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Chemical Structure| 1188365-78-7 Chemical Structure| 1188365-78-7

Structure of 1188365-78-7

Chemical Structure| 1188365-78-7

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Product Details of [ 1188365-78-7 ]

CAS No. :1188365-78-7
Formula : C15H12ClN3OS
M.W : 317.79
SMILES Code : O=C1C2=C(C=3C=4C(C=CC3S2)=NC(Cl)=CC4)NC[C@@H](C)N1
MDL No. :N/A

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Application In Synthesis of [ 1188365-78-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1188365-78-7 ]

[ 1188365-78-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1188365-78-7 ]
  • [ 199609-62-6 ]
  • C27H28N4O3S [ No CAS ]
YieldReaction ConditionsOperation in experiment
81% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In 1,4-dioxane; water; at 100℃; for 2h; A mixture of (R)-3-chloro-10-methyl-9,10,l l,12-tetrahydro-8H- [l,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one (11, Example 51; 40 mg, 0.126 mmol), (3- (((tert-butoxycarbonyl)amino)methyl)phenyl)boronic acid (38 mg, 0.15 mmol), Pd(dppf)Cl2 (9.2 mg, 0.0126 mmol) and CS2CO3 (123 mg, 0.378 mmol) in dioxane (3 mL) and water (0.3 mL) was heated at 100 C for 2 hours. Solvent was removed and CH2CI2 and water were added and two layers were separated. The organic layer was concentrated and the residue was purified with flash chromatography on silica gel (0-30% MeOH in CH2CI2) to give the coupling product (50 mg, 81%). The product above was dissolved in CH2CI2 (3 mL) and to it was added TFA (0.3 mL) and the mixture was stirred at room temperature for 10 minutes. Solvent was removed.
 

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