630-580-1088 sales@ambeed.com
Structure Search

List Search MOL Search Structure Search

0
Chemistry
Asymmetric Synthesis >>Chiral Building BlocksChiral Catalysts, Chiral Ligands and Chiral ReagentsChiral Resolution ReagentsBoronic acids/esters >>Aliphatic BoronsAromatic BoronsOther BoronsOxaborolesCatalysis Chemistry >>Achiral Crown LigandsC-H ActivationCarbon-Donor LigandsChiral Carbon LigandsChiral Crown LigandsChiral Olefin LigandsCross-CouplingCross-Coupling Using Transition Metal CatalystsDACH or Trost LigandsChemical Biology >>Conjugation Chemistry
GlycoscienceLinkers and CrosslinkersNucleic Acid ChemistryPEGylationPeptide ChemistryPhotolabile Protecting GroupHeterocyclic Building Blocks >>AcridinesAliphatic HeterocyclesAromatic HeterocyclesAzetidinesBenzimidazolesBenzisoxazolesBenzodioxansBenzofuransBenzothiazolesInorganic reagents >>Inorganic ReagentOrganic Building Blocks >>Acid AnhydridesAcyl Chlorides
AlcoholsAldehydesAliphatic Chain HydrocarbonsAliphatic Cyclic HydrocarbonsAlkenesAlkylsAlkynesOrganometallic Reagents >>Grignard ReagentsOrganoarsenicOrganobismuthOrganoboronOrganogermaniumOrganolithiumOrganomercuryOrganosiliconOrganotinSpecialty Synthesis >>Enzyme-Mediated SynthesisFluorous SynthesisIonic Liquids
Solid Supported SynthesisStains and Dyes >>Acid DyesAzoic DyesBasic DyesDirect DyesDisperse DyesDye IntermediatesMordant DyesOil DyesOther Stains and DyesSynthetic Reagents >>Acids and BasesC-C Bond FormationC-X Bond Formation (Halogen)C-X Bond Formation (Non-Halogen)Chelation and Complexation CompoundsCondensation AgentsCouplingDehydrating ReagentsFluorination Reagent
Pharmaceutical Intermediates
Analgesics >>BenzhydrocodoneBicifadineCapsaicinCelecoxibDebio-0827DexamethasoneElagolix SodiumEsketamine HydrochlorideIbuprofen SodiumAnesthetics >>CiprofolEsketamine HydrochlorideFospropofol Fospropofol DisodiumLevobupivacaine RemimazolamRemimazolam BesilateRemimazolam BesylateRopivacaineAnti-Addiction Agents >>Kakonein
Lofexidine HydrochlorideVarenicline Anti-inflammatory Agents >>ApremilastAsunaprevirATB-346 RelatedBalsalazide BaricitinibBencycloquidium BromideBudesonideCefiderocol Sulfate TosylateCeftaroline Fosamil AcetateAntibacterials >>AFN-1252 RelatedAlatrofloxacin Bedaquiline FumarateBesifloxacin BrilacidinCaspofungin AcetateCefiderocol Sulfate TosylateCefilavancinCeftaroline Fosamil
Anticonvulsants >>BrivaracetamCannabidiolEscitalopram OxalateEslicarbazepine Acetate RelatedFosphenytoinGabapentin EnacarbilJNJ-10234094LacosamideLevetiracetam RelatedAntidementia Agents >>Azeliragon RelatedDavunetideDonepezil HydrochlorideDonepezil RelatedEnsaculinFlorbetaben Flortaucipir F 18Flutemetamol IdalopirdineAntidepressants >>4-Chlorokynurenine
AgomelatineAgomelatine RelatedAllopregnanolone RelatedAmibegronAmitifadineAripiprazole RelatedBasimglurantBefloxatoneAntiemetics >>AprepitantAprepitant RelatedDolasetron RelatedDolasetron Mesylate HydrateFosaprepitant DimeglumineFosaprepitant RelatedOlanzapinePalonosetron RelatedPalonosetron HydrochlorideAntifungals >>Anidulafungin RelatedCabotegravirMore >>
Inhibitors/Agonists
ADC >>ADC AntibodyADC LinkerADC Linker with PayloadADC ToxinAntibody-Drug Conjugates (ADCs)Drug-Linker Conjugates for ADCAngiogenesis >>ALKBcr-AblBTKEGFRFAKFGFRFLT3HER2HIFAnti-infection >>3CLproAntibacterialAntibioticAntifungal
AntiparasiticAntiprotozoalAntiviralArenavirusBVDVApoptosis >>Apoptosis InducerBcl-2Bcl-6BRKc-Mycc-RETC/EBPCARDCaspaseAutophagy >>Atg4ATG4BATTECsAUTACsAutophagyBeclin1
FKBPLC3LRRK2Biochemical Reagent >>Cell Cycle >>AntifolateAPCAurora KinaseBUBCasein KinaseCdc25CDKChkCRISPR/Cas9Cytoskeleton >>ActinArp2/3 ComplexCYTHCytoplasmic DyneinDynaminFAKMore >>
Material Science
Aggregation-Induced Emission >>Other AIE BlocksTetraphenylethylene SeriesCOFs Linkers >>Aldehyde COFs LinkersAlkynyl COFs LinkersAmine COFs LinkersBoric COFs LinkersCyano COFs LinkersMultifunctional COFs linkersOther COFs linkersTriptycene SeriesElectronic Materials >>Battery MaterialsDye-Sensitized Solar Cell (DSSC) MaterialsElectronic MaterialLiquid Crystal (LC) MaterialsMolecular ConductorsOrganic Light-Emitting Diode (OLED) MaterialsOrganic Solar Cell (OPV) MaterialsOrganic Transistor (OFET) MaterialsPerovskite Solar Cell (PSC) MaterialsMagnetic Materials >>Magnetic Ionic LiquidsMagnetic MaterialMagnetic Metal Complexes
Organic Radicals Material Chemical Compounds >>Ligands for Functional Metal ComplexesLiquid Crystal (LC) Building BlocksPhthalocyanine Building BlocksPolymer and Macromolecule Semiconductor Building BlocksSmall Molecule Semiconductor Building BlocksSolubility Enhancing Reagents Supramolecular Host Materials MOF Ligands >>Carboxylic Acid MOF LigandsCarboxylic Acid Nitrogen-Containing Mixed MOF LigandsNitrogen-Containing MOF LigandsOther MOF LigandsNanomaterials >>Carbon NanomaterialsCeramic MembranesDendrimersGold NanoparticlesIron Oxide NanoparticlesMaterials by ApplicationMesoporous MaterialsMetals and Metal AlloysNano Minerals: NanoclaysOLED Materials >>Dopant
HostHTMOLED IntermediatesOther OLED related materialsOptical Materials >>Coumarin DyesCyanine and Squarylium DyesDCM DyesDipyrromethene DyesFluorescence MaterialsFluorescent ProbesHeat and Pressure Sensitive DyesNear-Infrared (NIR) DyesOrganic Non-Linear Optical (NLO) MaterialsOrganic Pigments >>Organic PigmentOther Materials >>Mateial OtherPolymer Science >>MonomersPolymer AdditivesPolymerization ReagentsPolymersResins
Contact Us
Home Cart 0 Sign in  
Chemistry
Organic Building Blocks
Aryls
4'-Methoxy-[1,1'-biphenyl]-3-carbaldehyde
Chemistry
Organic Building Blocks
Aryls
Ethers Aldehydes Benzene Compounds

[ CAS No. 118350-17-7 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 118350-17-7
Chemical Structure| 118350-17-7
Structure of 118350-17-7 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

For Research Only 110K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 118350-17-7 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 118350-17-7 ]

SDS Specification
Alternatived Products of [ 118350-17-7 ]

Product Details of [ 118350-17-7 ]

CAS No. :118350-17-7 MDL No. :MFCD03424627
Formula : C14H12O2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 212.24 Pubchem ID :-
Synonyms :

Safety of [ 118350-17-7 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312+P330-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P362-P403+P233-P405-P501 UN#:
Hazard Statements:H302-H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 118350-17-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 118350-17-7 ]

[ 118350-17-7 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 3132-99-8 ]
  • [ 5720-07-0 ]
  • [ 118350-17-7 ]
YieldReaction ConditionsOperation in experiment
99% With tetraamminepalladium(II) chloride; tetra(n-butyl)ammonium hydroxide In water at 45℃; for 2h; Green chemistry;
98% With potassium phosphate; tetrabutylammomium bromide In ethanol at 20℃; for 2h;
98% With sodium carbonate In ethanol; water at 120℃; for 0.0833333h; Sealed tube; Microwave irradiation; Green chemistry; Suzuki-Miyaura coupling reaction; general procedure General procedure: Into a 10 mL glass vial were placed aryl halide (0.5 mmol), phenyl- or4-methoxy phenylboronic acid (0.65 mmol), base (1 mmol), Pd-loadedcatalyst 4 (0.2 mol% Pd) and EtOH/water (1 : 1) (2 mL), and a magneticstirrer was added. The vial was sealed, placed into the microwavecavity and the reaction mixture subjected to microwave irradiation of60 W at 120 °C for 5 min. After completion, the reaction vessel wascooled to room temperature, opened and the contents were extractedwith dichloromethane three times. The organic fraction was dried withmagnesium sulfate, filtered and the solvent was removed under reducedpressure. The crude products were purified by chromatography on asilica gel column. All products were identified by 1H NMR.
98% With sodium carbonate In methanol at 150℃; for 1h; Microwave irradiation;
94% With C31H28ClN4Pd; potassium carbonate In ethanol; water at 20℃; 4.3 General procedure for the Suzuki-Miyaura reactions 4.3.2. Method B General procedure: In a reaction tube, bromobenzene (0.5mmol, 1equiv), (4-methoxyl phenyl)boronic acid (0.75mmol, 1.5equiv) and K2CO3 (1mmol, 2equiv) were dissolved in 3mL mixed solvent (EtOH:H2O, 2:1). The reaction mixture was stirred at ambient temperature and monitored by TLC. After completion, 10mL water was added to the resulting mixture, then it was extracted with ethyl acetate (3×10mL). The combined organic layer was dried over Na2SO4, filtered and concentrated. The residue was purified by silica gel column chromatography (petroleum ether as the eluent) to obtain the desired product.
87.7% With C10H9Cl2N3O3Pd; potassium hydroxide In ethanol; water at 120℃; for 0.0333333h; Microwave irradiation;
84% With sodium carbonate In ethanol; water at 80℃; for 4h;
84% With 1-isopropyl-3-methyl-2,4-diphenylimidazolium iodide; palladium diacetate; caesium carbonate In 1,4-dioxane at 80℃; for 24h; Inert atmosphere;
80% With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In tetrahydrofuran; water; toluene at 105℃; for 36h; Inert atmosphere;
66% With potassium carbonate In ethanol; toluene for 5h; Heating;
59.4% With Supported Pd(OAc)2(PPh3)2 Over Mixed Magnesium Hydroxide and Cerium Carbonate Hydroxide Composite In water at 79.84℃; for 2h; 2.3 General Procedure for Suzuki Reaction General procedure: A typical procedure for Suzuki reaction is as follows: arylhalide (0.5mmol) was weighed in 25mL round bottom flask containing boronic acids (0.6mmol), and Pd(OAc)2(PPh3)2/MgCe-HDC (100mg). The reactants and catalyst were dispersed in water (4mL), the RB was mounted on an oil bath at 353K and the mixture was stirred for 2h. The reaction was monitored by thin layer chromatography (TLC). After completion of the reaction, the catalyst was separated by filtration. Then the solution was extracted with ethyl acetate and brine solution. The organic phase was dried over anhydrous Na2SO4 and concentrated under vacuum. The crude product was purified by column chromatography on silicagel to afford pure product. The pure product was analyzed using 1H- and 13C-NMR techniques and compared with literature NMR data.
With sodium carbonate In ethanol; toluene for 5h; Heating;
With C29H25N6O2Pd(1+)*BF4(1-); potassium carbonate In N,N-dimethyl-formamide at 120℃; for 5h;

Reference： [1]Wang, Yanyan; Liu, Yuanyuan; Zhang, Wei-qiang; Sun, Huaming; Zhang, Kan; Jian, Yajun; Gu, Quan; Zhang, Guofang; Li, Jiyang; Gao, Ziwei [ChemSusChem, 2019, vol. 12, # 24, p. 5265 - 5273]
[2]Deng, Yijian; Gong, Liuzhu; Mi, Aiqiao; Liu, Hui; Jiang, Yaozhong [Synthesis, 2003, # 3, p. 337 - 339]
[3]Pan, Dan; Wu, Aiqun; Li, Pengfei; Xu, Haitang; Lei, Fuhou; Shen, Liqun [Journal of Chemical Research, 2014, vol. 38, # 12, p. 715 - 718]
[4]Supriya; Ananthnag, Guddekoppa S.; Shetti, Vijayendra S.; Nagaraja; Hegde, Gurumurthy [Applied Organometallic Chemistry, 2020, vol. 34, # 3]
[5]Fang, Yi; Wang, Shun-Yi; Ji, Shun-Jun [Tetrahedron, 2015, vol. 71, # 52, p. 9679 - 9683]
[6]Shen, Liqun; Huang, Suyu; Nie, Yuanmei; Lei, Fuhou [Molecules, 2013, vol. 18, # 2, p. 1602 - 1612]
[7]Scheuermann, Gil M.; Steurer, Peter; Muelhaupt, Rolf; Rumi, Luigi; Bannwarth, Willi [Journal of the American Chemical Society, 2009, vol. 131, # 23, p. 8262 - 8270]
[8]Location in patent: scheme or table Xu, Xiangya; Xu, Baochang; Li, Yongxin; Hong, Soon Hyeok [Organometallics, 2010, vol. 29, # 23, p. 6343 - 6349]
[9]Hunter, Christopher A.; Misuraca, Maria Cristina; Turega, Simon M. [Journal of the American Chemical Society, 2011, vol. 133, # 3, p. 582 - 594]
[10]Mitsch, Andreas; Altenkaemper, Mirko; Sattler, Isabel; Schlitzer, Martin [Archiv der Pharmazie, 2005, vol. 338, # 1, p. 9 - 17]
[11]Tomar, Ravi; Singh, Nidhi; Kumar, Neeraj; Tomar, Vartika; Chandra, Ramesh [Catalysis Letters, 2019]
[12]Wiesner; Mitsch; Altenkaemper; Ortmann; Jomaa; Schlitzer, Martin [Pharmazie, 2003, vol. 58, # 12, p. 854 - 856]
[13]Hsu, Yu-Cheng; Wang, Vincent C.-C.; Au-Yeung, Ka-Chun; Tsai, Chung-Yu; Chang, Chun-Chi; Lin, Bo-Chao; Chan, Yi-Tsu; Hsu, Chao-Ping; Yap, Glenn P. A.; Jurca, Titel; Ong, Tiow-Gan [Angewandte Chemie - International Edition, 2018, vol. 57, # 17, p. 4622 - 4626][Angew. Chem., 2018, vol. 130, # 17, p. 4712 - 4716,5]
  • 2
  • [ 1018955-96-8 ]
  • [ 29304-89-0 ]
  • [ 16064-04-3 ]
  • [ 52988-34-8 ]
  • [ 118350-17-7 ]
Reference： [1]Helvetica Chimica Acta,2008,vol. 91,p. 559 - 568
  • 3
  • [ 1018955-96-8 ]
  • [ 16064-04-3 ]
  • [ 613-37-6 ]
  • [ 52988-34-8 ]
  • [ 118350-17-7 ]
Reference： [1]Helvetica Chimica Acta,2008,vol. 91,p. 559 - 568
  • 4
  • [ 696-41-3 ]
  • [ 5720-07-0 ]
  • [ 118350-17-7 ]
YieldReaction ConditionsOperation in experiment
82% With C31H28ClN4Pd; potassium tert-butylate; In ethanol; at 20℃; General procedure: In a reaction tube, 1-iodo-3-methylbenzene (0.5mmol, 1equiv), (4-methoxyl phenyl)boronic acid (0.75mmol, 1.5equiv) and KOtBu (1mmol, 2equiv) were dissolved in 3mL anhydrous EtOH. The reaction mixture was stirred at ambient temperature and monitored by TLC. After completion, 10 mL water was added to the resulting mixture, then it was extracted with ethyl acetate (3×10mL). The combined organic layer was dried over Na2SO4, filtered and concentrated. The residue was purified by silica gel column chromatography (petroleum ether as the eluent) to obtain the desired product.
Reference： [1]Tetrahedron,2015,vol. 71,p. 9679 - 9683

Tags: 118350-17-7 synthesis path| 118350-17-7 SDS| 118350-17-7 COA| 118350-17-7 purity| 118350-17-7 application| 118350-17-7 NMR| 118350-17-7 COA| 118350-17-7 structure

Same Skeleton Products
Related Products
Categories
Chemistry
Organic Building Blocks
Aryls
Chemistry
Organic Building Blocks
Ethers
Chemistry
Organic Building Blocks
Aldehydes
Chemistry
Organic Building Blocks
Benzene Compounds
Historical Records