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Chemical Structure| 1192356-23-2 Chemical Structure| 1192356-23-2

Structure of 1192356-23-2

Chemical Structure| 1192356-23-2

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Product Details of [ 1192356-23-2 ]

CAS No. :1192356-23-2
Formula : C9H10F3NO
M.W : 205.18
SMILES Code : CC(O)(C1=NC(C(F)(F)F)=CC=C1)C

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Application In Synthesis of [ 1192356-23-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1192356-23-2 ]

[ 1192356-23-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 676-58-4 ]
  • [ 155377-05-2 ]
  • [ 1192356-23-2 ]
YieldReaction ConditionsOperation in experiment
90% Add -trifluoromethyl-pyridine^-carboxylic acid methyl ester (80.0 g, 390 mmol) to a mixture of THF (240 mL) and tert-butylmethyl ether (400 mL). Add the solution slowly to a 3 M methylmagnesium chloride in THF (390 mL, 1.17 moles) and maintain 8 0C to 16 0C. Cool the mixture to 0 0C and add a mixture of 5 M hydrochloric acid (257 mL, 1.29 moles) and water (200 mL). Separate the phases and concentrate the organic phase under reduced pressure. Add heptane (160 mL) and cool the mixture to 5 0C. Collect the precipitate by vacuum filtration and rinse the solid with heptane (20 mL) followed by pentane (30 mL). Vacuum dry the solid to afford the title compound as a tan solid (72.3 g, 352 mmol, 90 %). 1H NMR (400 MHz, DMSO d6) delta 8.04 (t, J= 7.7 Hz, IH), 7.94 (d, J= 7.9 Hz, IH), 7.69 (d, J= 7.0 Hz, IH), 5.40 (s, IH), 1.43 (s, 6H). HRMS (ESI) m/z (M+H)+ calcd for C9Hi0F3NO : 206.0787, found 206.0787.
 

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