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Chemical Structure| 1190862-19-1 Chemical Structure| 1190862-19-1

Structure of 1190862-19-1

Chemical Structure| 1190862-19-1

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Product Details of [ 1190862-19-1 ]

CAS No. :1190862-19-1
Formula : C11H11BrN2O2
M.W : 283.12
SMILES Code : O=C1NC2=CC(Br)=CN=C2C31CCOCC3
MDL No. :MFCD23159240

Safety of [ 1190862-19-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 1190862-19-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1190862-19-1 ]

[ 1190862-19-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 34270-90-1 ]
  • [ 1190319-62-0 ]
  • [ 1190862-19-1 ]
YieldReaction ConditionsOperation in experiment
17% To a solution of Intermediate 89 (2.00 g, 9.39 mmol) in DMSO (20 mL) wasadded CszC03 (3.05 g, 9.39 mmol) at 0C. The reaction mixture was stirred for 3025 minutes, then 1-iodo-2-(2-iodoethoxy)ethane (3.05 g, 9.39 mmol) was added. Thereaction mixture was stirred at room temperature for 5 h, then quenched with water (50mL) and extracted with EtOAc (3 x 50 mL). The organic layer was separated, dried overanhydrous NazS04 and concentrated in vacuo. The crude residue was purified by columnchromatography (20% EtOAc in hexanes) to afford the title compound (0.45 g, 17%) as a30 light brown liquid. DH (400 MHz, DMSO-d6) 1.58-1.67 (m, 2H), 1.77-1.83 (m, 2H), 3.85-3.96 (m, 2H), 3.98-4.08 (m, 2H), 7.39 (d, J 1.96 Hz, IH), 8.25 (d, J 1.96 Hz, IH), 10.78(s, IH). HPLC-MS (method 6): MH+ m/z 283.1, RT 1.54 minutes.
 

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