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[ CAS No. 1197943-55-7 ]

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Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 1197943-55-7
Chemical Structure| 1197943-55-7
Structure of 1197943-55-7 *Storage: {[proInfo.prStorage]}

Quality Control of [ 1197943-55-7 ]

Purity: {[proInfo.showProBatch.pb_purity]}

Related Doc. of [ 1197943-55-7 ]

SDS

Product Details of [ 1197943-55-7 ]

CAS No. :1197943-55-7MDL No. :MFCD18251689
Formula :C12H12FNO3Boiling Point :-
Linear Structure Formula :-InChI Key :N/A
M.W :237.23Pubchem ID :66920491
Synonyms :

Computed Properties of [ 1197943-55-7 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 1197943-55-7 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P280-P305 P351 P338UN#:N/A
Hazard Statements:H302-H315-H319-H332-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1197943-55-7 ]

  • Downstream synthetic route of [ 1197943-55-7 ]

[ 1197943-55-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1197943-55-7 ]
  • [ 383132-91-0 ]
YieldReaction ConditionsOperation in experiment
62% To a solution of ethyl 7-fluoro-4-methoxy-1 H-indole-2-carboxylate (1.00 g, 4.22 mmol) in ethanol was added KOH (473 mg, 8.43 mmol). The reaction was stirred at room temperature for 12 hours, cooled to 0 9C and acidified with 1 N HCI. The mixture was extracted with EtOAc and CH2CI2. The combined organic extracts were dried over Na2SO4, filtered and concentrated to afford the title compound (550 mg, 62%).
  • 2
  • [ 1197943-53-5 ]
  • [ 1197943-55-7 ]
YieldReaction ConditionsOperation in experiment
In xylenes; for 4.0h;Reflux; To xylenes (150 mL) heated at reflux was added a solution of ethyl 2-azido-3-(5- fluoro-2-methoxyphenyl)acrylate (1.50 g, 5.66 mmol) in xylenes (50 mL). The mixture was heated at reflux for 4 hours, cooled to room temperature and concentrated to -1/5 original volume. The solution was cooled to -20 2C for 2 hours and the solids were collected by vacuum filtration. The solids were washed with cold xylenes and dried under vacuum to afford [1197943-55-7]ethyl 7-fluoro-4-methoxy-1H-indole-2-carboxylate. Concentration of the mother liquor provided additional product. The solids were combined to afford the final product (0.75 g, 56%).
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