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Chemical Structure| 1188338-58-0 Chemical Structure| 1188338-58-0

Structure of 1188338-58-0

Chemical Structure| 1188338-58-0

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Product Details of [ 1188338-58-0 ]

CAS No. :1188338-58-0
Formula : C16H27N3O4
M.W : 325.40
SMILES Code : O=C(C1=C(CCNC(OC(C)(C)C)=O)N(C(C)(C)C)N=C1)OC

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Application In Synthesis of [ 1188338-58-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1188338-58-0 ]

[ 1188338-58-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1188338-58-0 ]
  • [ 24078-12-4 ]
  • 5-(4-bromo-2-methylbenzyl)-1-(tert-butyl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridin-4(5H)-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
20% [0540j To a solution of methyl 5 -(2-(Qert-butoxycarbonyl) amino)ethyl)- 1 -(tert-butyl)1H-pyrazole-4-carboxylate (500 mg, 1.54 mmol) in DCM (4 mL) was added TFA (4 mL). The mixture was stirred at rt for 1 h. The mixture was concentrated, the crude was dissolved in CH2C12 (10 mL) and <strong>[24078-12-4]4-bromo-2-methylbenzaldehyde</strong> (370 mg, 1.87 mmol) was added. The mixture was stirred at rt for 10 mm, then sodium triacetoxyborohydride (1.63 g, 7.7 mmol)added. The mixture was stirred at rt for 16 h, diluted with DCM (60 mL), washed with brinedried over Na2SO4, filtered and concentrated in vacuo to afford a crude residue which washeated to 100 C for 2 h. The residue was purified by prep-HPLC (CH3CN/H20 with 0.05% NH4OH as mobile phase) to give 5-(4-bromo-2-methylbenzyl)-1-(tert-butyl)-6,7-dihydro-1H- pyrazolo[4,3-c]pyridin-4(5H)-one as a white solid (116 mg, yield: 20%). ESI-MS (M+H) :376.1.
 

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