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Chemical Structure| 1192814-44-0 Chemical Structure| 1192814-44-0

Structure of 1192814-44-0

Chemical Structure| 1192814-44-0

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Product Details of [ 1192814-44-0 ]

CAS No. :1192814-44-0
Formula : C10H12Cl2N2O
M.W : 247.12
SMILES Code : CC(C)(C)C(NC1=NC(Cl)=C(Cl)C=C1)=O
MDL No. :MFCD23115285

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Application In Synthesis of [ 1192814-44-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1192814-44-0 ]

[ 1192814-44-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1192814-44-0 ]
  • [ 1192814-45-1 ]
YieldReaction ConditionsOperation in experiment
93% With hydrogenchloride; In ethanol; water; at 85 - 90℃; for 4h; A mixture of N-(5,6-dichloropyridin-2-yl)pivalamide(790 mg, 3.20 mmol), hydrochloric acid, 37% (1.25ml.), water (1.25 ml.), and EtOH (3 mL) was heated for 4 hrsin an oil bath at 85-90 C. LCMS showed nearly completeconversion to product. The reaction was cooled to room temperatureand the reaction mixture was evaporated down to asmall volume, then transferred to a separatory funnel where it was partitioned between aqueous sodium carbonate and ethylacetate. The layers were separated, the aqueous phase waswashed again with ethyl acetate, and the combined organicphases were washed with brine, dried over MgSO4 , filtered,and evaporated to give a white solid. The material was subjectedto a Biotage colunm in 20% ethyl acetate/hexane,collecting the main component. 5,6-Dichloropyridin-2amine (0.49 g, 2.98 mmol, 93%) was obtained as a white solid.
 

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