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Chemical Structure| 1199809-26-1 Chemical Structure| 1199809-26-1

Structure of 1199809-26-1

Chemical Structure| 1199809-26-1

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Product Details of [ 1199809-26-1 ]

CAS No. :1199809-26-1
Formula : C25H21ClFN5O5
M.W : 525.92
SMILES Code : C[C@@]1(F)[C@H](OC(C2=CC=CC=C2)=O)[C@@H](COC(C3=CC=CC=C3)=O)O[C@]1(N4C=NC5=C(Cl)N=C(N)N=C45)[H]

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Application In Synthesis of [ 1199809-26-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1199809-26-1 ]

[ 1199809-26-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1199809-26-1 ]
  • [ 848497-98-3 ]
  • (2R,3R,4R,5R)-5-(2-amino-6-(N-methyl-cyclobutylamino)-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol [ No CAS ]
YieldReaction ConditionsOperation in experiment
86% Step 1. Preparation of (2R,3R,4R,5R)-5-(2-amino-6-(N-methyl-cyclobutylamino)-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol (21) To a solution of compound 3 (150 mg, 0.29 mmol) in MeOH (4 mL) was added <strong>[848497-98-3]N-methylcyclobutylamine hydrochloride</strong> (105 mg, 0.90 mmol) and triethylamine (190 muL, 1.00 mmol). The reaction mixture was heated at 100 C. in a sealed tube for 15 h and cooled down to room temperature. An aqueous solution containing 30% NH4OH (1 mL) was added and the reaction mixture was heated at 100 C. in a sealed tube for 2 h, cooled down and concentrated. The residue was purified by column chromatography (gradient DCM/MeOH 100:0 to 90:10) to afford product 21 (90 mg, 0.25 mmol, 86%) as a pale yellow solid.
 

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