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Chemical Structure| 1195781-24-8 Chemical Structure| 1195781-24-8

Structure of 1195781-24-8

Chemical Structure| 1195781-24-8

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Product Details of [ 1195781-24-8 ]

CAS No. :1195781-24-8
Formula : C14H12FNO3
M.W : 261.25
SMILES Code : OC1=CC(F)=C(C=C1)NC(OCC2=CC=CC=C2)=O
MDL No. :MFCD29044746

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Application In Synthesis of [ 1195781-24-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1195781-24-8 ]

[ 1195781-24-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 52092-47-4 ]
  • [ 1195781-24-8 ]
  • [ 1195781-25-9 ]
YieldReaction ConditionsOperation in experiment
77% With caesium carbonate; In dimethyl sulfoxide; at 20℃; for 6h; To a solution of benzyl (2-fluoro-4- hydroxyphenyl) carbamate (79 g, 303 mmol) in dimethyl sulfoxide (480 mL) were added cesium carbonate (123 g, 378 mmol) and 5- chloro-2-nitropyridine (40 g, 252 mmol) , and the mixture was <n="143"/>stirred at room temperature for 6 hr. Water (1000 mL) was added to the reaction mixture, and the mixture was extracted with ethyl acetate/tetrahydrofuran. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate and filtered. The solvent was evaporated under reduced pressure, and the residue was washed with hexane/ethyl acetate (=3/1) and collected by filtration to give the title compound (74 g, 77percent) .1H-NMR (DMSOd6, 300MHz) delta 5.17 (2H, s) , 7.05 - 7.12 (IH, m) , 7.27 - 7.46 (6H, m) , 7.66 - 7.78 (2H, m) , 8.34 (IH, d, J = 8.6 Hz), 8.46 (IH, d, J = 2.9 Hz), 9.57 (IH, s)
 

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