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Chemical Structure| 1200498-40-3 Chemical Structure| 1200498-40-3

Structure of 1200498-40-3

Chemical Structure| 1200498-40-3

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Product Details of [ 1200498-40-3 ]

CAS No. :1200498-40-3
Formula : C7H5ClFNO2
M.W : 189.57
SMILES Code : O=C(C1=NC=C(Cl)C=C1F)OC
MDL No. :MFCD14698145
InChI Key :CSCZOWZTTGYYRE-UHFFFAOYSA-N
Pubchem ID :46311239

Safety of [ 1200498-40-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362

Application In Synthesis of [ 1200498-40-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1200498-40-3 ]

[ 1200498-40-3 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 514797-96-7 ]
  • [ 1200498-40-3 ]
  • 2
  • [ 207994-08-9 ]
  • [ 18107-18-1 ]
  • [ 1200498-40-3 ]
YieldReaction ConditionsOperation in experiment
In methanol; diethyl ether; at 20℃; for 1h;Inert atmosphere; To a solution of <strong>[207994-08-9]5-chloro-3-fluoropyridine-2-carboxylic acid</strong> (6g) in MeOH (120 mL) was added (trimethylsilyl)diazomethane 2M in diethyl ether (48.6 mL). The reaction mixture was stirred at rt for 1 h. The mixture was evaporated in vacuo. The crude compound (5.65g of a brown solid) was used without purification in the next step. LC-MS (A) tR = 0.64 min; [M+H]+: 190.19.
  • 3
  • [ 67-56-1 ]
  • [ 207994-08-9 ]
  • [ 1200498-40-3 ]
YieldReaction ConditionsOperation in experiment
66.7% With thionyl chloride; at 20℃;Inert atmosphere; A solution of <strong>[207994-08-9]5-chloro-3-fluoro-pyridine-2-carboxylic acid</strong> (1000 mg, 5.70 mmol) in MeOH (20 mL) was added thionyl chloride (1355 mg, 11.4 mmol). The mixture was stirred under a nitrogen atmosphere at room temperature overnight. After concentration, the residue was diluted with DCM (20 mL) and the pH adjusted to pH = 8-9 with K2CO3 aqueous solution. The organic layer was concentrated in vacuum to afford th title compound (720 mg, 3.80 mmol, yield: 66.7 %). 1 H NMR (400 MHz, CDCh) d 8.52 (d, J = 1.1 Hz, 1 H), 7.63 (dd, J = 9.5, 1.9 Hz, 1 H), 4.02 (s, 3 H). m/z calcd for [C7H5CIFNO2] [M+l]+: 190, found: 190.
With diazomethyl-trimethyl-silane; In diethyl ether; at 20℃; for 1h; To a solution of <strong>[207994-08-9]5-chloro-3-fluoropyridine-2-carboxylic acid</strong> (6g) in MeOH (120ml) was added (trimethylsilyl)diazomethane 2M in diethyl ether (48.6ml). The reaction mixture was stirred at rt for 1 h. The mixture was evaporated in vacuo. The crude compound (5.65g of a brown solid) was used without purification in the next step. LC-MS (A) tR = 0.64min; [M+H]+: 190.19.
 

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