1181573-42-1|tert-butyl (1R,3S,4S)-3-(aminomethyl)-2-azabicyclo[2.2.1]heptane-2-carboxylate| Ambeed

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Yield	Reaction Conditions	Operation in experiment
		B.2 Synthesis of (lR^S^SJ-S-Acylaminomethyl-l-aza-bicyclobeta.l.ljheptane derivatives; B.2.1 Synthesis of (lR^S^SJ-S-Acylaminomethyl^-aza-bicyclobetaJ.llheptane^- carboxylic acid tert-butyl ester derivatives; (general procedure); TBTU (0.73 mmol, 1.1 Oeq) is added to a solution of the respective carboxylic acid (0.70 mmol, 1.05eq) and DIPEA (1.66 mmol, 2.5eq) in DCM (1.0 mL) and DMF (0.25 mL). After 10 min a solution of (lR,3S,4S)-3-aminomethyl-2-aza-bicyclo[2.2.1]heptane-2- carboxylic acid tert-butyl ester (0.66 mmol, l.Oeq) in DCM (1.0 mL) is added and the mixture is stirred for 2h and washed twice with water (1.0 mL). The organic layer is dried over MgSO4, the solvents are removed in vacuo and the residue is purified by prep. HPLC to give the respective amide.; (lR,3S,4S)-3-[(Benzofuran-4-carbonyl)-amino]-methyl}-2-aza-bicyclo[2.2.1]heptane- 2-carboxylic acid tert-butyl ester prepared by reaction of (lR,3S,4S)-3-aminomethyl-2-aza-bicyclo[2.2.1]heptane-2- carboxylic acid tert-butyl ester with <strong>[166599-84-4]benzofuran-4-carboxylic acid</strong> (M.A. Eissenstat et al. J. Med. Chem. 1995, 38, 3094-3105). LC-MS (basic): tR = 0.97 min; [M+H]+ = 371.1.

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Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

CAS No. :	1181573-42-1	MDL No. :
Formula :	C₁₂H₂₂N₂O₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	226.32	Pubchem ID :	-
Synonyms :

Signal Word:		Class:
Precautionary Statements:		UN#:
Hazard Statements:		Packing Group:

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[ 1181573-42-1 ] Synthesis Path-Downstream 1~1

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