Name: 117-99-7|(2-Hydroxyphenyl)(phenyl)methanone|95%
Brand: Ambeed
SKU: A203845
Price: 14.0 USD
Availability: InStock
Rating: 99 (28 reviews)

1
[ 109-65-9 ]
[ 117-99-7 ]
[ 810672-90-3 ]

Yield	Reaction Conditions	Operation in experiment
82%	With caesium carbonate In acetonitrile at 50℃;
82%	With caesium carbonate In acetonitrile at 50℃; Inert atmosphere;
	With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 12h;

Reference： [1]Soldi, Cristian; Lamb, Kellan N.; Squitieri, Richard A.; Gonzlez-Lpez, Marcos; Di Maso, Michael J.; Shaw, Jared T. [Journal of the American Chemical Society, 2014, vol. 136, # 43, p. 15142 - 15145]
[2]Lamb, Kellan N.; Squitieri, Richard A.; Chintala, Srinivasa R.; Kwong, Ada J.; Balmond, Edward I.; Soldi, Cristian; Dmitrenko, Olga; Castiñeira Reis, Marta; Chung, Ryan; Addison, J. Bennett; Fettinger, James C.; Hein, Jason E.; Tantillo, Dean J.; Fox, Joseph M.; Shaw, Jared T. [Chemistry - A European Journal, 2017, vol. 23, # 49, p. 11843 - 11855]
[3]Bonnard; Meyer-Oulif [Bulletin de la Societe Chimique de France, 1931, vol. <4>49, p. 1303,1305,1306]
[4]Liu, Wenbo; Chen, Ning; Yang, Xiaobo; Li, Lu; Li, Chao-Jun [Chemical Communications, 2016, vol. 52, # 89, p. 13120 - 13123]

2
[ 85-19-8 ]
[ 117-99-7 ]

Reference： [1]Patent: US2590813,1949,

3
[ 119-61-9 ]
[ 117-99-7 ]

Yield	Reaction Conditions	Operation in experiment
81%	With palladium diacetate; bis-[(trifluoroacetoxy)iodo]benzene In 1,2-dichloro-ethane at 80℃; for 2h;
80%	With palladium diacetate; Selectfluor; trifluoroacetic acid; trifluoroacetic anhydride at 100℃; for 3.5h; Sealed tube; regioselective reaction;
62%	With dirhodium tetraacetate; Selectfluor; trifluoroacetic acid; trifluoroacetic anhydride at 70℃; for 10h; Sealed tube; regioselective reaction;

57%	With iodobenzene; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; tert-butylammonium hexafluorophosphate(V); trifluoroacetic acid; trifluoroacetic anhydride at 50℃; for 8h; Electrochemical reaction;
31%	With dipotassium peroxodisulfate; palladium diacetate; trifluoroacetic acid; trifluoroacetic anhydride at 100℃; for 10h; regioselective reaction;
	Multi-step reaction with 2 steps 1: bis-[(trifluoroacetoxy)iodo]benzene / 1,2-dichloro-ethane / 2 h / 80 °C 2: silica gel / hexane; dichloromethane
	With water; copper(II) sulfate
	Multi-step reaction with 2 steps 1: toluene-4-sulfonic acid / toluene / 36 h / Dean-Stark; Reflux; Inert atmosphere 2: tetrakis(actonitrile)copper(I) hexafluorophosphate; dihydrogen peroxide / acetone; water / 0.5 h / 20 °C

Reference： [1]Choy, Pui Ying; Kwong, Fuk Yee [Organic Letters, 2013, vol. 15, # 2, p. 270 - 273]
[2]Shan, Gang; Yang, Xinglin; Ma, Linlin; Rao, Yu [Angewandte Chemie - International Edition, 2012, vol. 51, # 52, p. 13070 - 13074][Angew. Chem., 2012, vol. 124, # 52, p. 13247 - 13251,5]
[3]Shan, Gang; Han, Xuesong; Lin, Yun; Yu, Shanyou; Rao, Yu [Organic and Biomolecular Chemistry, 2013, vol. 11, # 14, p. 2318 - 2322]
[4]Massignan, Leonardo; Tan, Xuefeng; Meyer, Tjark H.; Kuniyil, Rositha; Messinis, Antonis M.; Ackermann, Lutz [Angewandte Chemie - International Edition, 2020, vol. 59, # 8, p. 3184 - 3189][Angew. Chem., 2020, vol. 132, p. 3210 - 3215,6]
[5]Rao, Yu [Synlett, 2013, vol. 24, # 19, p. 2472 - 2476]
[6]Mo, Fanyang; Trzepkowski, Louis J.; Dong, Guangbin [Angewandte Chemie - International Edition, 2012, vol. 51, # 52, p. 13075 - 13079][Angew. Chem., 2012, vol. 124, # 52, p. 13252 - 13256,5]
[7]Current Patent Assignee: DOW INC - US2839541, 1955, A
[8]Trammell, Rachel; D'Amore, Lorenzo; Cordova, Alexandra; Polunin, Pavel; Xie, Nan; Siegler, Maxime A.; Belanzoni, Paola; Swart, Marcel; Garcia-Bosch, Isaac [Inorganic Chemistry, 2019, vol. 58, # 11, p. 7584 - 7592]

4
[ 93-99-2 ]
[ 117-99-7 ]

Yield	Reaction Conditions	Operation in experiment
99%	With aluminum (III) chloride In N,N-dimethyl-formamide at 210℃; for 3h;
	With aluminium trichloride at 190℃;

Reference： [1]Location in patent: experimental part Kwon, Eun Mi; Kim, Cheol Gi; Goh, Ah Ra; Park, Jinseu; Jun, Jong-Gab [Bulletin of the Korean Chemical Society, 2012, vol. 33, # 6, p. 1939 - 1944]
[2]Cullinane et al. [Recueil des Travaux Chimiques des Pays-Bas, 1937, vol. 56, p. 627,629][Journal of the Chemical Society, 1939, p. 151]

5
[ 117-99-7 ]
[ 78-77-3 ]
[ 187093-06-7 ]

Yield	Reaction Conditions	Operation in experiment
94%	With potassium phosphate In dimethyl sulfoxide at 60℃; for 3h;
60%	With caesium carbonate In acetonitrile at 50℃;
60%	With caesium carbonate In acetonitrile at 50℃; Inert atmosphere;

Reference： [1]Sharshira, Essam Mohamed; Shimada, Satoru; Okamura, Mutsuo; Hasegawa, Eietsu; Horaguchi, Takaaki [Journal of Heterocyclic Chemistry, 1996, vol. 33, # 6, p. 1797 - 1805]
[2]Soldi, Cristian; Lamb, Kellan N.; Squitieri, Richard A.; Gonzlez-Lpez, Marcos; Di Maso, Michael J.; Shaw, Jared T. [Journal of the American Chemical Society, 2014, vol. 136, # 43, p. 15142 - 15145]
[3]Lamb, Kellan N.; Squitieri, Richard A.; Chintala, Srinivasa R.; Kwong, Ada J.; Balmond, Edward I.; Soldi, Cristian; Dmitrenko, Olga; Castiñeira Reis, Marta; Chung, Ryan; Addison, J. Bennett; Fettinger, James C.; Hein, Jason E.; Tantillo, Dean J.; Fox, Joseph M.; Shaw, Jared T. [Chemistry - A European Journal, 2017, vol. 23, # 49, p. 11843 - 11855]
[4]Bonnard; Meyer-Oulif [Bulletin de la Societe Chimique de France, 1931, vol. <4>49, p. 1303,1305,1306]

6
[ 117-99-7 ]
[ 100-39-0 ]
[ 93254-81-0 ]

Yield	Reaction Conditions	Operation in experiment
100%	With potassium carbonate; potassium iodide In acetone Heating;
98%	With caesium carbonate In acetonitrile at 50℃;
98%	With caesium carbonate In acetonitrile at 50℃; Inert atmosphere;

	With sodium methylate 1.) MeOH, 1 h, 2.) reflux, overnight; Yield given. Multistep reaction;
	With potassium carbonate; potassium iodide In acetone at 50℃;

Reference： [1]Cheung, Wai-Hung; Zheng, Shi-Long; Yu, Wing-Yiu; Zhou, Guo-Chuan; Che, Chi-Ming [Organic Letters, 2003, vol. 5, # 14, p. 2535 - 2538]
[2]Soldi, Cristian; Lamb, Kellan N.; Squitieri, Richard A.; Gonzlez-Lpez, Marcos; Di Maso, Michael J.; Shaw, Jared T. [Journal of the American Chemical Society, 2014, vol. 136, # 43, p. 15142 - 15145]
[3]Lamb, Kellan N.; Squitieri, Richard A.; Chintala, Srinivasa R.; Kwong, Ada J.; Balmond, Edward I.; Soldi, Cristian; Dmitrenko, Olga; Castiñeira Reis, Marta; Chung, Ryan; Addison, J. Bennett; Fettinger, James C.; Hein, Jason E.; Tantillo, Dean J.; Fox, Joseph M.; Shaw, Jared T. [Chemistry - A European Journal, 2017, vol. 23, # 49, p. 11843 - 11855]
[4]Bonnard; Meyer-Oulif [Bulletin de la Societe Chimique de France, 1931, vol. <4>49, p. 1303,1305,1306]
[5]Wagner, Peter J.; Meador, Michael A.; Park, Bong-Ser [Journal of the American Chemical Society, 1990, vol. 112, # 13, p. 5199 - 5211]
[6]Matsuda, Takanori; Shigeno, Masanori; Murakami, Masahiro [Journal of the American Chemical Society, 2007, vol. 129, # 40, p. 12086 - 12087]

7
[ 117-99-7 ]
[ 75-26-3 ]
[ 133745-29-6 ]

Yield	Reaction Conditions	Operation in experiment
88%	With caesium carbonate In acetonitrile at 50℃;
88%	With caesium carbonate In acetonitrile at 50℃; Inert atmosphere;

Reference： [1]Soldi, Cristian; Lamb, Kellan N.; Squitieri, Richard A.; Gonzlez-Lpez, Marcos; Di Maso, Michael J.; Shaw, Jared T. [Journal of the American Chemical Society, 2014, vol. 136, # 43, p. 15142 - 15145]
[2]Lamb, Kellan N.; Squitieri, Richard A.; Chintala, Srinivasa R.; Kwong, Ada J.; Balmond, Edward I.; Soldi, Cristian; Dmitrenko, Olga; Castiñeira Reis, Marta; Chung, Ryan; Addison, J. Bennett; Fettinger, James C.; Hein, Jason E.; Tantillo, Dean J.; Fox, Joseph M.; Shaw, Jared T. [Chemistry - A European Journal, 2017, vol. 23, # 49, p. 11843 - 11855]
[3]Bonnard; Meyer-Oulif [Bulletin de la Societe Chimique de France, 1931, vol. <4>49, p. 1303,1305,1306]

8
[ 117-99-7 ]
[ 74-88-4 ]
[ 2553-04-0 ]

Yield	Reaction Conditions	Operation in experiment
96.9%	With sodium hydroxide In dimethyl sulfoxide at 40℃;
95%	With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 6h;	13.1 Synthesis of 13.1 (2-methoxy-phenyl)(phenyl)-methanone (2-Hydroxy-phenyl)(phenyl)-methanone (1.98 g, 10 mmol)Soluble in N,N-dimethylformamide (30ml),Add anhydrous potassium carbonate (2.76 g, 20 mmol),Stir at room temperature,Add methyl iodide (2.84 g, 20 mmol),The reaction was carried out for 6 h at room temperature.TLC monitoring,After the reaction is completed,Quenched with water,Extract with dichloromethane (3 x 30 ml).After combining the organic phases,Water,Washed with saturated saline,Drying the organic phase with anhydrous sodium sulfate,Rotating to remove the solvent,Purification by silica column chromatographyPetroleum ether/dichloromethane (4/1) elution,The product was obtained as a brown solid (yield: EtOAc) (yield: 95%).
95%	With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 6h;	17.1 17.1 Synthesis of (2-methoxyphenyl)(phenyl)-methanone (2-hydroxy-phenyl)(phenyl)-methanone (1.98 g, 10 mmol) is dissolved in N,N-dimethylformamide (30 mi); anhydrous potassium carbonate (2.76 g, 20 mmol) is added; the above materials are stirred at room temperature; then iodomethane (2.84 g, 20 mmol) is dropped; and the reaction is carried out for 6 h at room temperature. TLC is used for monitoring; after the reaction is completed, the materials are quenched by addition of water and extracted with dichloromethane (3×30 ml). After being merged, the organic phase is washed with water and a saturated salt solution, dried with anhydrous sodium sulfate, desolvated by the rotary evaporator, purified by silicon oxide column chromatography and eluted by ligroin/dichloromethane (4/1) to obtain 2.01 g of the brown solid product, with a yield of 95%. 1H NMR (400 MHz, CDCl3), δ: 7.82-7.80 (m, 2H), 7.57-7.53 (m, 1H), 7.49-7.41 (m, 3H), 7.37 (dd, J=1.6, 7.6 Hz, 1H), 7.04 (t, J=7.6 Hz, 1H), 6.98 (d, J=8.4 Hz, 1H), 3.73 (s, 3H).

85%	With potassium phosphate In acetone for 3h; Heating;
	With potassium carbonate at 100℃;

Reference： [1]Tomioka, Hideo; Nakanishi, Keisaku; Izawa, Yasuji [Journal of the Chemical Society. Perkin transactions I, 1991, # 2, p. 465 - 470]
[2]Current Patent Assignee: Dalian Institute of Chemical Physics (in: CAS); CHINESE ACADEMY OF SCIENCES - CN108383775, 2018, A Location in patent: Paragraph 0377; 0379-0382
[3]Current Patent Assignee: CHINESE ACADEMY OF SCIENCES; Dalian Institute of Chemical Physics (in: CAS) - US2021/155591, 2021, A1 Location in patent: Paragraph 0383-0384
[4]Sharshira, Essam Mohamed; Shimada, Satoru; Okamura, Mutsuo; Hasegawa, Eietsu; Horaguchi, Takaaki [Journal of Heterocyclic Chemistry, 1996, vol. 33, # 6, p. 1797 - 1805]
[5]Cohn [Monatshefte fur Chemie, 1896, vol. 17, p. 102]

9
[ 117-99-7 ]
[ 107-30-2 ]
[ 71103-99-6 ]

Yield	Reaction Conditions	Operation in experiment
91%	With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 12h;	1.1 Method 4-2-1: General procedure: Take the methoxymethyl ether protecting group as an example.The 2-hydroxy-diaryl ketone compound 6 (10 mmol) was dissolved in dichloromethane (50 ml).Add diisopropylethylamine (30 mmol) and stir at room temperature.Chloromethyl methyl ether(20 mmol). Heated for 12 hours,TLC monitoring,After the reaction is completed.The reaction solution was cooled to room temperature.Rotating to remove the solvent,Purification by silica column chromatographyA 2-methoxymethoxy-diaryl ketone compound 5 can be obtained.
91%	With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 12h; Reflux;	2.1 2.1 Synthesis of (2-methoxymethoxy-phenyl)(phenyl)methanone (2-hydroxy-phenyl)(phenyl)-methanone (1.98 g, 10 mmol) is dissolved in dichloromethane (50 ml), diisopropyl ethylamine (30 mmol) is added, the above materials are stirred at room temperature, and chloromethyl methyl ether (20 mmol) is added. The above materials are heated to reflux, for 12 hours, and the reaction is monitored by TLC until the reaction is completed. Tire reaction liquid is cooled to room temperature, the solvent is removed by rotary evaporation, and the product is purified by silica column chromatography to obtain 2.2 g of brown oily product of (2-methoxymethoxy-phenyl)(phenyl)-methanone (yield 91%). 1H NMR (400 MHz, CDCl3), δ: 7.84-7.82 (m, 2H), 7.58-7.54 (m, 1H), 7.47-7.42 (m, 3H), 7.37 (q, J=12.0 Hz, 1H), 7.21 (d, J=8.0 Hz, 1H), 7.12-7.09 (m, 1H), 5.05 (s, 2H), 3.29 (s, 3H).
	With potassium carbonate In acetone

	With potassium carbonate In acetone Reflux;	II.1 1. Preparation of (2-(methoxymethoxy)phenyl)(phenyl)methanone To a stirring solution of 2-hydroxybenzophenone (3.0 g, 15.1 mmol) and K2CO3 (9.94 g, 71.9 mmol) in acetone (80 mL) under reflux was added MOMCl (2.9 mL, 37.8 mmol) and allowed to stir overnight. The reaction was then cooled to 23° C., diluted with EtOAc, washed with 2N NaOH (3*), the organic phase dried (Na2SO4), filtered and concentrated to provide the product (605 mg) as an oil: 1H NMR (400 MHz, DMSO-d6) δ ppm 7.67-7.72 (2H, m), 7.63 (1H, d, J=7.07 Hz), 7.48-7.54 (3H, m), 7.34 (1H, dd, J=7.33, 1.52 Hz), 7.24 (1H, d, J=8.34 Hz), 7.13 (1H, t, J=7.45 Hz), 5.08 (2H, s), 3.13 (3H, s).
	With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 25℃; for 18h;

Reference： [1]Current Patent Assignee: Dalian Institute of Chemical Physics (in: CAS); CHINESE ACADEMY OF SCIENCES - CN108383775, 2018, A Location in patent: Paragraph 0149; 0154; 0156-0159
[2]Current Patent Assignee: CHINESE ACADEMY OF SCIENCES; Dalian Institute of Chemical Physics (in: CAS) - US2021/155591, 2021, A1 Location in patent: Paragraph 0216-0217
[3]Forrester,A.R. et al. [Journal of the Chemical Society. Perkin transactions I, 1979, p. 621 - 631]
[4]Current Patent Assignee: BRISTOL-MYERS SQUIBB CO - US2010/48581, 2010, A1 Location in patent: Page/Page column 33
[5]Chen, Jinhua; Corson, Laura B.; DiPasquale, Antonio; Dragovich, Peter S.; Eigenbrot, Charles; Evangelista, Marie; Fauber, Benjamin P.; Hitz, Anna; Hong, Rebecca; Labadie, Sharada S.; Lai, Kwong Wah; Liu, Wenfeng; Ma, Shuguang; Malek, Shiva; O'Brien, Thomas; Pang, Jodie; Peterson, David; Purkey, Hans E.; Robarge, Kirk; Salphati, Laurent; Sampath, Deepak; Sideris, Steven; Ultsch, Mark; Wei, BinQing; Xu, Zijin; Yen, Ivana; Yu, Dong; Yue, Qin; Zhou, Aihe [Bioorganic and Medicinal Chemistry Letters, 2022, vol. 59]

10
[ 117-99-7 ]
[ 85-19-8 ]

Reference： [1]Bulletin des Societes Chimiques Belges,1991,vol. 100,p. 539 - 548

11
[ 117-99-7 ]
[ 14061-01-9 ]

Yield	Reaction Conditions	Operation in experiment
76%	With isocyanate de chlorosulfonyle In toluene for 10h; Reflux;	A mixture of 3a (100 mg, 0.5 mmol) was dissolved in toluene (10 mL), ClSO2NCO(70.8 mg, 43.4 mL, 0.5 mmol) was added. Then the reaction mixture was heated at reflux for 10 h. The reaction mixture was washed with H2O (10 mL). The organic layer was then dried over anhydrous Na2SO4, filtered and concentrated. The crude product was loaded on a silica gel column and flashed with 20% ethyl acetate in petroleum ether to afford the desired products 6 as solid.
76%	With isocyanate de chlorosulfonyle In toluene at 80℃; for 10h;
72%	With isocyanate de chlorosulfonyle In toluene at 100 - 105℃; for 3h;

70%	With formic acid; isocyanate de chlorosulfonyle; sodium hydride In N,N-dimethyl acetamide; mineral oil at 0 - 50℃; Inert atmosphere; Neat (no solvent);
60%	Stage #1: 2-Hydroxybenzophenone With sulphamoyl chloride In dichloromethane; N,N-dimethyl acetamide at 0 - 20℃; for 0.166667h; Inert atmosphere; Stage #2: With sodium hydride In dichloromethane; N,N-dimethyl acetamide; mineral oil at 50℃; for 1h;
	Stage #1: 2-Hydroxybenzophenone With formic acid; isocyanate de chlorosulfonyle In N,N-dimethyl acetamide at 0 - 20℃; Cooling with ice; Stage #2: With sodium hydride In N,N-dimethyl acetamide; mineral oil at 20 - 50℃;
	Stage #1: 2-Hydroxybenzophenone With sulphamoyl chloride In N,N-dimethyl acetamide at 20℃; Cooling with ice; Stage #2: With sodium hydride In N,N-dimethyl acetamide; mineral oil at 20 - 50℃;	4. Synthesis of Six-membered Cyclic Sulfonamides General procedure: Anhydrous formic acid (4.0 mmol) was added dropwise to neat chlorosulfonyl isocyanate (4.0 mmol) at 0 °C with rapid stirring. Vigorous gas evolution was observed during the addition process. The resulting white solid was stirred at room temperature until gas evolution ceased (1-2 h). To the resulting sulfamoyl chloride (ClSO2NH2) was added 2-hydroxybenzophenone derivatives 7a-j (2.0 mmol). After the mixture was cooled under ice-cooling, 3 mL of DMA (N, N-dimethyl-acetamide) was slowly added. After the ice-cooling was moved, the mixture was stirring for 10 min, and sodium hydride (96 mg of 60 % dispersion in mineral oil, 2.4 mmol) was added in portions. After stirring for 30 min at rt another sodium hydride (96 mg of 60 % dispersion in mineral oil, 2.4 mmol) was added in portions again. After stirring for 1 h at rt the reaction mixture was allowed to stir overnight (8-12 h) at 50 °C. The reaction was quenched by the addition of 5 mL of H2O and the aqueous layer was extracted with 3 x 10 mL of EtOAc. The combined organic layers were washed with 1 x 10 mL of H2O and 1 x 10 mL of brine, and concentrated under reduced pressure. Purification by chromatography on silica gel afforded (petroleum ether/EtOAc = 3/1) afforded the desired imines 4a-j as a white solid in 66~73% yield.

Reference： [1]Wang, Dahai; Cui, Sunliang [Tetrahedron, 2015, vol. 71, # 45, p. 8511 - 8516]
[2]Tong, Zhou; Tang, Zhi; Au, Chak-Tong; Qiu, Renhua [Journal of Organic Chemistry, 2020, vol. 85, # 13, p. 8533 - 8543]
[3]Kamal, Ahmed; Sattur, P. B. [Synthesis, 1981, # 4, p. 272 - 273]
[4]Wang, You-Qing; Yu, Chang-Bin; Wang, Da-Wei; Wang, Xiao-Bing; Zhou, Yong-Gui [Organic Letters, 2008, vol. 10, # 10, p. 2071 - 2074]
[5]Li, Bowen; Chen, Jianzhong; Zhang, Zhenfeng; Gridnev, Ilya D.; Zhang, Wanbin [Angewandte Chemie - International Edition, 2019, vol. 58, # 22, p. 7329 - 7334][Angew. Chem., 2019, vol. 131, p. 7407 - 7412,6]
[6]Jiang, Chunhui; Lu, Yixin; Hayashi, Tamio [Angewandte Chemie - International Edition, 2014, vol. 53, # 37, p. 9936 - 9939][Angew. Chem., 2014, vol. 126, # 37, p. 10094 - 10097,4]
[7]Ming, Zong-Yao; Li, Kang-Rui; Meng, Fan-Jie; Shi, Lei; Jiang, Wen-Feng [Tetrahedron Letters, 2020, vol. 61, # 27]

12
[ 117-99-7 ]
[ 98-88-4 ]
[ 33719-60-7 ]

Yield	Reaction Conditions	Operation in experiment
96%	With pyridine for 2h; Heating;
86%	With pyridine In dichloromethane Ambient temperature;
83%	In pyridine at 40℃; for 0.5h;

78%

With sodium hydroxide In dichloromethane at 20℃; for 3h; Inert atmosphere;

Reference： [1]Kocher, Christoph; Weder, Christoph; Smith, Paul [Journal of Materials Chemistry, 2003, vol. 13, # 1, p. 9 - 15]
[2]Fuerstner, Alois; Jumbam, Denis N. [Tetrahedron, 1992, vol. 48, # 29, p. 5991 - 6010]
[3]Effenberger, Franz; Gutmann, Rainer [Chemische Berichte, 1982, vol. 115, # 3, p. 1089 - 1102]
[4]Location in patent: experimental part Kwon, Eun Mi; Kim, Cheol Gi; Goh, Ah Ra; Park, Jinseu; Jun, Jong-Gab [Bulletin of the Korean Chemical Society, 2012, vol. 33, # 6, p. 1939 - 1944]

13
[ 117-99-7 ]
[ 75-03-6 ]
[ 127154-52-3 ]

Yield	Reaction Conditions	Operation in experiment
92.5%	With sodium hydroxide In dimethyl sulfoxide at 40℃;
92%	With potassium phosphate In acetone for 3h; Heating;
	With dibenzo-18-crown-6; potassium carbonate In acetonitrile for 12h;

Reference： [1]Tomioka, Hideo; Nakanishi, Keisaku; Izawa, Yasuji [Journal of the Chemical Society. Perkin transactions I, 1991, # 2, p. 465 - 470]
[2]Sharshira, Essam Mohamed; Shimada, Satoru; Okamura, Mutsuo; Hasegawa, Eietsu; Horaguchi, Takaaki [Journal of Heterocyclic Chemistry, 1996, vol. 33, # 6, p. 1797 - 1805]
[3]Shailaja; Kaanumalle, Lakshmi S.; Sivasubramanian, Karthikeyan; Natarajan, Arunkumar; Ponchot, Keith J.; Pradhan, Ajit; Ramamurthy [Organic and Biomolecular Chemistry, 2006, vol. 4, # 8, p. 1561 - 1571]

14
[ 117-99-7 ]
[ 1119-51-3 ]
[ 121150-34-3 ]

Yield	Reaction Conditions	Operation in experiment
93%	With potassium carbonate
6.91 g	With potassium carbonate In acetonitrile at 50℃; for 22h;	60 Synthesis of intermediate 19a: General procedure: A mixture of 4-bromo-l -butene [CAS 5162-44-7] (10.2 mL, 101 mol), (2- hydroxyphenyl)(phenyl)methanone [CAS 117-99-7] (5 g, 25.224 mol) and K2CO3 (10.46 g, 75.673 mol) in CH3CN (66 mL) was stirred at 50°C for 18 h. The reaction was not complete and 4-bromo-l -butene (7.0 mL, 70 mmol) was added again. The mixture was stirred for another 24 h at 50°C. The mixture was filtered and concentrated under reduced pressure. The residue was purified by flash chromatography over silica gel (20-45 pm, 120 g, heptane/EtOAc 90/10). The pure fractions were collected and concentrated to dryness under reduced pressure to give (2-(but-3-en-l-yloxy)phenyl)(phenyl)methanone (intermediate 19a, 2 g).

Reference： [1]Motoki, Shinichi; Watanabe, Tsumoru; Saito, Takao [Tetrahedron Letters, 1989, vol. 30, # 2, p. 189 - 192]
[2]Current Patent Assignee: JOHNSON & JOHNSON INC - WO2020/75080, 2020, A1 Location in patent: Page/Page column 53; 54; 159; 160

15
[ 117-99-7 ]
[ 644-97-3 ]
[ 77086-08-9 ]

Yield	Reaction Conditions	Operation in experiment
80.5%	With triethylamine In tetrahydrofuran -78 deg C -> 25 deg C;

Reference： [1]Harper, S. D.; Arguengo, Anthony J. [Journal of the American Chemical Society, 1982, vol. 104, # 9, p. 2497 - 2501]

16
[ 117-99-7 ]
[ 106-95-6 ]
[ 121150-32-1 ]

Yield	Reaction Conditions	Operation in experiment
100%	With potassium carbonate In acetone at 50℃;	Step 2: 2-(Allyloxy)-4,6-dimethoxybenzaldehyde (3b) General procedure: To a solution of the product from step 1 (1.00 g, 5.5 mmol) and allyl bromide (0.71 mL, 8.2 mmol) in acetone (10 mL) was added K2CO3 (1.51 g, 11.0 mmol). The mixture was heated to 50°C until the starting material was completely consumed, cooled to ambient temperature and hydrolysed by addition of a semisaturated aqueous solution of NaCl (20 mL). Ethyl acetate (10 mL) was added, the organic layer was separated and the aqueous layer was extracted twice with ethyl acetate (20 mL each). The combined organic extracts were dried with MgSO4, filtered and evaporated. The residue was purified by chromatography on silica, using hexane-MTBE mixtures of increasing polarity as eluent, to furnish the title compound 3b (0.93 g, 4.2 mmol, 76%).
98%	With potassium phosphate In acetone for 3h; Heating;
94%	With potassium carbonate

90%	With potassium carbonate In N,N-dimethyl-formamide Ambient temperature;
90%	With potassium carbonate In acetone for 40h; Heating;
44%	With potassium carbonate In N,N-dimethyl-formamide for 23h; Ambient temperature;
	With potassium carbonate In acetonitrile for 15h; Heating;
	With potassium carbonate In acetone at 60℃; for 16h;

Reference： [1]Schmidt, Bernd; Riemer, Martin [Synthesis, 2016, vol. 48, # 1, p. 141 - 149]
[2]Sharshira, Essam Mohamed; Shimada, Satoru; Okamura, Mutsuo; Hasegawa, Eietsu; Horaguchi, Takaaki [Journal of Heterocyclic Chemistry, 1996, vol. 33, # 6, p. 1797 - 1805]
[3]Motoki, Shinichi; Watanabe, Tsumoru; Saito, Takao [Tetrahedron Letters, 1989, vol. 30, # 2, p. 189 - 192]
[4]Cadogan, J. I. G.; Hutchison, H. Susan; McNab, Hamish [Journal of the Chemical Society. Perkin transactions I, 1991, # 2, p. 385 - 393]
[5]Heaney, Frances; O'Mahony, Colm [Journal of the Chemical Society. Perkin transactions I, 1998, # 2, p. 341 - 349]
[6]Black, Michael; Cadogan; Leardini, Rino; McNab, Hamish; McDougald, Graham; Nanni, Daniele; Reed, David; Zompatori, Alberto [Journal of the Chemical Society. Perkin transactions I, 1998, # 11, p. 1825 - 1832]
[7]Gabriele, Bartolo; Mancuso, Raffaella; Salerno, Giuseppe; Costa, Mirco [Advanced Synthesis and Catalysis, 2006, vol. 348, # 9, p. 1101 - 1109]
[8]Tao, Leyi; Wei, Yin; Shi, Min [Chemistry - An Asian Journal, 2021, vol. 16, # 17, p. 2463 - 2468]

17
[ 117-99-7 ]
[ 3282-30-2 ]
2-pivaloyloxybenzophenone [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
89%	With triethylamine In dichloromethane at 25℃; for 1h;
	With pyridine at 50℃; for 2h;

Reference： [1]Imaki, Katsuhiro; Okada, Takanori; Nakayama, Yoshisuke; Nagao, Yuuki; Kobayashi, Kaoru; Sakai, Yasuhiro; Mohri, Tetsuya; Amino, Takaaki; Nakai, Hisao; Kawamura, Masanori [Bioorganic and Medicinal Chemistry, 1996, vol. 4, # 12, p. 2115 - 2134]
[2]Miyano, Masateru; Deason, James R.; Nakao, Akira; Stealey, Michael A.; Villamil, Clara I.; et al. [Journal of Medicinal Chemistry, 1988, vol. 31, # 5, p. 1052 - 1061]

18
[ 117-99-7 ]
[ 589-15-1 ]
[2-(4-Bromo-benzyloxy)-phenyl]-phenyl-methanone [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
92%	With caesium carbonate In acetonitrile at 50℃;
92%	With caesium carbonate In acetonitrile at 50℃; Inert atmosphere;
57%	With sodium hydroxide In ethanol 1.) 30 min., reflux; 2.) 3 h, reflux;

Reference： [1]Soldi, Cristian; Lamb, Kellan N.; Squitieri, Richard A.; Gonzlez-Lpez, Marcos; Di Maso, Michael J.; Shaw, Jared T. [Journal of the American Chemical Society, 2014, vol. 136, # 43, p. 15142 - 15145]
[2]Lamb, Kellan N.; Squitieri, Richard A.; Chintala, Srinivasa R.; Kwong, Ada J.; Balmond, Edward I.; Soldi, Cristian; Dmitrenko, Olga; Castiñeira Reis, Marta; Chung, Ryan; Addison, J. Bennett; Fettinger, James C.; Hein, Jason E.; Tantillo, Dean J.; Fox, Joseph M.; Shaw, Jared T. [Chemistry - A European Journal, 2017, vol. 23, # 49, p. 11843 - 11855]
[3]Hellwinkel; Goke [Synthesis, 1995, # 9, p. 1135 - 1141]

19
[ 117-99-7 ]
[ 3446-91-1 ]
4-(2-Benzoyl-phenoxymethyl)-N,N-dimethyl-benzenesulfonamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
64%	With aluminum oxide; cesium fluoride In N,N-dimethyl-formamide for 4h; Ambient temperature;

Reference： [1]Hellwinkel; Goke [Synthesis, 1995, # 9, p. 1135 - 1141]

20
[ 591-50-4 ]
[ 90-02-8 ]
[ 117-99-7 ]

Yield	Reaction Conditions	Operation in experiment
95%	With tetrabutylammomium bromide; sodium hydroxide; palladium dichloride In water at 100℃; for 0.75h; Green chemistry;	General procedure for the preparation of 2-hydroxyarylketones from the reaction of 2-hydroxybenzaldehydes with aryl halides General procedure: In a 50 mL round bottom flask equipped with a magnetic stirring bar, tetrabutylammonium bromide (0.5 mmol, 0.16 g) was added and heated at 100 °C to be melted. Then a mixture of PdCl2 (3 mol%, 0.0053 g), aqueous NaOH (2.0 mmol, 0.08 g of NaOH dissolved in 2 mL H2O), hydroxybenzaldehyde (1.0 mmol), and arylhalide (2.0 mmol) were added to molten tetrabutylammonium bromide. The progress of the reaction was monitored by TLC. After the appropriate reaction time, the mixture was cooled to room temperature and extracted with diethyl ether (3 × 5 mL). The organic layer was isolated and dried over anhydrous Na2SO4 and purified by column chromatography over silica gel using n-hexane/ethyl acetate as eluent to afford the highly pure desired products (Table 2).
94%	With nickel(II) chloride hexahydrate; tetrabutylammomium bromide; sodium hydroxide In ethylene glycol at 120℃; for 2h;
93%	With 1,4-diaza-bicyclo[2.2.2]octane; palladium dichloride In water at 100℃; for 5h;

87%	With dicarbonylacetylacetonato rhodium (I); sodium hydrogencarbonate In N,N-dimethyl-formamide at 100℃; for 0.5h; Schlenk technique; Inert atmosphere;
83%	With palladium diacetate; potassium carbonate; catacxium A In N,N-dimethyl-formamide at 120℃; for 12h; Schlenk technique; Inert atmosphere;	General procedure for the synthesis of xanthone General procedure: To an oven-dried 25 mL Schlenk tube containing a stirring bar was added 4.5 mg Pd(OAc)2 (0.02 mmol), 15.7mg nBuPAd2 (0.44 mmol), 2-bromofluorobenzene (0.50 mmol), salicylaldehyde (0.50 mmol), potassium carbonate (1.0 mmol). The Schlenk tube was vacuumed and then purged with argon before DMF (2.0 mL) was injected using a syringe. Afterwards the Schlenk tube in the ice bath was degassed by evacuation and back fillingwith argon three times. The reaction mixture was then stirred for 12 h at 120 °C. After the reaction was complete,the reaction mixture was diluted with water (5 mL), extracted with ethyl acetate (3 x 10 mL) and dried withanhydrous Na2SO4. After filtration and addition of silica gel into the solution, the organic solvent was reduced evaporated. The crude product was purified by column chromatography using ethyl acetate/n-pentane.
96 % Chromat.	With N-benzyl-N,N,N-triethylammonium chloride; sodium carbonate; palladium dichloride In N,N-dimethyl-formamide at 100℃; for 4h;

Reference： [1]Nowrouzi, Najmeh; Motevalli, Somayeh; Tarokh, Dariush [Journal of Molecular Catalysis A: Chemical, 2015, vol. 396, p. 224 - 230]
[2]Nowrouzi; Zarei; Roozbin [RSC Advances, 2015, vol. 5, # 124, p. 102448 - 102453]
[3]Nowrouzi, Najmeh; Tarokh, Dariush [Journal of the Iranian Chemical Society, 2016, vol. 13, # 8, p. 1493 - 1497]
[4]Rao, Maddali L. N.; Ramakrishna, Boddu S. [European Journal of Organic Chemistry, 2017, vol. 2017, # 34, p. 5080 - 5093]
[5]Shen, Chaoren; Wu, Xiao-Feng [Synlett, 2016, vol. 27, # 8, p. 1269 - 1273]
[6]Satoh, Tetsuya; Itaya, Tomoaki; Miura, Masahiro; Nomura, Masakatsu [Chemistry Letters, 1996, # 9, p. 823 - 824]

21
[ 89-95-2 ]
[ 1483-73-4 ]
[ 117-99-7 ]

Reference： [1]Synthetic Communications,2000,vol. 30,p. 531 - 536

22
[ 89-95-2 ]
[ 71-43-2 ]
[ 117-99-7 ]

Yield	Reaction Conditions	Operation in experiment
84%	Stage #1: benzene With polymer-supported phenyliodine(III) diacetate; sulfuric acid In acetic acid at 20℃; for 60h; Stage #2: 2-methyl-benzyl alcohol With sodium carbonate In N,N-dimethyl-formamide at 60 - 70℃; for 4h;

Reference： [1]Chen; Chen [Synlett, 2000, # 8, p. 1175 - 1177]

23
[ 54187-96-1 ]
[ 117-99-7 ]
[ 360782-05-4 ]

Yield	Reaction Conditions	Operation in experiment
97%	Stage #1: 2-Hydroxybenzophenone With sodium hydroxide In ethanol at 20℃; for 5h; Stage #2: 1-(chloromethyl)-1H-benzotriazole In N,N-dimethyl-formamide at 70℃; for 12h; Further stages.;

Reference： [1]Katritzky; Ji; Fang; Prakash [Journal of Organic Chemistry, 2001, vol. 66, # 16, p. 5613 - 5615]

24
[ 117-99-7 ]
[ 111098-56-7 ]
[ 360782-06-5 ]

Yield	Reaction Conditions	Operation in experiment
87%	Stage #1: 2-Hydroxybenzophenone With sodium hydroxide In ethanol at 20℃; for 5h; Stage #2: 1-(benzotriazol-1-yl)-1-chloroethane In N,N-dimethyl-formamide at 70℃; for 12h; Further stages.;

Reference： [1]Katritzky; Ji; Fang; Prakash [Journal of Organic Chemistry, 2001, vol. 66, # 16, p. 5613 - 5615]

25
[ 117-99-7 ]
[ 111098-59-0 ]
[2-(1-benzotriazol-1-ylbutoxy)phenyl](phenyl)methanone [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
85%	Stage #1: 2-Hydroxybenzophenone With sodium hydroxide In ethanol at 20℃; for 5h; Stage #2: 1-(benzotriazol-1-yl)-1-chloro-2-methylpropane In N,N-dimethyl-formamide at 70℃; for 12h; Further stages.;

Reference： [1]Katritzky; Ji; Fang; Prakash [Journal of Organic Chemistry, 2001, vol. 66, # 16, p. 5613 - 5615]

26
[ 117-99-7 ]
[ 54758-71-3 ]

Yield	Reaction Conditions	Operation in experiment
100%	With ammonia In methanol at 20℃; for 16h; Cooling with ice;
96%	With ammonia In methanol at 20℃; Sealed tube;
70%	With 1,1,1,3,3,3-hexamethyl-disilazane; scandium tris(trifluoromethanesulfonate) In chlorobenzene at 90℃; for 2h; Inert atmosphere;

70%	With ammonia In methanol Inert atmosphere;
50%	With piperidine; ammonium iodide at 35℃; for 40h;
	With ammonium iodide; calcium sulfate; triethylamine In acetonitrile at 20℃; for 44.5h;
	With ammonia In methanol at 20℃; for 2h; Inert atmosphere;
	With ammonia In methanol at 20℃;
11 %Spectr.	With Ru(OCOCH₃)2{(S)-2,2'-bis(diphenylphosphino)-1,1'-dinaphthyl)}; ammonium acetate; hydrogen In methanol at 80℃; for 24h; Autoclave;

Reference： [1]Nguyen, Thanh Binh; Wang, Qian; Gueritte, Franioise [Chemistry - A European Journal, 2011, vol. 17, # 35, p. 9576 - 9580]
[2]Choubane, Houcine; Garrido-Castro, Alberto F.; Alvarado, Cuauhtemoc; Martín-Somer, Ana; Guerrero-Corella, Andrea; Daaou, Mortada; Díaz-Tendero, Sergio; Carmen Maestro; Fraile, Alberto; Alemán, José [Chemical Communications, 2018, vol. 54, # 27, p. 3399 - 3402]
[3]Hirazawa, Yoshinobu; Kadota, Tetsuya; Kondo, Yuta; Morimoto, Hiroyuki; Morisaki, Kazuhiro; Ohshima, Takashi [Organic Letters, 2020, vol. 22, # 1, p. 120 - 125]
[4]Clarkson, Guy J.; Wills, Martin; Zheng, Ye [Organic Letters, 2020]
[5]Location in patent: scheme or table Crecente-Campo, Jose; Vazquez-Tato, M. Pilar; Seijas, Julio A. [European Journal of Organic Chemistry, 2010, # 21, p. 4130 - 4135]
[6]Mizufune, Hideya; Irie, Hiroyuki; Katsube, Susumu; Okada, Tadataka; Mizuno, Yukio; Arita, Miichiro [Tetrahedron, 2001, vol. 57, # 35, p. 7501 - 7506]
[7]Chen, Cheng-Yi; Andreani, Teresa; Li, Hongmei [Organic Letters, 2011, vol. 13, # 23, p. 6300 - 6303]
[8]Guerrero-Corella, Andrea; Esteban, Francisco; Iniesta, Manuel; Martín-Somer, Ana; Parra, Mario; Díaz-Tendero, Sergio; Fraile, Alberto; Alemán, Jose [Angewandte Chemie - International Edition, 2018, vol. 57, # 19, p. 5350 - 5354][Angew. Chem., 2018, vol. 130, # 19, p. 5448 - 5452,5]
[9]Hu, Le' an; Zhang, Yao; Zhang, Qing-Wen; Yin, Qin; Zhang, Xumu [Angewandte Chemie - International Edition, 2020, vol. 59, # 13, p. 5321 - 5325][Angew. Chem., 2020, vol. 132, p. 5359 - 5363]

27
[ 35654-56-9 ]
[ 117-99-7 ]
{2-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}(phenyl)methanone [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
100%	With dmap In 1,2-dichloro-benzene at 160℃; for 4h;
5%	at 170℃; for 0.333333h;
	Stage #1: 6,7-dimethoxy-4-chloroquinoline; 2-Hydroxybenzophenone With dmap In 1,2-dichloro-benzene at 160℃; for 4h; Stage #2: With potassium hydroxide In chloroform; water	Compound 62: {2-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}(phenyl)-methanone Compound 62: {2-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}(phenyl)-methanone; 4-Chloro-6,7-dimethoxyquinoline (58 mg), 2-hydroxybenzophenone (271 mg), and 4-dimethylaminopyridine (166 mg) were suspended in o-dichlorobenzene (5 ml), and the suspension was stirred at 160°C for 4 hr. The reaction solution was cooled to room temperature, and the solvent was then removed therefrom by distillation under the reduced pressure. Chloroform was added to the residue, and the mixture was washed with a 1 N aqueous potassium hydroxide solution and saturated brine and was dried over anhydrous sodium sulfate. The solvent was removed therefrom by distillation under the reduced pressure, and the residue was purified by column chromatography using chloroform and by thin layer chromatography using acetone-hexane to quantitatively give 110.4 mg of the title compound. 1H-NMR (CDCl3, 400 MHz): δ 3.82 (s, 3H), 3.99 (s, 3H), 6.43 (d, J = 5.1 Hz, 1H), 6.93 (s, 1H), 7.26 (d, J = 8.3 Hz, 1H), 7.28 - 7.34 (m, 3H), 7.39 - 7.48 (m, 2H), 7.59 - 7.72 (m, 4H), 8.44 (d, J = 5.4 Hz, 1H) Mass spectrometric value (ESI-MS, m/z): 386 (M+1)+

Reference： [1]Location in patent: experimental part Shimizu, Toshiyuki; Kimura, Kaname; Sakai, Teruyuki; Kawakami, Kazuki; Miyazaki, Tetsuko; Nakouji, Masayoshi; Ogawa, Akira; Ohuchi, Hitomi; Shimizu, Kiyoshi [Journal of Medicinal Chemistry, 2008, vol. 51, # 11, p. 3326 - 3329]
[2]Kubo, Kazuo; Ohyama, Shin-Ichi; Shimizu, Toshiyuki; Takami, Atsuya; Murooka, Hideko; Nishitoba, Tsuyoshi; Kato, Shinichiro; Yagi, Mikio; Kobayashi, Yoshiko; Iinuma, Noriko; Isoe, Toshiyuki; Nakamura, Kazuhide; Iijima, Hiroshi; Osawa, Tatsushi; Izawa, Toshio [Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 23, p. 5117 - 5133]
[3]Current Patent Assignee: KIRIN HOLDINGS CO., LTD.; Kyowa Kirin (in: Kirin Holdings) - EP1548008, 2005, A1 Location in patent: Page/Page column 77

28
[ 40473-50-5 ]
[ 117-99-7 ]

Yield	Reaction Conditions	Operation in experiment
75%	With air; Mn₃O₄ nanoparticles In N,N-dimethyl-formamide at 80℃; for 6h;
60%	With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In ethyl acetate at 80℃; for 6h;	4. Synthesis of Six-membered Cyclic Sulfonamides General procedure: IBX (6.0 mmol) was added to a solution of 6a-j (5.0 mmol) in EA (10 mL) at 80 oC. The resulting suspension was stirred for 6 h and then filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel to afford 2-hydroxybenzophenone derivatives as a yellow solid in 60% yield.
59%	With oxygen; pyrographite In xylene at 120℃; for 12h;

With manganese(IV) oxide In benzene

Reference： [1]Sun, Huayin; Zhang, Yonghui; Guo, Fengfeng; Yan, Yizhe; Wan, Changfeng; Zha, Zhenggen; Wang, Zhiyong [European Journal of Organic Chemistry, 2012, # 3, p. 480 - 483]
[2]Ming, Zong-Yao; Li, Kang-Rui; Meng, Fan-Jie; Shi, Lei; Jiang, Wen-Feng [Tetrahedron Letters, 2020, vol. 61, # 27]
[3]Sano, Yuki; Tanaka, Takanori; Hayashi, Masahiko [Chemistry Letters, 2007, vol. 36, # 12, p. 1414 - 1415]
[4]Kim, Kwang-Ok; Tae, Jinsung [Synthesis, 2005, # 3, p. 387 - 390]

29
[ 117-99-7 ]
[ 7462-74-0 ]
2-(2-benzoyl-phenoxy)-2-methyl-propionamide [ No CAS ]

Reference： [1]Organic Letters,2005,vol. 7,p. 3629 - 3631
[2]Organic Syntheses,2007,vol. 84,p. 325 - 333

30
[ 98-88-4 ]
[ 108-95-2 ]
[ 117-99-7 ]

Yield	Reaction Conditions	Operation in experiment
89%	With 1-carboxymethyl-3-methylimidazolium tetrachloroferrate In neat (no solvent) at 100℃; for 1h; Green chemistry; regioselective reaction;
	With boron trichloride

Reference： [1]Saha, Arijit; Payra, Soumen; Dutta, Dipa; Banerjee, Subhash [ChemPlusChem, 2017, vol. 82, # 8, p. 1129 - 1134]
[2]Tremont, Samuel J.; Lee, Len F.; Huang, Horng-Chih; Keller, Bradley T.; Banerjee, Shyamal C.; Both, Scott R.; Carpenter, Andrew J.; Wang, Ching-Cheng; Garland, Danny J.; Huang, Wei; Jones, Claude; Koeller, Kevin J.; Kolodziej, Steve A.; Li, James; Manning, Robert E.; Mahoney, Matthew W.; Miller, Raymond E.; Mischke, Deborah A.; Rath, Nigam P.; Fletcher, Theresa; Reinhard, Emily J.; Tollefson, Michael B.; Vernier, William F.; Wagner, Grace M.; Rapp, Steve R.; Beaudry, Judy; Glenn, Kevin; Regina, Karen; Schuh, Joe R.; Smith, Mark E.; Trivedi, Jay S.; Reitz, David B. [Journal of Medicinal Chemistry, 2005, vol. 48, # 18, p. 5837 - 5852]

31
[ 117-99-7 ]
[ 98-59-9 ]
[ 851591-22-5 ]

Yield	Reaction Conditions	Operation in experiment
99%	With pyridine at 0 - 20℃;
93%	With pyridine at 0 - 20℃;

Reference： [1]Korn, Tobias J.; Schade, Matthias A.; Wirth, Stefan; Knochel, Paul [Organic Letters, 2006, vol. 8, # 4, p. 725 - 728]
[2]Sapountzis, Ioannis; Lin, Wenwei; Kofink, Christiane C.; Despotopoulou, Christina; Knochel, Paul [Angewandte Chemie - International Edition, 2005, vol. 44, # 11, p. 1654 - 1657]

32
[ 117-99-7 ]
[ 358-23-6 ]
[ 512787-24-5 ]

Yield	Reaction Conditions	Operation in experiment
99%	With pyridine; dmap In dichloromethane at -78 - 0℃; for 1.5h;
94%	With pyridine at 0 - 20℃;
85%	With triethylamine In dichloromethane at 80℃; for 12h;

With pyridine In dichloromethane at 0 - 20℃;

Reference： [1]Location in patent: experimental part Kitamura, Mitsuru; Moriyasu, Yohei; Okauchi, Tatsuo [Synlett, 2011, # 5, p. 643 - 646]
[2]Sapountzis, Ioannis; Lin, Wenwei; Kofink, Christiane C.; Despotopoulou, Christina; Knochel, Paul [Angewandte Chemie - International Edition, 2005, vol. 44, # 11, p. 1654 - 1657]
[3]Tong, Zhou; Tang, Zhi; Au, Chak-Tong; Qiu, Renhua [Journal of Organic Chemistry, 2020, vol. 85, # 13, p. 8533 - 8543]
[4]Xu, Musheng; Lukeman, Matthew; Wan, Peter [Photochemistry and Photobiology, 2006, vol. 82, # 1, p. 50 - 56]

33
[ 117-99-7 ]
(-)-1-<(1R)-1-hydroxyphenylmethyl>-2-hydroxybenzene [ No CAS ]
(+)-1-<(1S)-1-hydroxyphenylmethyl>-2-hydroxybenzene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With potassium phosphate buffer; D-glucose; ketoreductase enzyme 111 In tetrahydrofuran; water at 30℃; for 24h; Title compound not separated from byproducts;
77 % ee	With formic acid; Ms-DENEB; triethylamine at 40℃; for 13h; Inert atmosphere; Overall yield = 94 %; Overall yield = 0.188 g; enantioselective reaction;
80 % ee	With formic acid; C₃₀H₃₂N₂O₂RuS; triethylamine for 72h; Inert atmosphere; Overall yield = 80.7 percent; Overall yield = 32.6 mg;

Reference： [1]Truppo, Matthew D.; Pollard, David; Devine, Paul [Organic Letters, 2007, vol. 9, # 2, p. 335 - 338]
[2]Touge, Taichiro; Nara, Hideki; Fujiwhara, Mitsuhiko; Kayaki, Yoshihito; Ikariya, Takao [Journal of the American Chemical Society, 2016, vol. 138, # 32, p. 10084 - 10087]
[3]Clarkson, Guy J.; Wills, Martin; Zheng, Ye [Organic Letters, 2020]

34
[ 117-99-7 ]
[ 96-32-2 ]
[ 938443-85-7 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate; sodium iodide In acetonitrile at 90℃; for 18h;	49 Intermediate 49: (2-Benzoylphenoxy)acetic acid Methyl bromoacetate (3.0ml) was added to a suspension containing 2-hydroxybenzophenone (2.3g), potassium carbonate (3.2g) and sodium iodide (2.33g) in acetonitrile (35ml).. The mixture was stirred for 18h at 90°C under a nitrogen atmosphere and was then allowed to cool to 20°C. It was then partitioned between ethyl acetate (80ml) and water (60ml) and the organic extract washed with water (2 x 60ml) and brine (60ml), dried over magnesium sulphate and evaporated in vacuo.. The crude material was purified by flash column chromatography on silica gel eluding with ethyl acetate/petroleum ether (1:1) to give a pale yellow oil (3.05g).. This was dissolved in methanol (100ml) and 1M sodium hydroxide (35ml) and the solution was stirred for 18h at 20°C. The solution was acidified to PH 1 with 2M hydrochloric acid and extracted with ethyl acetate (2 x 80ml).. The combined organic extracts were washed with water (2 x 70ml), dried over magnesium sulphate and evaporatedin vacuo.. The crude product was purified by flash column chromatography on silica gel eluding with a gradient of ethyl acetate/petroleum ether (1:1) to ethyl acetate/methanol (4:1) to give the title compound as a pale yellow gum (1.62g, 57%). LCMS: Rt 3.41 min; m/z 257 (MH+).

Reference： [1]Current Patent Assignee: GLAXOSMITHKLINE PLC - EP1140837, 2004, B1 Location in patent: Page 26

35
[ 278597-94-7 ]
[ 117-99-7 ]
[ 1026284-86-5 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate; sodium iodide In DMF (N,N-dimethyl-formamide) at 20℃; for 18h;	1 Example 1: (2S)-2-[((2S)-2-[2-(2-Benzoylphenoxy)acetyl]amino}-4-methyl pentanoyl)amino]-3-{4-[({4-[(2-phenylacetyl)amino]-1-piperidinyl}carbonyl)oxy]phenyl}propanoic acid To a solution of 2-hydroxybenzophenone (0.134g) in anhydrous DMF (0.5ml) was added anhydrous potassium carbonate (0.093g) followed by Intermediate 28 (0.152g) and sodium iodide (0.1g).. After stirring for 18h at 20°C the mixture was partitioned between saturated aqueous sodium hydrogen carbonate (10ml) and ethyl acetate (10ml).. The layers were separated and the aqueous phase was further extracted with ethyl acetate (3 x 10ml).. The combined organic extracts were washed with water (20ml) and brine (20ml), dried over sodium sulphate and evaporated in vacuo.. The crude material was purified by flash column chromatography on silica gel eluding with dichloromethane/methanol (10:1) to give a pale yellow solid.. To a solution of this in methanol (0.5ml) was added 1M sodium hydroxide (0.22ml).. After stirring for 1.5h at 20°C the mixture was partitioned between 2M hydrochloric acid (5ml) and dichloromethane (10ml).. The layers were separated and the aqueous phase was further extracted with dichloromethane (2 x 10ml).. The combined organic extracts were washed with water (20ml) and brine (20ml), dried over sodium sulphate and evaporated in vacuo to give the title compound as a pale yellow foam (0.123g, 73%). LCMS: Rt 3.84 min;m/z 775 [M-H]-.

Reference： [1]Current Patent Assignee: GLAXOSMITHKLINE PLC - EP1140837, 2004, B1 Location in patent: Page 28-29

36
[ 35654-56-9 ]
[ 117-99-7 ]
{2-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}(phenyl)-methanone hydrochloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
10%	Stage #1: 6,7-dimethoxy-4-chloroquinoline; 2-Hydroxybenzophenone at 180℃; for 1h; Stage #2: With sodium hydroxide In chloroform; water Stage #3: With hydrogenchloride In methanol	Compound 63: {2-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}(phenyl)-methanone hydrochloride Compound 63: {2-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}(phenyl)-methanone hydrochloride; 4-Chloro-6,7-dimethoxyquinoline (0.92 g) and 2-hydroxybenzophenone (1.64 g) were stirred at 180°C for one hr, and the reaction solution was cooled to room temperature. Chloroform was then added to the reaction solution, and separation was carried out with a 10% aqueous sodium hydroxide solution. The organic layer was washed with a saturated aqueous sodium hydrogencarbonate solution and saturated brine and was dried over anhydrous magnesium sulfate. The solvent was removed therefrom by distillation under the reduced pressure, and the residue was purified by column chromatography on silica gel using hexane-acetone. Thereafter, 10% hydrochloric acid-methanol (10 ml) was added to the product, followed by concentration. The concentrate was suspended in ether. The suspension was filtered to give the title compound (174 mg, yield 10%). 1H-NMR (CDCl3, 400 MHz): δ 3.92 (s, 3H), 4.13 (s, 3H), 6.66 (d, J = 6.4 Hz, 1H), 7.15 (s, 1H), 7.35 - 7.41 (m, 3H), 7.52 - 7.61 (m, 2H), 7.67 - 7.79 (m, 4H), 8.08 (s, 1H), 8.44 (dd, J = 6.6 Hz, 6.6 Hz, 1H) Mass spectrometric value (ESI-MS, m/z): 386 (M-HCl+1)+

Reference： [1]Current Patent Assignee: KIRIN HOLDINGS CO., LTD.; Kyowa Kirin (in: Kirin Holdings) - EP1548008, 2005, A1 Location in patent: Page/Page column 77

37
[ 117-99-7 ]
[ 182499-95-2 ]

Yield	Reaction Conditions	Operation in experiment
44%	With sodium nitrate; sulfuric acid In dichloromethane	96.a a) a) Preparation of 3-nitro-2-hydroxybenzophenone 2-Hydroxybenzophenone (3.00 g, 15.1 mmol) was dissolved in methylene chloride(40 mL) followed by the addition of sodium nitrate (1.42 g, 16.7 mmol). The addition of sulfuric acid (25 mL/3M) was then made, followed by addition of a catalytic amount of sodium nitrite. The mixture was allowed to stir. After 24 hours, the reaction mixture was diluted with methylene chloride and extracted with water. The organic layer was dried over MgSO4 and filtered. The solvent was evaporated and chromatography of the resulting solid on silica gel (4% MeOH/CH2 Cl2) gave the desired product(1.60 g, 44%). 1 H NMR (CD3COCD3): δ 8.30 (d, 1H), 7.86 (m, 3H), 7.71 (m, 1H), 7.78 (d, 1H), 7.56 (dd 2H), 7.24 (t, 1H).
44%	With sodium nitrate; sulfuric acid In dichloromethane	96 a)Preparation of 3-nitro-2-hydroxybenzophenone a)Preparation of 3-nitro-2-hydroxybenzophenone 2-Hydroxybenzophenone (3.00 g, 15.1 mmol) was dissolved in methylene chloride(40 mL) followed by the addition of sodium nitrate (1.42 g, 16.7 mmol). The addition of sulfuric acid (25 mL/3M) was then made, followed by addition of a catalytic amount of sodium nitrite. The mixture was allowed to stir. After 24 hours, the reaction mixture was diluted with methylene chloride and extracted with water. The organic layer was dried over MgSO4 and filtered. The solvent was evaporated and chromatography of the resulting solid on silica gel (4%MeOH/CH2 Cl2) gave the desired product(1.60 g, 44%). 1 H NMR (CD3COCD3): d 8.30 (d,1H), 7.86 (m,3H), 7.71 (m, 1H), 7.78 (d, 1H), 7.56 (dd 2H), 7.24 (t, 1H).
44%	With sodium nitrate; sulfuric acid In dichloromethane	96 a)Preparation of 3-nitro-2-hydroxybenzophenone a)Preparation of 3-nitro-2-hydroxybenzophenone 2-Hydroxybenzophenone (3.00 g, 15.1 mmol) was dissolved in methylene chloride (40 mL) followed by the addition of sodium nitrate (1.42 g, 16.7 mmol). The addition of sulfuric acid (25 mL/3M) was then made, followed by addition of a catalytic amount of sodium nitrite. The mixture was allowed to stir. After 24 hours, the reaction mixture was diluted with methylene chloride and extracted with water. The organic layer was dried over MgSO4 and filtered. The solvent was evaporated and chromatography of the resulting solid on silica gel (4%MeOH/CH2CH2) gave the desired product (1.60 g, 44%). 1H NMR (CD3COCD3): d 8.30 (d, 1H), 7.86 (m, 3H), 7.71 (m, 1H), 7.78 (d, 1H), 7.56 (dd 2H), 7.24 (t, 1H).

Reference： [1]Current Patent Assignee: GLAXOSMITHKLINE PLC - US5886044, 1999, A
[2]Current Patent Assignee: GLAXOSMITHKLINE PLC - US5780483, 1998, A
[3]Current Patent Assignee: GLAXOSMITHKLINE PLC - US6262113, 2001, B1

38
(R)-α-MeHA dihydromaleate [ No CAS ]
[ 117-99-7 ]
[ 139191-80-3 ]

Yield	Reaction Conditions	Operation in experiment
63.7%	With potassium <i>tert</i>-butylate In ethanol; isopropyl alcohol	Preparation of (R)-(-)-2-[N-[1-(1H-imidazol-4-yl)-2-propyl]-(iminophenylmethyl)]phenol (No. 94) from (R)-α-MeHA dihydromaleate Preparation of (R)-(-)-2-[N-[1-(1H-imidazol-4-yl)-2-propyl]-(iminophenylmethyl)]phenol (No. 94) from (R)-α-MeHA dihydromaleate 2.24 g (20 mmol) of potassium tert-butoxide are dissolved in 30 ml of anhydrous 2-propanol. After adding 1.79 g (5 mmol) of (R)-α-MeHA dihydromaleate, the suspension obtained is stirred overnight. The material which separates off (disodium maleate) is separated by filtration and washed twice with 5 ml of anhydrous 2-propanol. The combined filtrates are evaporated to dryness and redissolved in 40 ml of anhydrous ethanol. After adding 1.19 g (6 mmol) of 2-hydroxybenzophenone, the solution is refluxed for 15 min and evaporated to dryness. Diethyl ether and a few seed crystals are added to the oil obtained and the mixture is stirred for the crystallization. The yellow material obtained is recrystallized twice from cyclohexane/anhydrous ethyl acetate. Yield 63.7% m.p.: 142°-144° C. (cyclohexane/EtOAc) C19 H19 N3 O (305.4) calculated C 74.73 H 6.27 N 13.76 found C 74.43 H 6.33 N 13.79. 1 H NMR: [D6]DMSO (300 MHz) δ=15.63 (s, replaceable by D2 O, 1H, Im-NH), 11.73 (br, replaceable by D2 O, 1H, OH), 5.51-6.54 (m, 11H, atom), 3.53 (dt, J1 =J2 =6Hz, 1H, CH--CH2), 2.73 (d, J=6Hz, 2H, CH2), 1.15 (d, J=6Hz, 3H, CH3), ppm rel. TMS, MS: EI m/z (rel.int.[%]) 305 ([M]+, 6), 224 (43), 172 (72), 171 (44), 144 (34), 118 (51), 89 (40), 69 (86), 41 (100). IR: 3076 m, 2966 m, 2600 ns, 1961 s, 1606 s, 1571 cm-1. [α]D20 =-295.4° (MeOH, c=1).

Reference： [1]Current Patent Assignee: BIOPROJET; SOCIETE CIVILE BIOPROJET; NATIONAL INSTITUTE OF HEALTH AND MEDICAL RESEARCH - US5342960, 1994, A

39
[ 117-99-7 ]
[ 74-86-2 ]
[ 1005328-49-3 ]

Yield	Reaction Conditions	Operation in experiment
88%	Stage #1: acetylene With ethylmagnesium bromide In tetrahydrofuran at 20℃; for 3.5h; Stage #2: 2-Hydroxybenzophenone In tetrahydrofuran at 0 - 20℃; for 16h; Further stages.;

Reference： [1]Gabriele, Bartolo; Mancuso, Raffaella; Salerno, Giuseppe; Plastina, Pierluigi [Journal of Organic Chemistry, 2008, vol. 73, # 2, p. 756 - 759]

40
[ 117-99-7 ]
[ 88284-48-4 ]
[ 596-38-3 ]

Yield	Reaction Conditions	Operation in experiment
82%	With cesium fluoride In acetonitrile at 20℃; for 12h;

Reference： [1]Okuma, Kentaro; Nojima, Akiko; Matsunaga, Nahoko; Shioji, Kosei [Organic Letters, 2009, vol. 11, # 1, p. 169 - 171]

41
[ 119-61-9 ]
[ 117-99-7 ]
[ 13020-57-0 ]

Reference： [1]Chemical Communications,2009,p. 7191 - 7193

42
[ 117-99-7 ]
[ 106-96-7 ]
[ 18296-78-1 ]

Yield	Reaction Conditions	Operation in experiment
99%	With caesium carbonate In acetonitrile at 50℃; Inert atmosphere;
98%	With caesium carbonate In acetonitrile at 80℃; for 18h;
89.7%	With potassium carbonate In acetone for 18h; Inert atmosphere; Reflux;

Reference： [1]Lamb, Kellan N.; Squitieri, Richard A.; Chintala, Srinivasa R.; Kwong, Ada J.; Balmond, Edward I.; Soldi, Cristian; Dmitrenko, Olga; Castiñeira Reis, Marta; Chung, Ryan; Addison, J. Bennett; Fettinger, James C.; Hein, Jason E.; Tantillo, Dean J.; Fox, Joseph M.; Shaw, Jared T. [Chemistry - A European Journal, 2017, vol. 23, # 49, p. 11843 - 11855]
[2]Dimirjian, Christine A.; Castiñeira Reis, Marta; Balmond, Edward I.; Turman, Nolan C.; Rodriguez, Elys P.; Di Maso, Michael J.; Fettinger, James C.; Tantillo, Dean J.; Shaw, Jared T. [Organic Letters, 2019, vol. 21, # 18, p. 7209 - 7212]
[3]Location in patent: experimental part Schuh, Esther; Valiahdi, Seied M.; Jakupec, Michael A.; Keppler, Bernhard K.; Chiba, Peter; Mohr, Fabian [Dalton Transactions, 2009, # 48, p. 10841 - 10845]

43
[ 5663-67-2 ]
[ 98-80-6 ]
[ 117-99-7 ]

Yield	Reaction Conditions	Operation in experiment
55%	With oxygen; potassium carbonate; palladium(II) chloride benzonitrile complex; copper dichloride In N,N-dimethyl-formamide at 60℃; for 9h;

Reference： [1]Weng, Fei; Wang, Chengming; Xu, Bin [Tetrahedron Letters, 2010, vol. 51, # 19, p. 2593 - 2596]

44
[ 90-02-8 ]
[ 98-80-6 ]
[ 117-99-7 ]

Yield	Reaction Conditions	Operation in experiment
98%	With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper diacetate In N,N-dimethyl-formamide at 80℃; for 8h; Sealed tube;	General procedure: A mixture of salicylaldehyde (0.2 mmol) and arylboronic acid (0.4 mmol) was dissolved in DMF (2 mL) and [Cp*RhCl2]2 (4.9 mg,4 mol %) and Cu(OAc)2 (72.8 mg, 0.4 mmol) was added. Then the reaction was conducted in a sealed tube at a temperature of 80 C for 8 h. The reaction mixture was diluted with ethylacetate (20 mL),washed with H2O (310 mL). The organic layer was then dried over anhydrous Na2SO4, filtered and concentrate. The crude product was loaded on a silica gel column and flashed with 5-10% ethyl acetate in petroleum ether to afford the desired products 3 as solid or liquid
90%	With pyridine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; copper(I) bromide In tert-Amyl alcohol at 130℃; for 12h; Sealed tube;
85%	With oxygen; sodium hydrogencarbonate; palladium(II) chloride benzonitrile complex; copper dichloride In N,N-dimethyl-formamide at 60℃; for 8h;

Reference： [1]Wang, Dahai; Cui, Sunliang [Tetrahedron, 2015, vol. 71, # 45, p. 8511 - 8516]
[2]Xiao, Lin; Lang, Tao-Tao; Jiang, Ying; Zang, Zhong-Lin; Zhou, Cheng-He; Cai, Gui-Xin [Chemistry - A European Journal, 2021, vol. 27, # 10, p. 3278 - 3283]
[3]Weng, Fei; Wang, Chengming; Xu, Bin [Tetrahedron Letters, 2010, vol. 51, # 19, p. 2593 - 2596]

45
[ 117-99-7 ]
[ 105-53-3 ]
ethyl 2-oxo-4-phenyl-2H-1-benzopyran-3-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
91%	With zirconyl chloride octahydrate; sodium amide In tetrahydrofuran at 25℃; for 0.5h; Green chemistry;	General procedure for the synthesis of chromen-2-one derivatives from salicylaldehydes and active methylene compounds (3a-m) General procedure: A mixture of salicylaldehyde (1, 1 mmol), active methylene compound (2, 1.2 mmol), ZrOCl2-THF (0.048 g, 0.15 mmol) and sodium amide (0.005 g, 0.15 mmol) was stirred for 30 min at room temperature. The progress of the reaction was monitored by TLC. After the completion of reaction, the crude mixture was diluted with moist ether (20 mL). The resultant reaction mixture was washed with water (3 × 25 mL) to discharge the colour, ZrOCl2 and sodium amide. The ethereal solution obtained after extraction was dried over anhydrous Na2SO4 and evaporated under reduced pressure. Finally, this reaction mixture was purified by passing through a silica gel column chromatography to get pure product (Scheme-I).
69%	With 1,8-diazabicyclo[5.4.0]undec-7-ene at 160℃; for 8h; Sealed tube;
44%	With potassium <i>tert</i>-butylate at 90℃; for 0.25h; Microwave irradiation; Neat (no solvent);

Reference： [1]TASQEERUDDIN; ASIRI, YAHYA I.; SHAHEEN [Asian Journal of Chemistry, 2020, vol. 32, # 10, p. 2611 - 2616]
[2]Zhao, Qian-Kun; Wu, Xiong; Yang, Fan; Yan, Pu-Cha; Xie, Jian-Hua; Zhou, Qi-Lin [Organic Letters, 2021, vol. 23, # 9, p. 3593 - 3598]
[3]Location in patent: scheme or table Crecente-Campo, Jose; Vazquez-Tato, M. Pilar; Seijas, Julio A. [European Journal of Organic Chemistry, 2010, # 21, p. 4130 - 4135]

46
[ 117-99-7 ]
[ 56613-80-0 ]
[ 1309575-86-7 ]

Yield	Reaction Conditions	Operation in experiment
92%	In ethanol for 1h; Reflux;	General method for the preparation of tridentate ligands 3b and 3g General Procedure: In order to prepare the tridentate ligands 3b and 3g, equimolar quantities of the corresponding aminoalcohol and 2-hydroxybenzophenone or 2-hydroxyacetophenone, respectively, were refluxed in ethanol for 1 h. The solvent and the water formed during the reaction were eliminated to yield yellow solids which were washed with methylene chloride and used without further purification. Tridentate ligands 3a, 3c, 3d, 3e, 3f, 3h and 3i have already been published.

Reference： [1]Location in patent: experimental part Rivera, José María; Rincón, Susana; Farfán, Norberto; Santillan, Rosa [Journal of Organometallic Chemistry, 2011, vol. 696, # 11-12, p. 2420 - 2428]

47
[ 117-99-7 ]
[ 108-24-7 ]
[ 15185-05-4 ]

Yield	Reaction Conditions	Operation in experiment
91%	With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 80℃; for 8h;
86%	With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 90℃; for 8h;
86%	With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20℃; for 8h;

Reference： [1]Tong, Zhou; Tang, Zhi; Au, Chak-Tong; Qiu, Renhua [Journal of Organic Chemistry, 2020, vol. 85, # 13, p. 8533 - 8543]
[2]Location in patent: experimental part Hwang, In-Taek; Lee, Sun-Ah; Hwang, Jin-Soo; Lee, Kee-In [Molecules, 2011, vol. 16, # 8, p. 6313 - 6321]
[3]Cao, Xiao-Hui; Pan, Xiangqiang; Zhou, Peng-Jun; Zou, Jian-Ping; Asekun, Olayinka Taiwo [Chemical Communications, 2014, vol. 50, # 25, p. 3359 - 3362]

48
[ 468075-00-5 ]
[ 117-99-7 ]
[ 1331753-59-3 ]