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Chemical Structure| 119755-64-5 Chemical Structure| 119755-64-5

Structure of 119755-64-5

Chemical Structure| 119755-64-5

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Product Details of [ 119755-64-5 ]

CAS No. :119755-64-5
Formula : C10H13NO2
M.W : 179.22
SMILES Code : NC1COC2=C(C=CC(OC)=C2)C1
MDL No. :MFCD09261196

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Application In Synthesis of [ 119755-64-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 119755-64-5 ]

[ 119755-64-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 766-36-9 ]
  • [ 119755-64-5 ]
  • [ 207909-99-7 ]
  • 3-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)-7-methoxychroman [ No CAS ]
YieldReaction ConditionsOperation in experiment
With 1,1'-carbonyldiimidazole; In tetrahydrofuran; Petroleum ether; Preparation of the Starting Compound 3-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)-6-sulfamoyl-7-methoxychroman STR74 8.43 g (52 mmol) of N,N'-carbonyldiimidazole were added to a solution of 8.2 g (46 mmol) of 3-amino-7-methoxychroman in 60 ml of THF. During this operation, the solution became warm. After the solution had been stirred at room temperature for one hour, it was evaporated in vacuo. The residue was melted together with 6.51 g (52 mmol) of <strong>[766-36-9]3-ethyl-4-methyl-3-pyrrolin-2-one</strong> at 160°-170° C. for 1.5 to 2 hours and the mixture was then chromatographed over silica gel using the eluding agent ethyl acetate/petroleum ether 3:1. The main fraction was evaporated and the residue was recrystallized from methanol. 3-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)-7-methoxychroman of melting point 118°-119° C. was obtained. This product was introduced by the customary procedure into chlorosulfonic acid which had been cooled to -15° C. The mixture was allowed to come to room temperature and was subsequently stirred for 1 hour. After customary work-up, the sulfochloride was converted into the sulfonamide as described in Example 1. 3-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)-6-sulfamoyl-7-methoxychroman had a melting point of 225°-227° C.
 

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