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Chemical Structure| 120157-60-0 Chemical Structure| 120157-60-0

Structure of 120157-60-0

Chemical Structure| 120157-60-0

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Product Details of [ 120157-60-0 ]

CAS No. :120157-60-0
Formula : C8H14O3
M.W : 158.20
SMILES Code : O=CC(CO1)OC1(CC)CC

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Application In Synthesis of [ 120157-60-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 120157-60-0 ]

[ 120157-60-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 349-43-9 ]
  • [ 120157-60-0 ]
  • [ 1033394-98-7 ]
  • [ 1033395-02-6 ]
  • [ 1033394-96-5 ]
YieldReaction ConditionsOperation in experiment
Example 2; Reaction of <strong>[349-43-9]ethyl 2-fluoropropionate</strong> (20, Ri=ethyl) with D-glyceraldehyde, 1,2- pentanonide (21, R2=ethyl)A dry, clean, 4-neck round bottom flask, equipped with a mechanic stirrer, a thermo couple, a nitrogen inlet, and an addition funnel, was charged with 20 mL of anhydrous THF and 1.8 g of diisopropylamine. The mixture was stirred and cooled to <-75°C. To the solution was slowly charged 11 mL of 1.6 M MeLi solution in ethyl ether while maintaining the batch temperature below -550C. After the addition the mixture was stirred at approximately -750C. for 30 minutes. To this mixture was then slowly added 2.1 g of <strong>[349-43-9]ethyl 2-fluoropropionate</strong> 20 while maintaining the batch temperature below -740C. The mixture was stirred at -76 0C for 30 minutes and a solution of 2 g freshly distilled D-glyceraldehyde, 1,2- pentanonide 21 in 10 mL of anhydrous THF was slowly added while maintaining batch temperature below -74 0C. After the addition the mixture was stirred for approximately 20 minutes. To it was added 20 mL of 20percent NH4Cl solution. The mixture was slowly warmed to ambient temperature and transferred to a separatory funnel. The aqueous phase was separated and extracted with 2X10 mL = 20 mL of dichloromethane. The organic phases were combined, dried over MgSO4, filtered, and concentrated to give 3 g crude aldol product as thick oil. A gas chromatogram showed the oil contained 8.2percent of 24, 36.5percent of 22, and 30.8percent of 23.
  • 2
  • [ 349-43-9 ]
  • [ 120157-60-0 ]
  • C13H23FO5 [ No CAS ]
 

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