3-Indoleacrylic acid is a potent antialgal agent that increases reactive oxygen species (ROS) production in shrimp from the East China Sea, inhibits nutrient assimilation genes, and downregulates genes for ribulose-1,5-bisphosphate carboxylase/oxygenase II and cytochrome f.

4.5 *For Research Use Only !

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Quality Control of 3-Indoleacrylic acid Purity: 98% SDS Specification

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Product Details of 3-Indoleacrylic acid

CAS No. :	1204-06-4
Formula :	C₁₁H₉NO₂
M.W :	187.19
SMILES Code :	O=C(O)C=CC1=CNC2=C1C=CC=C2
MDL No. :	MFCD00005633
InChI Key :	PLVPPLCLBIEYEA-AATRIKPKSA-N
Pubchem ID :	5375048

Safety of 3-Indoleacrylic acid

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of 3-Indoleacrylic acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 1204-06-4 ]

[ 1204-06-4 ] Synthesis Path-Downstream 1~41

1
[ 487-89-8 ]
[ 141-82-2 ]
[ 1204-06-4 ]

References: [1]Bioorganic and Medicinal Chemistry,2014,vol. 22,p. 3096 - 3104.
[2]Journal of Organic Chemistry,1958,vol. 23,p. 1171,1176.

2
[ 22948-94-3 ]
[ 141-82-2 ]
[ 1204-06-4 ]

References: [1]Journal of the Chemical Society,1957,p. 1442.

3
[ 22948-94-3 ]
[ 141-82-2 ]
[ 75629-64-0 ]
[ 1204-06-4 ]

References: [1]Journal of Organic Chemistry,1958,vol. 23,p. 1171,1176.

4
[ 1204-06-4 ]
[ 459-73-4 ]
[ 61994-18-1 ]

References: [1]Hoppe-Seyler's Zeitschrift fur Physiologische Chemie,1958,vol. 311,p. 234,237.

5
[ 622-40-2 ]
[ 1204-06-4 ]
[ 70882-53-0 ]

References: [1]Pharmaceutical Chemistry Journal,1979,vol. 13,p. 507 - 511.
Khimiko-Farmatsevticheskii Zhurnal,1979,vol. 13,p. 67 - 72.

6
[ 1204-06-4 ]
[ 120681-20-1 ]

References: [1]Chemical and Pharmaceutical Bulletin,1988,vol. 36,p. 4426 - 4434.

7
[ 830-96-6 ]
[ 1204-06-4 ]

References: [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1992,vol. 31,p. 848 - 850.

8
[ 110110-37-7 ]
[ 1204-06-4 ]

References: [1]Journal of the Chemical Society. Perkin transactions I,1988,p. 2185 - 2196.
[2]European Journal of Medicinal Chemistry,1994,vol. 29,p. 903 - 906.

9
[ 19626-93-8 ]
[ 1204-06-4 ]

References: [1]Journal of the Chemical Society. Perkin transactions I,1983,p. 1361 - 1363.

10
[ 87894-44-8 ]
[ 1204-06-4 ]

References: [1]Journal of the Chemical Society. Perkin transactions I,1983,p. 1361 - 1363.

11
[ 773-64-8 ]
[ 1204-06-4 ]
[ 156721-17-4 ]

References: [1]Tetrahedron,1994,vol. 50,p. 2391 - 2404.
[2]Tetrahedron Letters,1992,vol. 33,p. 7491 - 7494.

12
[ 6066-82-6 ]
[ 1204-06-4 ]
(E)-3-(1H-Indol-3-yl)-acrylic acid 2,5-dioxo-pyrrolidin-1-yl ester [ No CAS ]

References: [1]Journal of Medicinal Chemistry,1992,vol. 35,p. 2007 - 2014.

13
[ 101620-10-4 ]
[ 1204-06-4 ]
[ 123530-77-8 ]

References: [1]Chemical and Pharmaceutical Bulletin,1989,vol. 37,p. 684 - 687.

14
[ 1204-06-4 ]
[ 845465-13-6 ]

References: [1]Collection of Czechoslovak Chemical Communications,1998,vol. 63,p. 94 - 102.
[2]Bioorganic and Medicinal Chemistry Letters,2013,vol. 23,p. 944 - 948.

17
[ 1204-06-4 ]
[ 215790-43-5 ]
trans-(E)-N-[4-[2-(7-cyano-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-3-(3-1H-indole)-2-propenamide [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2000,vol. 43,p. 1878 - 1885.

18
[ 24424-99-5 ]
[ 1204-06-4 ]
[ 359700-09-7 ]

Yield	Reaction Conditions	Operation in experiment
36%	With dmap; triethylamine; In tetrahydrofuran; at 15℃; for 12h;	To a solution of (E)-3-(1 H-indol-3-yl)prop-2-enoic acid (21 g), Boc2O (48.97 g) and triethylamine (28.38 g) in THE (560 mL) was added 4-dimethylaminopyridine (0.685 g), and the mixturewas stirred at 15 C for 12 h. The mixture reaction was concentrated and the residue was purified by column chromatography (5i02, petroleum ether / ethyl acetate gradient) to give (E)-3-(1 -tertbutoxycarbonylindol-3-yl)prop-2-enoic acid (13 g, 36% yield) as a yellow solid.
	With dmap; triethylamine; In tetrahydrofuran; for 16h;	Step 1 (E)-3-(1H-indol-3-yl)acrylic acid (4.2 g, 22.44 mmol), (Boc)2O (10.42 ml, 44.9 mmol), and Et3N (7.82 ml, 56.1 mmol) were stirred in THF (112 ml) followed by the addition of DMAP (0.137 g, 1.122 mmol). The reaction was stirred for 16 h. The reaction was quenched with saturated sodium bicarbonate and stirred vigorously for 10 min. The mixture was diluted with EtOAc and acidified with 1 N HCl. The organic layer was collected, dried over sodium sulfate, filtered and concentrated under vacuum to give (E)-3-(1-(tert-butoxycarbonyl)-1H-indol-3-yl)acrylic acid which was carried directly to step 2.

References: [1]Tetrahedron Letters,2001,vol. 42,p. 4601 - 4603.
[2]Patent: WO2018/226732,2018,A1 .Location in patent: Page/Page column 131.
[3]Patent: US9308236,2016,B2 .Location in patent: Page/Page column 1642; 1643.

19
[ 7524-52-9 ]
[ 1204-06-4 ]
3-indole-acryltryptophan methyl ester [ No CAS ]

References: [1]Journal of Organic Chemistry,2001,vol. 66,p. 8215 - 8221.

20
[ 5680-79-5 ]
[ 1204-06-4 ]
(E)-N-[3-(1H-indol-3-yl)acryloyl]glycine methyl ester [ No CAS ]

References: [1]Journal of Pharmacy and Pharmacology,2002,vol. 54,p. 295 - 298.

21
[ 1204-06-4 ]
[ 198821-79-3 ]
3-(1H-indol-3-yl)-N-(3-methoxy-4-oxazol-5-yl-phenyl)-acrylamide [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2002,vol. 12,p. 2879 - 2882.

22
[ 1204-06-4 ]
[ 637767-83-0 ]
(E)-3-(1H-Indol-3-yl)-N-((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-piperidin-2-ylmethyl)-acrylamide [ No CAS ]

References: [1]Angewandte Chemie - International Edition,2003,vol. 42,p. 4661 - 4664.

23
[ 1204-06-4 ]
[ 252002-18-9 ]
C₂₇H₃₁N₃O [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 847 - 849.

24
[ 918663-86-2 ]
[ 1204-06-4 ]
[ 100-46-9 ]
2-(3-1H-indol-3-yl-acryloylamino)-octanedioic acid 1-benzylamide 8-hydroxyamide [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 7611 - 7622.

25
[ 3544-24-9 ]
[ 1204-06-4 ]
(E)-3-[3-(1H-indol-3-yl)acrylamido]benzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
23%	With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20℃;	EXAMPLE 2: Preparation of 3- (3-lNo.-indol-3-yl-acryloylamino) - benzamide; In 5.0 mL of dimethylformamide were dissolved 3-(1H- indol-3-yl) -acrylic acid (187 mg, 1.0 mmol) and 3-amino- benzamide (68.1 mg, 0.5 mmol), followed by the addition of benzotriazol-1-yl-oxitripyrrolidino phosphonium hexafluorophosphate (520.3 g, 1.0 mmol) and N, N- diisopropylethyl amine (0.17 ml, 1.0 mmol). The resulting solution was stirred at room temperature and mixed with ethyl acetate and an aqueous sodium salt solution. The organic layer was dried over anhydrous magnesium sulfate, concentrated, and purified using silica gel column chromatography (/i-hexane : ethyl acetate : methanol = 5:3:1) to produce the subject <n="25"/>compound (2) as a yellow solid (34.3 mg, 23%).1H-NMR (CD3OD, 300Hz): 8.17 (IH, s, Aromatic), 7.83-7.97 (3H, m, Aromatic), 7.58 (2H, m, Aromatic), 7.41 (2H, m, Aromatic), 7.19 (2H, m, Aromatic), 6.77 (IH, d, J = 15.9 Hz, Aromatic) .
	With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20℃;	1-2. Method for synthesis of low-molecular-weight compound RSC-133 (8b) [0135] Among the above-described low-molecular-weight compounds, RSC-133 (3-[3-(1H-indol-3-yl)-acrylamido]-benzamide (8b)) was synthesized in the following manner. [0136] First, trans-3-indoleacrylic acid (7a) and 3-amino-benzamide (6b) were dissolved in DMF, and benzotriazol-1-yl-N-oxy-tris(pyrrolidino)-phosphonium hexafluorophosphate (PyBOP) and N,N-diisopropylethylamine (DIPEA) were added to the solution to perform a coupling reaction. The reaction solution was stirred overnight at room temperature. The resulting material was separated and purified to obtain 3-[3-(1H-indol-3-yl)-acrylamido]-benzamido (RSC-133) as a yellow solid. The chemical characteristics and purity of RSC-133 were analyzed by 1H NMR (FIG. 6) and HPLC (FIG. 7). 1H NMR (CDCl3, 300 MHz) d = 8.90 (s, 1H), 8.21 (s, 1H), 7.86-8.03 (m, 4H), 7.76 (d, J = 8.1 Hz, 1H), 7.36-7.41 (m, 3H), 7.20 (m, 2H), 6.60 (d, J = 15.3 Hz, 2H), 3.88 (s, 3H).

References: [1]Angewandte Chemie - International Edition,2012,vol. 51,p. 12509 - 12513.
Angew. Chem.,2012,vol. 124,p. 12677 - 12681,5.
[2]Patent: WO2008/39007,2008,A1 .Location in patent: Page/Page column 23-24.
[3]Patent: EP2774918,2014,A1 .Location in patent: Paragraph 0040; 0126; 0134-0137.

26
[ 4518-10-9 ]
[ 1204-06-4 ]
(E)-3-(3-1H-indol-3-yl-acryloylamino)-benzoic acid methyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
38%	With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20℃;	EXAMPLE 4: Preparation of 3- (3-liY-indol-3-yl-acryloylamino) - benzoic acid methyl ester; In 5.0 mL of dimethylformamide were dissolved 3-(lif- indol-3-yl) -acrylic acid (150 mg, 0.8 mmol) and 3-amino benzoic acid methyl ester (218 mg, 1.44 mmol), followed by the addition of ethylenedichloride (230 mg, 1.2 mmol), N- hydroxybenzotriazole (163 mg, 1.2 mmol), and N, N- diisopropylethylamine (0.21 ml, 1.2 mmol). The resulting solution was stirred at room temperature and mixed with ethyl acetate and an aqueous sodium salt solution. The organic layer was dried over anhydrous magnesium sulfate. After the <n="27"/>filtration and concentration of the residue, the concentrate was purified using silica gel column chromatography (n-hexane : ethyl acetate : methanol = 9:3:1) to produce the subject compound (4) as a yellow solid (102 mg, 38%) . 1H-NMR (CDCl3, 300Hz): 8.90 (IH, s, NH), 8.21 (IH, s, NH), 7.86-8.03 (4H, m, aromatic), 7.76 (IH, d, J = 8.1 Hz aromatic), 7.36-7.41 (3H, m, aromatic), 7.20 (2H, m, aromatic), 6.60 (2H, d, J = 15.3 Hz, aromatic), 3.88 (3H, s, OCH3).
	With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20℃;	1-3. Synthesis of low-molecular-weight compound ID-52 (8a) Among the above-described low-molecular-weight compounds, ID-52 (3-(3-1H-indol-3-yl-acryloylamino)-benzoic acid methyl ester (8a)) was prepared in the following manner. Trans-3-indoleacrylic acid (7a, 150 mg, 0.8 mmol) and 3-amino-benzoic acid methyl ester (6a, 218 mg, 1.44 mmol) were dissolved in DMF, and 1-[3-(dimethyamino)propyl]-3-ethylcarbodiimide hydrochloride (EDC, 230 mg, 1.2 mmol), hydroxy-7-azabenotriazole (HOAT, 163 mg, 1.2 mmol) and N,N-diisopropylethylamine (DIPEA, 0.21 mL, 1.2 mmol) were added to the solution to cause a coupling reaction. The reaction solution was stirred overnight at room temperature. Then, the resulting material was separated and purified to obtain 3-(3-1H-indol-3-yl-acryloylamino)-benzoic acid methyl ester (ID-52) as a yellow solid. 1H NMR (CDCl3, 300 MHz) d = 8.90 (s, 1H), 8.21 (s, 1H), 7.86-8.03 (m, 4H), 7.76 (d, J = 8.1 Hz, 1H), 7.36-7.41 (m, 3H), 7.20 (m, 2H), 6.60 (d, J = 15.3 Hz, 2H), 3.88 (s, 3H).

References: [1]Organic and Biomolecular Chemistry,2013,vol. 11,p. 849 - 858.
[2]Angewandte Chemie - International Edition,2012,vol. 51,p. 12509 - 12513.
Angew. Chem.,2012,vol. 124,p. 12677 - 12681,5.
[3]Patent: WO2008/39007,2008,A1 .Location in patent: Page/Page column 25-26.
[4]Patent: EP2774918,2014,A1 .Location in patent: Paragraph 0126; 0137-0138.

27
[ 952285-87-9 ]
[ 1204-06-4 ]
C₂₉H₃₂FN₅O₄ [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2007,vol. 17,p. 5227 - 5232.

28
[ 1204-06-4 ]
[ 61994-17-0 ]

References: [1]Journal of Pharmacy and Pharmacology,2002,vol. 54,p. 295 - 298.
[2]Hoppe-Seyler's Zeitschrift fur Physiologische Chemie,1958,vol. 311,p. 234,237.

29
[ 1204-06-4 ]
3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-N-{2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-vinyl}-acrylamide [ No CAS ]

References: [1]Journal of Organic Chemistry,2001,vol. 66,p. 8215 - 8221.

30
[ 1204-06-4 ]
3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-N-{2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-vinyl}-acrylamide [ No CAS ]

References: [1]Journal of Organic Chemistry,2001,vol. 66,p. 8215 - 8221.

31
[ 1204-06-4 ]
3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-2-{3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-acryloylamino}-propionic acid methyl ester [ No CAS ]

References: [1]Journal of Organic Chemistry,2001,vol. 66,p. 8215 - 8221.

32
[ 1204-06-4 ]
[ 1026447-98-2 ]

References: [1]Journal of Organic Chemistry,2001,vol. 66,p. 8215 - 8221.

33
[ 1204-06-4 ]
3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-2-{3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-acryloylamino}-propionic acid [ No CAS ]

References: [1]Journal of Organic Chemistry,2001,vol. 66,p. 8215 - 8221.

34
[ 1204-06-4 ]
(2S,3S)-2-amino-3-(1-(tert-butoxycarbonyl)-1H-indol-3-yl)butanoic acid [ No CAS ]

References: [1]Tetrahedron Letters,2001,vol. 42,p. 4601 - 4603.
[2]Patent: US9308236,2016,B2 .

35
[ 1204-06-4 ]
(2S,3S)-2-azido-3-(1-(tert-butoxycarbonyl)-1H-indol-3-yl)butanoic acid [ No CAS ]

References: [1]Tetrahedron Letters,2001,vol. 42,p. 4601 - 4603.
[2]Patent: US9308236,2016,B2 .

36
[ 1204-06-4 ]
[ 876307-10-7 ]

References: [1]Tetrahedron Letters,2001,vol. 42,p. 4601 - 4603.
[2]Patent: US9308236,2016,B2 .

37
[ 1204-06-4 ]
3-[(R)-1-Methyl-3-oxo-3-((R)-2-oxo-4-phenyl-oxazolidin-3-yl)-propyl]-indole-1-carboxylic acid tert-butyl ester [ No CAS ]

References: [1]Tetrahedron Letters,2001,vol. 42,p. 4601 - 4603.

38
[ 1204-06-4 ]
tert-butyl 3-((2S,3R)-3-bromo-4-oxo-4-((R)-2-oxo-4-phenyloxazolidin-3-yl)butan-2-yl)-1H-indole-1-carboxylate [ No CAS ]

References: [1]Tetrahedron Letters,2001,vol. 42,p. 4601 - 4603.
[2]Patent: US9308236,2016,B2 .

39
[ 1204-06-4 ]
tert-butyl 3-((2S,3S)-3-azido-4-oxo-4-((R)-2-oxo-4-phenyloxazolidin-3-yl)butan-2-yl)-1H-indole-1-carboxylate [ No CAS ]

References: [1]Tetrahedron Letters,2001,vol. 42,p. 4601 - 4603.
[2]Patent: US9308236,2016,B2 .

40
[ 1204-06-4 ]
(2S,3S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-(tert-butoxycarbonyl)-1H-indol-3-yl)butanoic acid [ No CAS ]

References: [1]Tetrahedron Letters,2001,vol. 42,p. 4601 - 4603.
[2]Patent: US9308236,2016,B2 .

41
[ 1204-06-4 ]
[ 204907-01-7 ]

References: [1]Collection of Czechoslovak Chemical Communications,1998,vol. 63,p. 94 - 102.

Historical Records

Technical Information

• Arndt-Eistert Homologation • Hunsdiecker-Borodin Reaction • Passerini Reaction • Preparation of Amines • Preparation of Carboxylic Acids • Reactions of Amines • Reactions of Carboxylic Acids • Schmidt Reaction • Specialized Acylation Reagents-Ketenes • Ugi Reaction

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P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 1204-06-4

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CAS No.: 1204-06-4

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