Home Cart Sign in  
Chemical Structure| 1190044-80-4 Chemical Structure| 1190044-80-4

Structure of 1190044-80-4

Chemical Structure| 1190044-80-4

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 1190044-80-4 ]

CAS No. :1190044-80-4
Formula : C14H14O2
M.W : 214.26
SMILES Code : O=C(OCC)C1=CC=C(C#CC2CC2)C=C1

Safety of [ 1190044-80-4 ]

Application In Synthesis of [ 1190044-80-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1190044-80-4 ]

[ 1190044-80-4 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 1190044-80-4 ]
  • [ 908247-29-0 ]
YieldReaction ConditionsOperation in experiment
79%
Stage #1: With lithium hydroxide monohydrate; water In tetrahydrofuran; methanol at 15 - 30℃; for 3.5 h; Reflux
Stage #2: With hydrogenchloride In water at 15 - 30℃; for 0.5 h;
Reference Example 88; 4-(cyclopropylethynyl)benzoic acid; [Show Image] Ethyl 4-(cyclopropylethynyl)benzoate (2.894 g) obtained in Reference Example 87 was dissolved in a mixed solvent of methanol (10 mL), water (10 mL) and THF (15 mL), lithium hydroxide monohydrate (0.70 g) was added thereto, and the mixture was stirred at room temperature for 30 min, and heated under reflux for 3 hr. The reaction mixture was allowed to cool to room temperature, and the solvent was evaporated under reduced pressure. The residue was suspended in water, and the suspension was acidified with 1N aqueous hydrochloric acid solution (20 mL), and stirred at room temperature for 30 min. The obtained suspension was filtered, and the solid was collected by filtration was washed with water, and dried to give the title compound (2.458 g, yield 79percent) as a white solid. 1H NMR (300 MHz, DMSO-d6) δ: 0.71 - 0.82 (2 H, m) 0.86 - 0.99 (2 H, m) 1.46 - 1.66 (1 H, m) 7.46 (2 H, d, J=8.71 Hz) 7.87 (2 H, d, J=8.33 Hz) 13.08 (1 H, br. s.).
References: [1] Journal of Medicinal Chemistry, 2009, vol. 52, # 21, p. 6790 - 6802.
[2] Patent: EP2261213, 2010, A1, . Location in patent: Page/Page column 76.
 

Historical Records