ]
YieldReaction ConditionsOperation in experiment
With hydrogen bromide; copper(I) bromide; sodium nitrite In water at 0 - 80℃; for 2.5h;
  • 4
  • [ 1166756-72-4 ]
  • C17H23BrClNO3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sulfuric acid; sodium nitrite / water / 2 h / 0 - 100 °C 2: potassium carbonate / N,N-dimethyl-formamide / 90 °C
  • 5
  • [ 1166756-72-4 ]
  • C24H30ClN3O4S [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: sulfuric acid; sodium nitrite / water / 2 h / 0 - 100 °C 2: potassium carbonate / N,N-dimethyl-formamide / 90 °C 3: tris-(dibenzylideneacetone)dipalladium(0); t-BuBrettPhos; potassium carbonate; acetic acid / <i>tert</i>-butyl alcohol / 110 °C / Inert atmosphere; Sealed tube
  • 6
  • [ 1166756-72-4 ]
  • (S)-6,6-dimethyl-2-phenyl-4,5,6,7-tetrahydrobenzo[d]oxazol-4-ol [ No CAS ]
  • C24H26ClF6N3O3S [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1.1: sulfuric acid; sodium nitrite / water / 2 h / 0 - 100 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 90 °C 3.1: tris-(dibenzylideneacetone)dipalladium(0); t-BuBrettPhos; potassium carbonate; acetic acid / <i>tert</i>-butyl alcohol / 110 °C / Inert atmosphere; Sealed tube 4.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 0 °C 4.2: 24 h / 20 °C 5.1: sodium tetrahydroborate / methanol / 20 °C 6.1: 2,2'-iminobis[ethanol]; acetic acid / hexane; ethanol / 35 °C
  • 7
  • [ 1166756-72-4 ]
  • 2-methyl-3-bromo-5-chlorophenol [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sulfuric acid; sodium nitrite In water at 0 - 100℃; for 2h;
  • 8
  • [ 1166756-72-4 ]
  • 2-((5-chloro-2-methyl-3-((1-(4,4,4-trifluoro-3-(trifluoromethyl)-butanoyl)piperidin-4-yl)oxy)phenyl)amino)-6,7-dihydrobenzo[d]-thiazol-4(5H)-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: sulfuric acid; sodium nitrite / water / 2 h / 0 - 100 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 90 °C 3.1: tris-(dibenzylideneacetone)dipalladium(0); t-BuBrettPhos; potassium carbonate; acetic acid / <i>tert</i>-butyl alcohol / 110 °C / Inert atmosphere; Sealed tube 4.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 0 °C 4.2: 24 h / 20 °C
  • 9
  • [ 1166756-72-4 ]
  • 1-(4-(5-chloro-3-((4-hydroxy-4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)amino)-2-methylphenoxy)piperidin-1-yl)-4,4,4-trifluoro-3-(trifluoromethyl)butan-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1.1: sulfuric acid; sodium nitrite / water / 2 h / 0 - 100 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 90 °C 3.1: tris-(dibenzylideneacetone)dipalladium(0); t-BuBrettPhos; potassium carbonate; acetic acid / <i>tert</i>-butyl alcohol / 110 °C / Inert atmosphere; Sealed tube 4.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 0 °C 4.2: 24 h / 20 °C 5.1: sodium tetrahydroborate / methanol / 20 °C
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