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Chemical Structure| 1174534-36-1 Chemical Structure| 1174534-36-1

Structure of 1174534-36-1

Chemical Structure| 1174534-36-1

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Product Details of [ 1174534-36-1 ]

CAS No. :1174534-36-1
Formula : C7H8N2O3S
M.W : 200.22
SMILES Code : O=C(C1=CN=C(NC(C)=O)S1)OC
MDL No. :MFCD17015003

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Application In Synthesis of [ 1174534-36-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1174534-36-1 ]

[ 1174534-36-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 6633-61-0 ]
  • [ 108-24-7 ]
  • [ 1174534-36-1 ]
YieldReaction ConditionsOperation in experiment
90% With triethylamine; In tetrahydrofuran; Preparation 6[0046] Methyl 2-acetamidothiazole-5-carboxylateMethyl 2-aminothiazole-5-carboxylate, 1.58 g, 10 mmol, was added to a 50 mL, 3-necked round-bottomed flask fitted with a mechanical agitator. Tetrahydrofuran, 15 mL, was added followed by triethylamine, 2.1 mL, 1.5 eq. Acetic anhydride, 1.3 mL, 1.4 eq., was added. After stirring overnight, 20 mL of water and 5 mL of methanol was added and the mixture was stirred at ambient temperature for two hours. The product was isolated by filtration, was rinsed with aqueous methanol and then water. Drying in the air provided 1.81 g, 90%, of an off-white solid, LC/MS: 201.1; NMR: 12.6 (s, 1H), 8.15 (s, 1H), 3.81 (s, 3H), 2.19 (s, 3H); HPLC: RT 5.83 min, 99.5%.
 

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