630-580-1088 sales@ambeed.com
Structure Search

List Search MOL Search Structure Search

0
Chemistry
Asymmetric Synthesis >>Chiral Building BlocksChiral Catalysts, Chiral Ligands and Chiral ReagentsChiral Resolution ReagentsBoronic acids/esters >>Aliphatic BoronsAromatic BoronsOther BoronsOxaborolesCatalysis Chemistry >>Achiral Crown LigandsC-H ActivationCarbon-Donor LigandsChiral Carbon LigandsChiral Crown LigandsChiral Olefin LigandsCross-CouplingCross-Coupling Using Transition Metal CatalystsDACH or Trost LigandsChemical Biology >>Conjugation Chemistry
GlycoscienceLinkers and CrosslinkersNucleic Acid ChemistryPEGylationPeptide ChemistryPhotolabile Protecting GroupHeterocyclic Building Blocks >>AcridinesAliphatic HeterocyclesAromatic HeterocyclesAzetidinesBenzimidazolesBenzisoxazolesBenzodioxansBenzofuransBenzothiazolesInorganic reagents >>Inorganic reagentOrganic Building Blocks >>Acid AnhydridesAcyl Chlorides
AlcoholsAldehydesAliphatic Chain HydrocarbonsAliphatic Cyclic HydrocarbonsAlkenesAlkylsAlkynesOrganometallic Reagents >>Grignard ReagentsOrganoarsenicOrganobismuthOrganoboronOrganogermaniumOrganolithiumOrganomercuryOrganosiliconOrganotinSpecialty Synthesis >>Enzyme-Mediated SynthesisFluorous SynthesisIonic Liquids
Solid Supported SynthesisStains and Dyes >>Acid DyesAzoic DyesBasic DyesDirect DyesDisperse DyesDye IntermediatesMordant DyesOil DyesOther Stains and DyesSynthetic Reagents >>Acids and BasesC-C Bond FormationC-X Bond Formation (Halogen)C-X Bond Formation (Non-Halogen)Chelation and Complexation CompoundsCondensation AgentsCouplingDehydrating ReagentsFluorination Reagent
Pharmaceutical Intermediates
Analgesics >>BenzhydrocodoneBicifadineCapsaicinCelecoxibDebio-0827DexamethasoneElagolix SodiumEsketamine HydrochlorideIbuprofen sodiumAnesthetics >>CiprofolEsketamine HydrochlorideFospropofol Fospropofol DisodiumLevobupivacaine RemimazolamRemimazolam BesilateRemimazolam besylateRopivacaineAnti-Addiction Agents >>Kakonein
Lofexidine HydrochlorideVarenicline Anti-inflammatory Agents >>ApremilastAsunaprevirATB-346 RelatedBalsalazide BaricitinibBencycloquidium BromideBudesonideCefiderocol Sulfate TosylateCeftaroline Fosamil AcetateAntibacterials >>AFN-1252 RelatedAlatrofloxacin Bedaquiline FumarateBesifloxacin BrilacidinCaspofungin AcetateCefiderocol Sulfate TosylateCefilavancinCeftaroline Fosamil
Anticonvulsants >>BrivaracetamCannabidiolEscitalopram OxalateEslicarbazepine Acetate RelatedFosphenytoinGabapentin EnacarbilJNJ-10234094LacosamideLevetiracetam RelatedAntidementia Agents >>Azeliragon RelatedDavunetideDonepezil HydrochlorideDonepezil RelatedEnsaculinFlorbetaben Flortaucipir F 18Flutemetamol IdalopirdineAntidepressants >>4-Chlorokynurenine
AgomelatineAgomelatine RelatedAllopregnanolone RelatedAmibegronAmitifadineAripiprazole RelatedBasimglurantBefloxatoneAntiemetics >>AprepitantAprepitant RelatedDolasetron RelatedDolasetron Mesylate HydrateFosaprepitant DimeglumineFosaprepitant RelatedOlanzapinePalonosetron RelatedPalonosetron HydrochlorideAntifungals >>Anidulafungin RelatedCabotegravirMore >>
Inhibitors/Agonists
ADC >>ADC AntibodyADC LinkerADC Linker with PayloadADC ToxinAntibody-Drug Conjugates (ADCs)Drug-Linker Conjugates for ADCAngiogenesis >>ALKBcr-AblBTKEGFRFAKFGFRFLT3HER2HIFAnti-infection >>3CLproAntibacterialAntibioticAntifungal
AntiparasiticAntiprotozoalAntiviralArenavirusBVDVApoptosis >>Apoptosis InducerBcl-2Bcl-6BRKc-Mycc-RETC/EBPCARDCaspaseAutophagy >>Atg4ATG4BATTECsAUTACsAutophagyBeclin1
FKBPLC3LRRK2Biochemical Reagent >>Cell Cycle >>AntifolateAPCAurora KinaseBUBCasein KinaseCdc25CDKChkCRISPR/Cas9Cytoskeleton >>ActinArp2/3 ComplexCYTHCytoplasmic dyneinDynaminFAKMore >>
Material Science
Aggregation-Induced Emission >>Other AIE BlocksTetraphenylethylene SeriesCOFs Linkers >>Aldehyde COFs LinkersAlkynyl COFs LinkersAmine COFs LinkersBoric COFs LinkersCyano COFs LinkersMultifunctional COFs linkersOther COFs linkersTriphene seriesElectronic Materials >>Battery MaterialsDye-Sensitized Solar Cell (DSSC) MaterialsElectronic MaterialLiquid Crystal (LC) MaterialsMolecular ConductorsOrganic Light-Emitting Diode (OLED) MaterialsOrganic Solar Cell (OPV) MaterialsOrganic Transistor (OFET) MaterialsPerovskite Solar Cell (PSC) MaterialsMagnetic Materials >>Magnetic Ionic LiquidsMagnetic MaterialMagnetic Metal Complexes
Organic Radicals Material Chemical Compounds >>Ligands for Functional Metal ComplexesLiquid Crystal (LC) Building BlocksPhthalocyanine Building BlocksPolymer and Macromolecule Semiconductor Building BlocksSmall Molecule Semiconductor Building BlocksSolubility Enhancing Reagents Supramolecular Host Materials MOF Ligands >>Carboxylic Acid MOF LigandsCarboxylic Acid Nitrogen-Containing Mixed MOF LigandsNitrogen-Containing MOF LigandsOther MOF ligandsNanomaterials >>Carbon NanomaterialsCeramic MembranesDendrimersGold NanoparticlesIron Oxide NanoparticlesMaterials by ApplicationMesoporous MaterialsMetals and Metal AlloysNano Minerals: NanoclaysOLED Materials >>Dopant
HostHTMOLED IntermediatesOther OLED related materialsOptical Materials >>Coumarin DyesCyanine and Squarylium DyesDCM DyesDipyrromethene DyesFluorescence MaterialsFluorescent ProbesHeat and Pressure Sensitive DyesNear-Infrared (NIR) DyesOrganic Non-Linear Optical (NLO) MaterialsOrganic Pigments >>Organic PigmentOther Materials >>Mateial OtherPolymer Science >>MonomersPolymer AdditivesPolymerization ReagentsPolymersResins
Contact Us
Home Cart 0 Sign in  
Chemistry
Heterocyclic Building Blocks
Pyridines
tert-Butyl 6-bromo-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indole-2-carboxylate
Chemistry
Heterocyclic Building Blocks
Organic Building Blocks
Pyridines
Indoles Esters Aliphatic Heterocycles Carbamates

[ CAS No. 1173155-59-3 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 1173155-59-3
Chemical Structure| 1173155-59-3
Structure of 1173155-59-3 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

For Research Only 110K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 1173155-59-3 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 1173155-59-3 ]

SDS Specification
Alternatived Products of [ 1173155-59-3 ]

Product Details of [ 1173155-59-3 ]

CAS No. :1173155-59-3 MDL No. :MFCD28952870
Formula : C16H19BrN2O2 Boiling Point : -
Linear Structure Formula :- InChI Key :DDUJJQUROUAQCF-UHFFFAOYSA-N
M.W : 351.24 Pubchem ID :57950460
Synonyms :

Safety of [ 1173155-59-3 ]

Signal Word:Warning Class:
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 UN#:
Hazard Statements:H315-H319 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 1173155-59-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1173155-59-3 ]

[ 1173155-59-3 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 1173155-59-3 ]
  • [ 74-88-4 ]
  • [ 1173155-60-6 ]
YieldReaction ConditionsOperation in experiment
36% Stage #1: tert-butyl 6-bromo-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate With sodium hydride In N,N-dimethyl-formamide for 1h; Stage #2: methyl iodide In N,N-dimethyl-formamide for 0.5h; 46.d tert-Butyl 6-bromo-3,4-dihydro-lH-pyrido[3,4-6]indole-2(9H)-carboxylate (1.15 g, 3.26 mmol) was dissolved in DMF (20 mL) and sodium hydride (60% weight dispersion in mineral oil, 196 mg, 4.89 mmol) was added. After 1 h, methyl iodide (0.30 mL, 4.9 mmol) was added and the reaction mixture was stirred for a further 30 min. The mixture was diluted with methylene chloride and washed with 5% lithium chloride solution (5χ), dried Attorney's Docket 2882.023B over Na2SO4 and concentrated. Purification by flash column chromatography (silica gel, hexanes/ethyl acetate, 97:3 to 75:25) gave the title compound (740 mg, 36%) as a yellow solid: 1H NMR (500 MHz, CDCl3) δ 7.58 (s, IH), 7.24 (d overlapped by solvent, J= 8.5, IH), 7.14 (d, J= 8.5, IH), 4.67-4.53 (br m, 2H), 3.79-3.67 (br m, 2H), 3.60 (s, 3H), 2.78- 2.66 (br m, 2H), 1.51 (s, 9H).
Reference： [1]Current Patent Assignee: HARMONY BIOSCIENCES - WO2009/89482, 2009, A1 Location in patent: Page/Page column 100-101
  • 2
  • [ 24424-99-5 ]
  • [ 23046-69-7 ]
  • [ 1173155-59-3 ]
YieldReaction ConditionsOperation in experiment
30% In tetrahydrofuran; dichloromethane for 2.5h; 46.c 6-Bromo-2,3,4,9-tetrahydro-lH-pyrido[3,4-δ]indole (2.6 g, 10 mmol) was suspended in CH2Cl2 (50 mL) and THF (7.5 mL) and BoC2O (2.3 g, 11 mmol) was added. After 2.5 h, the mixture was concentrated. Purification by flash column chromatography (silica gel, hexanes/ethyl acetate, 97:3 to 70:30) gave the title compound (1.15 g, 30%) as an orange powder: 1H NMR (300 MHz, CDCl3) δ 7.59 (s, IH), 7.23 (d, J= 8.5 Hz, IH), 7.18 (d, J= 8.5 Hz, IH), 4.68-4.59 (br m, 2H), 3.80-3.70 (br m, 2H), 2.78-2.71 (br m, 2H), 1.50 (s, 9H).
Reference： [1]Current Patent Assignee: HARMONY BIOSCIENCES - WO2009/89482, 2009, A1 Location in patent: Page/Page column 100
  • 3
  • [ 1173155-59-3 ]
  • [ 27983-04-6 ]
  • C25H28BrClN2O3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Stage #1: tert-butyl 6-bromo-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.583333h; Cooling with ice; Stage #2: 1-(3-bromopropoxy)-4-chlorobenzene In N,N-dimethyl-formamide at 20℃; for 1h;
Reference： [1]Tu, Jie; Li, Zhuang; Jiang, Yanjuan; Ji, Changjin; Han, Guiyan; Wang, Yan; Liu, Na; Sheng, Chunquan [Journal of Medicinal Chemistry, 2019, vol. 62, # 5, p. 2376 - 2389]
  • 4
  • [ 1173155-59-3 ]
  • [ 203071-48-1 ]
  • C28H33BrN2O5 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Stage #1: tert-butyl 6-bromo-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 0.583333h; Stage #2: methyl 2-(4-(3-bromopropoxy)phenyl)acetate In N,N-dimethyl-formamide at 20℃; for 1h;
Reference： [1]Li, Zhuang; Tu, Jie; Han, Guiyan; Liu, Na; Sheng, Chunquan [Journal of Medicinal Chemistry, 2021, vol. 64, # 2, p. 1116 - 1126]

Tags: 1173155-59-3 synthesis path| 1173155-59-3 SDS| 1173155-59-3 COA| 1173155-59-3 purity| 1173155-59-3 application| 1173155-59-3 NMR| 1173155-59-3 COA| 1173155-59-3 structure

Same Skeleton Products
Related Products
Historical Records