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Chemical Structure| 1174428-30-8 Chemical Structure| 1174428-30-8

Structure of 1174428-30-8

Chemical Structure| 1174428-30-8

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Product Details of [ 1174428-30-8 ]

CAS No. :1174428-30-8
Formula : C17H16N2O3S
M.W : 328.39
SMILES Code : O=C1C2=C(C(C3=CC=CC(N)=C3)=CS2)OC(N4CCOCC4)=C1
MDL No. :N/A

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Application In Synthesis of [ 1174428-30-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1174428-30-8 ]

[ 1174428-30-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 6608-47-5 ]
  • [ 1174428-30-8 ]
  • 5-morpholino-3-[m-(vinylsulfonylamino)phenyl]-4-oxa-1-thia-7-indenone [ No CAS ]
  • C21H20N2O7S3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
4%; 11% With triethylamine; In dichloromethane; at -78 - 0℃; for 1h;Inert atmosphere; 3-(m-Aminophenyl)-5-morpholino-4-oxa-l-thia-7-indenone (1.68 g, 5.13 mmol) andtriethylamine (1.8 mL, 12.83 mmol) were dissolved in dichloromethane (1.8 mL) and the resulting mixture was cooled -78C, under nitrogen with vigorous stirring. To this mixture, ethene sulphonyl chloride (650 mg, 5.13 mmol) was added dropwise in two to three minutes. The resulting mixture was stirred for an additional hour at -78C and then warmed to 0C and kept at that temperature for one hour. The reaction was then immediately quenched with 1 mL of water and diluted with dichloromethane (50 mL). The organic layer was washed with water, dried (Na2S04), filtered and concentrated to yield the crude sulfonamide. This material was purified on silica gel column chromatography using 0-15% acetone/ dichloromethane twice. The faster moving compound was isolated as the disulfonamide, Compound II-6 (274 mg, 11%).LC/MS: Peak at 2.45 min 509.3 (m/z). Purity: 99.5 %. The disulfonamide was assigned Compound II-6.The slower moving compound was the desired mono sulfonamide Compound 11-18 (75 mg, 4% yield).LC/MS: Peak at 2.28 min 419.4 (m/z), Purity: 99.5%.
 

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